Cargando…
A Protein-Based, Long-Acting HIV-1 Fusion Inhibitor with an Improved Pharmacokinetic Profile
Recently, a series of highly effective peptide- or protein-based HIV fusion inhibitors have been identified. However, due to their short half-life, their clinical application is limited. Therefore, the development of long-acting HIV fusion inhibitors is urgently needed. Here, we designed and constru...
Autores principales: | Xu, Wei, Cong, Zhe, Duan, Qianyu, Wang, Qian, Su, Shan, Wang, Rui, Lu, Lu, Xue, Jing, Jiang, Shibo |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025429/ https://www.ncbi.nlm.nih.gov/pubmed/35455421 http://dx.doi.org/10.3390/ph15040424 |
Ejemplares similares
-
A Modified Fibronectin Type III Domain-Conjugated, Long-Acting Pan-Coronavirus Fusion Inhibitor with Extended Half-Life
por: Duan, Qianyu, et al.
Publicado: (2022) -
Adding an Artificial Tail—Anchor to a Peptide-Based HIV-1 Fusion Inhibitor for Improvement of Its Potency and Resistance Profile
por: Su, Shan, et al.
Publicado: (2017) -
An HR2-Mimicking
Sulfonyl-γ-AApeptide Is a Potent
Pan-coronavirus Fusion Inhibitor with Strong Blood–Brain Barrier
Permeability, Long Half-Life, and Promising Oral Bioavailability
por: Xue, Songyi, et al.
Publicado: (2023) -
Long-Acting HIV-1 Fusion Inhibitory Peptides and their Mechanisms of Action
por: Wang, Chen, et al.
Publicado: (2019) -
A Peptide-Based HIV-1 Fusion Inhibitor with Two Tail-Anchors and Palmitic Acid Exhibits Substantially Improved In Vitro and Ex Vivo Anti-HIV-1 Activity and Prolonged In Vivo Half-Life
por: Su, Shan, et al.
Publicado: (2019)