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HHT-Related Epistaxis and Pregnancy—A Retrospective Survey and Recommendations for Management from an Otorhinolaryngology Perspective

Appropriate management of hereditary hemorrhagic telangiectasia (HHT) is of particular importance in females, as HHT-mediated modifications of the vascular bed and circulation are known to increase the risk of complications during pregnancy and delivery. This study was undertaken to evaluate female...

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Autores principales: Andorfer, Kornelia E. C., Seebauer, Caroline T., Dienemann, Carolin, Marcrum, Steven C., Fischer, René, Bohr, Christopher, Kühnel, Thomas S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025602/
https://www.ncbi.nlm.nih.gov/pubmed/35456271
http://dx.doi.org/10.3390/jcm11082178
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author Andorfer, Kornelia E. C.
Seebauer, Caroline T.
Dienemann, Carolin
Marcrum, Steven C.
Fischer, René
Bohr, Christopher
Kühnel, Thomas S.
author_facet Andorfer, Kornelia E. C.
Seebauer, Caroline T.
Dienemann, Carolin
Marcrum, Steven C.
Fischer, René
Bohr, Christopher
Kühnel, Thomas S.
author_sort Andorfer, Kornelia E. C.
collection PubMed
description Appropriate management of hereditary hemorrhagic telangiectasia (HHT) is of particular importance in females, as HHT-mediated modifications of the vascular bed and circulation are known to increase the risk of complications during pregnancy and delivery. This study was undertaken to evaluate female HHT patients’ awareness of and experience with HHT during pregnancy and delivery, with a focus on epistaxis. In this retrospective study, 46 females (median age: 60 years) with confirmed HHT completed a 17-item questionnaire assessing knowledge of HHT and its pregnancy-associated complications, the severity of epistaxis during past pregnancies and deliveries, and the desire for better education and counselling regarding HHT and pregnancy. Results revealed that 85% of participants were unaware of their disease status prior to the completion of all pregnancies. Further, 91% reported no knowledge of increased pregnancy-related risk due to HHT. In regard to epistaxis, 61% of respondents reported experiencing nosebleeds during pregnancy. Finally, approximately a third of respondents suggested that receiving counseling on the risks of HHT in pregnancy could have been helpful. Findings suggest that awareness of HHT and its potential for increasing pregnancy-related risk is poor. Best practices in HHT management should be followed to minimize negative effects of the disorder.
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spelling pubmed-90256022022-04-23 HHT-Related Epistaxis and Pregnancy—A Retrospective Survey and Recommendations for Management from an Otorhinolaryngology Perspective Andorfer, Kornelia E. C. Seebauer, Caroline T. Dienemann, Carolin Marcrum, Steven C. Fischer, René Bohr, Christopher Kühnel, Thomas S. J Clin Med Article Appropriate management of hereditary hemorrhagic telangiectasia (HHT) is of particular importance in females, as HHT-mediated modifications of the vascular bed and circulation are known to increase the risk of complications during pregnancy and delivery. This study was undertaken to evaluate female HHT patients’ awareness of and experience with HHT during pregnancy and delivery, with a focus on epistaxis. In this retrospective study, 46 females (median age: 60 years) with confirmed HHT completed a 17-item questionnaire assessing knowledge of HHT and its pregnancy-associated complications, the severity of epistaxis during past pregnancies and deliveries, and the desire for better education and counselling regarding HHT and pregnancy. Results revealed that 85% of participants were unaware of their disease status prior to the completion of all pregnancies. Further, 91% reported no knowledge of increased pregnancy-related risk due to HHT. In regard to epistaxis, 61% of respondents reported experiencing nosebleeds during pregnancy. Finally, approximately a third of respondents suggested that receiving counseling on the risks of HHT in pregnancy could have been helpful. Findings suggest that awareness of HHT and its potential for increasing pregnancy-related risk is poor. Best practices in HHT management should be followed to minimize negative effects of the disorder. MDPI 2022-04-13 /pmc/articles/PMC9025602/ /pubmed/35456271 http://dx.doi.org/10.3390/jcm11082178 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Andorfer, Kornelia E. C.
Seebauer, Caroline T.
Dienemann, Carolin
Marcrum, Steven C.
Fischer, René
Bohr, Christopher
Kühnel, Thomas S.
HHT-Related Epistaxis and Pregnancy—A Retrospective Survey and Recommendations for Management from an Otorhinolaryngology Perspective
title HHT-Related Epistaxis and Pregnancy—A Retrospective Survey and Recommendations for Management from an Otorhinolaryngology Perspective
title_full HHT-Related Epistaxis and Pregnancy—A Retrospective Survey and Recommendations for Management from an Otorhinolaryngology Perspective
title_fullStr HHT-Related Epistaxis and Pregnancy—A Retrospective Survey and Recommendations for Management from an Otorhinolaryngology Perspective
title_full_unstemmed HHT-Related Epistaxis and Pregnancy—A Retrospective Survey and Recommendations for Management from an Otorhinolaryngology Perspective
title_short HHT-Related Epistaxis and Pregnancy—A Retrospective Survey and Recommendations for Management from an Otorhinolaryngology Perspective
title_sort hht-related epistaxis and pregnancy—a retrospective survey and recommendations for management from an otorhinolaryngology perspective
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025602/
https://www.ncbi.nlm.nih.gov/pubmed/35456271
http://dx.doi.org/10.3390/jcm11082178
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