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Exploring Thermal Sensitivities and Adaptations of Oxidative Phosphorylation Pathways

Temperature shifts are a major challenge to animals; they drive adaptations in organisms and species, and affect all physiological functions in ectothermic organisms. Understanding the origin and mechanisms of these adaptations is critical for determining whether ectothermic organisms will be able t...

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Autores principales: Lemieux, Hélène, Blier, Pierre U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025460/
https://www.ncbi.nlm.nih.gov/pubmed/35448547
http://dx.doi.org/10.3390/metabo12040360
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author Lemieux, Hélène
Blier, Pierre U.
author_facet Lemieux, Hélène
Blier, Pierre U.
author_sort Lemieux, Hélène
collection PubMed
description Temperature shifts are a major challenge to animals; they drive adaptations in organisms and species, and affect all physiological functions in ectothermic organisms. Understanding the origin and mechanisms of these adaptations is critical for determining whether ectothermic organisms will be able to survive when faced with global climate change. Mitochondrial oxidative phosphorylation is thought to be an important metabolic player in this regard, since the capacity of the mitochondria to produce energy greatly varies according to temperature. However, organism survival and fitness depend not only on how much energy is produced, but, more precisely, on how oxidative phosphorylation is affected and which step of the process dictates thermal sensitivity. These questions need to be addressed from a new perspective involving a complex view of mitochondrial oxidative phosphorylation and its related pathways. In this review, we examine the effect of temperature on the commonly measured pathways, but mainly focus on the potential impact of lesser-studied pathways and related steps, including the electron-transferring flavoprotein pathway, glycerophosphate dehydrogenase, dihydroorotate dehydrogenase, choline dehydrogenase, proline dehydrogenase, and sulfide:quinone oxidoreductase. Our objective is to reveal new avenues of research that can address the impact of temperature on oxidative phosphorylation in all its complexity to better portray the limitations and the potential adaptations of aerobic metabolism.
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spelling pubmed-90254602022-04-23 Exploring Thermal Sensitivities and Adaptations of Oxidative Phosphorylation Pathways Lemieux, Hélène Blier, Pierre U. Metabolites Review Temperature shifts are a major challenge to animals; they drive adaptations in organisms and species, and affect all physiological functions in ectothermic organisms. Understanding the origin and mechanisms of these adaptations is critical for determining whether ectothermic organisms will be able to survive when faced with global climate change. Mitochondrial oxidative phosphorylation is thought to be an important metabolic player in this regard, since the capacity of the mitochondria to produce energy greatly varies according to temperature. However, organism survival and fitness depend not only on how much energy is produced, but, more precisely, on how oxidative phosphorylation is affected and which step of the process dictates thermal sensitivity. These questions need to be addressed from a new perspective involving a complex view of mitochondrial oxidative phosphorylation and its related pathways. In this review, we examine the effect of temperature on the commonly measured pathways, but mainly focus on the potential impact of lesser-studied pathways and related steps, including the electron-transferring flavoprotein pathway, glycerophosphate dehydrogenase, dihydroorotate dehydrogenase, choline dehydrogenase, proline dehydrogenase, and sulfide:quinone oxidoreductase. Our objective is to reveal new avenues of research that can address the impact of temperature on oxidative phosphorylation in all its complexity to better portray the limitations and the potential adaptations of aerobic metabolism. MDPI 2022-04-17 /pmc/articles/PMC9025460/ /pubmed/35448547 http://dx.doi.org/10.3390/metabo12040360 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lemieux, Hélène
Blier, Pierre U.
Exploring Thermal Sensitivities and Adaptations of Oxidative Phosphorylation Pathways
title Exploring Thermal Sensitivities and Adaptations of Oxidative Phosphorylation Pathways
title_full Exploring Thermal Sensitivities and Adaptations of Oxidative Phosphorylation Pathways
title_fullStr Exploring Thermal Sensitivities and Adaptations of Oxidative Phosphorylation Pathways
title_full_unstemmed Exploring Thermal Sensitivities and Adaptations of Oxidative Phosphorylation Pathways
title_short Exploring Thermal Sensitivities and Adaptations of Oxidative Phosphorylation Pathways
title_sort exploring thermal sensitivities and adaptations of oxidative phosphorylation pathways
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025460/
https://www.ncbi.nlm.nih.gov/pubmed/35448547
http://dx.doi.org/10.3390/metabo12040360
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