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Alteration of Neural Pathways and Its Implications in Alzheimer’s Disease

Alzheimer’s disease (AD) is a neurodegenerative disease accompanied by cognitive and behavioral symptoms. These AD-related manifestations result from the alteration of neural circuitry by aggregated forms of amyloid-β (Aβ) and hyperphosphorylated tau, which are neurotoxic. From a neuroscience perspe...

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Autores principales: Kim, Sujin, Nam, Yunkwon, Kim, Hyeon soo, Jung, Haram, Jeon, Seong Gak, Hong, Sang Bum, Moon, Minho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025507/
https://www.ncbi.nlm.nih.gov/pubmed/35453595
http://dx.doi.org/10.3390/biomedicines10040845
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author Kim, Sujin
Nam, Yunkwon
Kim, Hyeon soo
Jung, Haram
Jeon, Seong Gak
Hong, Sang Bum
Moon, Minho
author_facet Kim, Sujin
Nam, Yunkwon
Kim, Hyeon soo
Jung, Haram
Jeon, Seong Gak
Hong, Sang Bum
Moon, Minho
author_sort Kim, Sujin
collection PubMed
description Alzheimer’s disease (AD) is a neurodegenerative disease accompanied by cognitive and behavioral symptoms. These AD-related manifestations result from the alteration of neural circuitry by aggregated forms of amyloid-β (Aβ) and hyperphosphorylated tau, which are neurotoxic. From a neuroscience perspective, identifying neural circuits that integrate various inputs and outputs to determine behaviors can provide insight into the principles of behavior. Therefore, it is crucial to understand the alterations in the neural circuits associated with AD-related behavioral and psychological symptoms. Interestingly, it is well known that the alteration of neural circuitry is prominent in the brains of patients with AD. Here, we selected specific regions in the AD brain that are associated with AD-related behavioral and psychological symptoms, and reviewed studies of healthy and altered efferent pathways to the target regions. Moreover, we propose that specific neural circuits that are altered in the AD brain can be potential targets for AD treatment. Furthermore, we provide therapeutic implications for targeting neuronal circuits through various therapeutic approaches and the appropriate timing of treatment for AD.
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spelling pubmed-90255072022-04-23 Alteration of Neural Pathways and Its Implications in Alzheimer’s Disease Kim, Sujin Nam, Yunkwon Kim, Hyeon soo Jung, Haram Jeon, Seong Gak Hong, Sang Bum Moon, Minho Biomedicines Review Alzheimer’s disease (AD) is a neurodegenerative disease accompanied by cognitive and behavioral symptoms. These AD-related manifestations result from the alteration of neural circuitry by aggregated forms of amyloid-β (Aβ) and hyperphosphorylated tau, which are neurotoxic. From a neuroscience perspective, identifying neural circuits that integrate various inputs and outputs to determine behaviors can provide insight into the principles of behavior. Therefore, it is crucial to understand the alterations in the neural circuits associated with AD-related behavioral and psychological symptoms. Interestingly, it is well known that the alteration of neural circuitry is prominent in the brains of patients with AD. Here, we selected specific regions in the AD brain that are associated with AD-related behavioral and psychological symptoms, and reviewed studies of healthy and altered efferent pathways to the target regions. Moreover, we propose that specific neural circuits that are altered in the AD brain can be potential targets for AD treatment. Furthermore, we provide therapeutic implications for targeting neuronal circuits through various therapeutic approaches and the appropriate timing of treatment for AD. MDPI 2022-04-04 /pmc/articles/PMC9025507/ /pubmed/35453595 http://dx.doi.org/10.3390/biomedicines10040845 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kim, Sujin
Nam, Yunkwon
Kim, Hyeon soo
Jung, Haram
Jeon, Seong Gak
Hong, Sang Bum
Moon, Minho
Alteration of Neural Pathways and Its Implications in Alzheimer’s Disease
title Alteration of Neural Pathways and Its Implications in Alzheimer’s Disease
title_full Alteration of Neural Pathways and Its Implications in Alzheimer’s Disease
title_fullStr Alteration of Neural Pathways and Its Implications in Alzheimer’s Disease
title_full_unstemmed Alteration of Neural Pathways and Its Implications in Alzheimer’s Disease
title_short Alteration of Neural Pathways and Its Implications in Alzheimer’s Disease
title_sort alteration of neural pathways and its implications in alzheimer’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025507/
https://www.ncbi.nlm.nih.gov/pubmed/35453595
http://dx.doi.org/10.3390/biomedicines10040845
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