Cilia Stimulatory and Antibacterial Activities of T2R Bitter Taste Receptor Agonist Diphenhydramine: Insights into Repurposing Bitter Drugs for Nasal Infections

T2R bitter taste receptors in airway motile cilia increase ciliary beat frequency (CBF) and nitric oxide (NO) production. Polymorphisms in some T2Rs are linked to disease outcomes in chronic rhinosinusitis (CRS) and cystic fibrosis (CF). We examined the expression of cilia T2Rs during the differenti...

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Detalles Bibliográficos
Autores principales: Kuek, Li Eon, McMahon, Derek B., Ma, Ray Z., Miller, Zoey A., Jolivert, Jennifer F., Adappa, Nithin D., Palmer, James N., Lee, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025516/
https://www.ncbi.nlm.nih.gov/pubmed/35455449
http://dx.doi.org/10.3390/ph15040452

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