Theoretical and Experimental Studies of Phosphonium Ionic Liquids as Potential Antibacterials of MDR Acinetobacter baumannii

A previously developed model to predict antibacterial activity of ionic liquids against a resistant A. baumannii strain was used to assess activity of phosphonium ionic liquids. Their antioxidant potential was additionally evaluated with newly developed models, which were based on public data. The a...

Descripción completa

Detalles Bibliográficos
Autores principales: Metelytsia, Larysa O., Hodyna, Diana M., Semenyuta, Ivan V., Kovalishyn, Vasyl V., Rogalsky, Sergiy P., Derevianko, Kateryna Yu, Brovarets, Volodymyr S., Tetko, Igor V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025513/
https://www.ncbi.nlm.nih.gov/pubmed/35453241
http://dx.doi.org/10.3390/antibiotics11040491
Descripción
Sumario:A previously developed model to predict antibacterial activity of ionic liquids against a resistant A. baumannii strain was used to assess activity of phosphonium ionic liquids. Their antioxidant potential was additionally evaluated with newly developed models, which were based on public data. The accuracy of the models was rigorously evaluated using cross-validation as well as test set prediction. Six alkyl triphenylphosphonium and alkyl tributylphosphonium bromides with the C(8), C(10), and C(12) alkyl chain length were synthesized and tested in vitro. Experimental studies confirmed their activity against A. baumannii as well as showed pronounced antioxidant properties. These results suggest that phosphonium ionic liquids could be promising lead structures against A. baumannii.

Ejemplares similares