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Allergen Tests of Fruit Sensitization Involving Children with Allergic Diseases

Fruit is a kind of plant food which is rich in nutrients and immune-regulating ingredients. A meta-analysis has demonstrated that fruits have a protective effects against asthma. On the other hand, clinical syndromes of allergic reactions to fruits manifest as an oral allergy syndrome. We aimed to i...

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Autores principales: Chang, Ling-Sai, Chang, Hsin-Yu, Yang, Yao-Hsu, Lee, Zon-Min, Guo, Mindy Ming-Huey, Huang, Ying-Hsien, Kuo, Ho-Chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025653/
https://www.ncbi.nlm.nih.gov/pubmed/35455514
http://dx.doi.org/10.3390/children9040470
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author Chang, Ling-Sai
Chang, Hsin-Yu
Yang, Yao-Hsu
Lee, Zon-Min
Guo, Mindy Ming-Huey
Huang, Ying-Hsien
Kuo, Ho-Chang
author_facet Chang, Ling-Sai
Chang, Hsin-Yu
Yang, Yao-Hsu
Lee, Zon-Min
Guo, Mindy Ming-Huey
Huang, Ying-Hsien
Kuo, Ho-Chang
author_sort Chang, Ling-Sai
collection PubMed
description Fruit is a kind of plant food which is rich in nutrients and immune-regulating ingredients. A meta-analysis has demonstrated that fruits have a protective effects against asthma. On the other hand, clinical syndromes of allergic reactions to fruits manifest as an oral allergy syndrome. We aimed to investigate the patterns and associated factors of fruit allergen-specific IgE (sIgE) sensitization among patients with suspected clinical symptoms. Data were extracted from the Chang Gung Research Database. Fruit sensitization in Taiwan was evaluated using the presence of IgE antibodies against specific fruits. The overall prevalence of positive sIgE responses to fruit allergens in Taiwan, in order of decreasing importance, was pineapple, kiwi, banana, and papaya. Children aged 0–18 had a higher positive rate of allergic responses to pineapple, kiwi, banana, and papaya than adults over the age of 18. Positive specific IgE for kiwi, banana, or papaya was more frequent in younger than in older children and children with a higher total IgE of both logarithmic (log) and arithmetic values. The analysis of log IgE for pineapple positive vs. negative children determined an optimal cutoff value, log IgE 2.2, with both sensitivity (0.9) and specificity (0.5). Dermatitis was significantly more prevalent in children with positive IgE for pineapple, kiwi, banana, and papaya than negative specific IgE. The highest positive rate of sIgE against fruits was pineapple among children. Even in older children, the positive rate of pineapple allergens was high. IgE discriminates with and without sIgE for pineapple, with an optimal cutoff of 158.5 U/mL.
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spelling pubmed-90256532022-04-23 Allergen Tests of Fruit Sensitization Involving Children with Allergic Diseases Chang, Ling-Sai Chang, Hsin-Yu Yang, Yao-Hsu Lee, Zon-Min Guo, Mindy Ming-Huey Huang, Ying-Hsien Kuo, Ho-Chang Children (Basel) Article Fruit is a kind of plant food which is rich in nutrients and immune-regulating ingredients. A meta-analysis has demonstrated that fruits have a protective effects against asthma. On the other hand, clinical syndromes of allergic reactions to fruits manifest as an oral allergy syndrome. We aimed to investigate the patterns and associated factors of fruit allergen-specific IgE (sIgE) sensitization among patients with suspected clinical symptoms. Data were extracted from the Chang Gung Research Database. Fruit sensitization in Taiwan was evaluated using the presence of IgE antibodies against specific fruits. The overall prevalence of positive sIgE responses to fruit allergens in Taiwan, in order of decreasing importance, was pineapple, kiwi, banana, and papaya. Children aged 0–18 had a higher positive rate of allergic responses to pineapple, kiwi, banana, and papaya than adults over the age of 18. Positive specific IgE for kiwi, banana, or papaya was more frequent in younger than in older children and children with a higher total IgE of both logarithmic (log) and arithmetic values. The analysis of log IgE for pineapple positive vs. negative children determined an optimal cutoff value, log IgE 2.2, with both sensitivity (0.9) and specificity (0.5). Dermatitis was significantly more prevalent in children with positive IgE for pineapple, kiwi, banana, and papaya than negative specific IgE. The highest positive rate of sIgE against fruits was pineapple among children. Even in older children, the positive rate of pineapple allergens was high. IgE discriminates with and without sIgE for pineapple, with an optimal cutoff of 158.5 U/mL. MDPI 2022-03-28 /pmc/articles/PMC9025653/ /pubmed/35455514 http://dx.doi.org/10.3390/children9040470 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chang, Ling-Sai
Chang, Hsin-Yu
Yang, Yao-Hsu
Lee, Zon-Min
Guo, Mindy Ming-Huey
Huang, Ying-Hsien
Kuo, Ho-Chang
Allergen Tests of Fruit Sensitization Involving Children with Allergic Diseases
title Allergen Tests of Fruit Sensitization Involving Children with Allergic Diseases
title_full Allergen Tests of Fruit Sensitization Involving Children with Allergic Diseases
title_fullStr Allergen Tests of Fruit Sensitization Involving Children with Allergic Diseases
title_full_unstemmed Allergen Tests of Fruit Sensitization Involving Children with Allergic Diseases
title_short Allergen Tests of Fruit Sensitization Involving Children with Allergic Diseases
title_sort allergen tests of fruit sensitization involving children with allergic diseases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025653/
https://www.ncbi.nlm.nih.gov/pubmed/35455514
http://dx.doi.org/10.3390/children9040470
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