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Metabolic Phenotypes—The Game Changer in Quality of Life of Obese Patients?
Background: The present study aimed to investigate the association of obesity phenotypes and quality of life (QoL) scales and their relationship with fat mass (FM) parameters. Methods: This study categorized 104 subjects into 4 obesity phenotypes based on BMI and metabolic syndrome status: metabolic...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025564/ https://www.ncbi.nlm.nih.gov/pubmed/35455798 http://dx.doi.org/10.3390/healthcare10040617 |
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author | Mitu, Ivona Preda, Cristina Dimitriu, Cristina Daniela Mitu, Ovidiu Costache, Irina Iuliana Ciocoiu, Manuela |
author_facet | Mitu, Ivona Preda, Cristina Dimitriu, Cristina Daniela Mitu, Ovidiu Costache, Irina Iuliana Ciocoiu, Manuela |
author_sort | Mitu, Ivona |
collection | PubMed |
description | Background: The present study aimed to investigate the association of obesity phenotypes and quality of life (QoL) scales and their relationship with fat mass (FM) parameters. Methods: This study categorized 104 subjects into 4 obesity phenotypes based on BMI and metabolic syndrome status: metabolically healthy obese (MHO), metabolically unhealthy obese (MUO), metabolically healthy non-obese (MHNO), and metabolically unhealthy non-obese (MUNO). Body composition was measured by dual-energy X-ray absorptiometry (DEXA) and metabolic profile was characterized by blood samples. All subjects completed the SF-36 item Short Form Health Survey Questionnaire. Results: Comparing the four obesity phenotypes, significant results were reported for Bodily Pain between MHNO/MUNO (p = 0.034), for Vitality between MHO/MUO (p = 0.024), and for Mental Component Score between MHO/MUO (p = 0.026) and MUO/MUNO (p = 0.003). A more thorough inside-groups analysis yielded a positive and moderate to high correlation between FM parameters and QoL scales in MHO and MHNO, while a negative and weak to moderate correlation was observed in MUO and MUNO. Conclusion: This study reported an inverse U-shaped relationship between FM and QoL in obesity phenotypes, suggesting that metabolic status is a key factor involved in modulating QoL and therefore challenging the idea of obesity as a main driver of low QoL. We recommend the inclusion of FM percentage in the definition of obesity phenotypes in future research, to better evaluate QoL of obesity phenotypes. |
format | Online Article Text |
id | pubmed-9025564 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90255642022-04-23 Metabolic Phenotypes—The Game Changer in Quality of Life of Obese Patients? Mitu, Ivona Preda, Cristina Dimitriu, Cristina Daniela Mitu, Ovidiu Costache, Irina Iuliana Ciocoiu, Manuela Healthcare (Basel) Article Background: The present study aimed to investigate the association of obesity phenotypes and quality of life (QoL) scales and their relationship with fat mass (FM) parameters. Methods: This study categorized 104 subjects into 4 obesity phenotypes based on BMI and metabolic syndrome status: metabolically healthy obese (MHO), metabolically unhealthy obese (MUO), metabolically healthy non-obese (MHNO), and metabolically unhealthy non-obese (MUNO). Body composition was measured by dual-energy X-ray absorptiometry (DEXA) and metabolic profile was characterized by blood samples. All subjects completed the SF-36 item Short Form Health Survey Questionnaire. Results: Comparing the four obesity phenotypes, significant results were reported for Bodily Pain between MHNO/MUNO (p = 0.034), for Vitality between MHO/MUO (p = 0.024), and for Mental Component Score between MHO/MUO (p = 0.026) and MUO/MUNO (p = 0.003). A more thorough inside-groups analysis yielded a positive and moderate to high correlation between FM parameters and QoL scales in MHO and MHNO, while a negative and weak to moderate correlation was observed in MUO and MUNO. Conclusion: This study reported an inverse U-shaped relationship between FM and QoL in obesity phenotypes, suggesting that metabolic status is a key factor involved in modulating QoL and therefore challenging the idea of obesity as a main driver of low QoL. We recommend the inclusion of FM percentage in the definition of obesity phenotypes in future research, to better evaluate QoL of obesity phenotypes. MDPI 2022-03-25 /pmc/articles/PMC9025564/ /pubmed/35455798 http://dx.doi.org/10.3390/healthcare10040617 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Mitu, Ivona Preda, Cristina Dimitriu, Cristina Daniela Mitu, Ovidiu Costache, Irina Iuliana Ciocoiu, Manuela Metabolic Phenotypes—The Game Changer in Quality of Life of Obese Patients? |
title | Metabolic Phenotypes—The Game Changer in Quality of Life of Obese Patients? |
title_full | Metabolic Phenotypes—The Game Changer in Quality of Life of Obese Patients? |
title_fullStr | Metabolic Phenotypes—The Game Changer in Quality of Life of Obese Patients? |
title_full_unstemmed | Metabolic Phenotypes—The Game Changer in Quality of Life of Obese Patients? |
title_short | Metabolic Phenotypes—The Game Changer in Quality of Life of Obese Patients? |
title_sort | metabolic phenotypes—the game changer in quality of life of obese patients? |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025564/ https://www.ncbi.nlm.nih.gov/pubmed/35455798 http://dx.doi.org/10.3390/healthcare10040617 |
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