Cargando…

Metabolic Phenotypes—The Game Changer in Quality of Life of Obese Patients?

Background: The present study aimed to investigate the association of obesity phenotypes and quality of life (QoL) scales and their relationship with fat mass (FM) parameters. Methods: This study categorized 104 subjects into 4 obesity phenotypes based on BMI and metabolic syndrome status: metabolic...

Descripción completa

Detalles Bibliográficos
Autores principales: Mitu, Ivona, Preda, Cristina, Dimitriu, Cristina Daniela, Mitu, Ovidiu, Costache, Irina Iuliana, Ciocoiu, Manuela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025564/
https://www.ncbi.nlm.nih.gov/pubmed/35455798
http://dx.doi.org/10.3390/healthcare10040617
_version_ 1784690904237342720
author Mitu, Ivona
Preda, Cristina
Dimitriu, Cristina Daniela
Mitu, Ovidiu
Costache, Irina Iuliana
Ciocoiu, Manuela
author_facet Mitu, Ivona
Preda, Cristina
Dimitriu, Cristina Daniela
Mitu, Ovidiu
Costache, Irina Iuliana
Ciocoiu, Manuela
author_sort Mitu, Ivona
collection PubMed
description Background: The present study aimed to investigate the association of obesity phenotypes and quality of life (QoL) scales and their relationship with fat mass (FM) parameters. Methods: This study categorized 104 subjects into 4 obesity phenotypes based on BMI and metabolic syndrome status: metabolically healthy obese (MHO), metabolically unhealthy obese (MUO), metabolically healthy non-obese (MHNO), and metabolically unhealthy non-obese (MUNO). Body composition was measured by dual-energy X-ray absorptiometry (DEXA) and metabolic profile was characterized by blood samples. All subjects completed the SF-36 item Short Form Health Survey Questionnaire. Results: Comparing the four obesity phenotypes, significant results were reported for Bodily Pain between MHNO/MUNO (p = 0.034), for Vitality between MHO/MUO (p = 0.024), and for Mental Component Score between MHO/MUO (p = 0.026) and MUO/MUNO (p = 0.003). A more thorough inside-groups analysis yielded a positive and moderate to high correlation between FM parameters and QoL scales in MHO and MHNO, while a negative and weak to moderate correlation was observed in MUO and MUNO. Conclusion: This study reported an inverse U-shaped relationship between FM and QoL in obesity phenotypes, suggesting that metabolic status is a key factor involved in modulating QoL and therefore challenging the idea of obesity as a main driver of low QoL. We recommend the inclusion of FM percentage in the definition of obesity phenotypes in future research, to better evaluate QoL of obesity phenotypes.
format Online
Article
Text
id pubmed-9025564
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-90255642022-04-23 Metabolic Phenotypes—The Game Changer in Quality of Life of Obese Patients? Mitu, Ivona Preda, Cristina Dimitriu, Cristina Daniela Mitu, Ovidiu Costache, Irina Iuliana Ciocoiu, Manuela Healthcare (Basel) Article Background: The present study aimed to investigate the association of obesity phenotypes and quality of life (QoL) scales and their relationship with fat mass (FM) parameters. Methods: This study categorized 104 subjects into 4 obesity phenotypes based on BMI and metabolic syndrome status: metabolically healthy obese (MHO), metabolically unhealthy obese (MUO), metabolically healthy non-obese (MHNO), and metabolically unhealthy non-obese (MUNO). Body composition was measured by dual-energy X-ray absorptiometry (DEXA) and metabolic profile was characterized by blood samples. All subjects completed the SF-36 item Short Form Health Survey Questionnaire. Results: Comparing the four obesity phenotypes, significant results were reported for Bodily Pain between MHNO/MUNO (p = 0.034), for Vitality between MHO/MUO (p = 0.024), and for Mental Component Score between MHO/MUO (p = 0.026) and MUO/MUNO (p = 0.003). A more thorough inside-groups analysis yielded a positive and moderate to high correlation between FM parameters and QoL scales in MHO and MHNO, while a negative and weak to moderate correlation was observed in MUO and MUNO. Conclusion: This study reported an inverse U-shaped relationship between FM and QoL in obesity phenotypes, suggesting that metabolic status is a key factor involved in modulating QoL and therefore challenging the idea of obesity as a main driver of low QoL. We recommend the inclusion of FM percentage in the definition of obesity phenotypes in future research, to better evaluate QoL of obesity phenotypes. MDPI 2022-03-25 /pmc/articles/PMC9025564/ /pubmed/35455798 http://dx.doi.org/10.3390/healthcare10040617 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mitu, Ivona
Preda, Cristina
Dimitriu, Cristina Daniela
Mitu, Ovidiu
Costache, Irina Iuliana
Ciocoiu, Manuela
Metabolic Phenotypes—The Game Changer in Quality of Life of Obese Patients?
title Metabolic Phenotypes—The Game Changer in Quality of Life of Obese Patients?
title_full Metabolic Phenotypes—The Game Changer in Quality of Life of Obese Patients?
title_fullStr Metabolic Phenotypes—The Game Changer in Quality of Life of Obese Patients?
title_full_unstemmed Metabolic Phenotypes—The Game Changer in Quality of Life of Obese Patients?
title_short Metabolic Phenotypes—The Game Changer in Quality of Life of Obese Patients?
title_sort metabolic phenotypes—the game changer in quality of life of obese patients?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025564/
https://www.ncbi.nlm.nih.gov/pubmed/35455798
http://dx.doi.org/10.3390/healthcare10040617
work_keys_str_mv AT mituivona metabolicphenotypesthegamechangerinqualityoflifeofobesepatients
AT predacristina metabolicphenotypesthegamechangerinqualityoflifeofobesepatients
AT dimitriucristinadaniela metabolicphenotypesthegamechangerinqualityoflifeofobesepatients
AT mituovidiu metabolicphenotypesthegamechangerinqualityoflifeofobesepatients
AT costacheirinaiuliana metabolicphenotypesthegamechangerinqualityoflifeofobesepatients
AT ciocoiumanuela metabolicphenotypesthegamechangerinqualityoflifeofobesepatients