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Biocompatibility of Surface-Modified Membranes for Chronic Hemodialysis Therapy

Hemodialysis is a life-sustaining therapy for millions of people worldwide. However, despite considerable technical and scientific improvements, results are still not fully satisfactory in terms of morbidity and mortality. The membrane contained in the hemodialyzer is undoubtedly the main determinan...

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Autores principales: Bonomini, Mario, Piscitani, Luca, Di Liberato, Lorenzo, Sirolli, Vittorio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025662/
https://www.ncbi.nlm.nih.gov/pubmed/35453594
http://dx.doi.org/10.3390/biomedicines10040844
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author Bonomini, Mario
Piscitani, Luca
Di Liberato, Lorenzo
Sirolli, Vittorio
author_facet Bonomini, Mario
Piscitani, Luca
Di Liberato, Lorenzo
Sirolli, Vittorio
author_sort Bonomini, Mario
collection PubMed
description Hemodialysis is a life-sustaining therapy for millions of people worldwide. However, despite considerable technical and scientific improvements, results are still not fully satisfactory in terms of morbidity and mortality. The membrane contained in the hemodialyzer is undoubtedly the main determinant of the success and quality of hemodialysis therapy. Membrane properties influence solute removal and the interactions with blood components that define the membrane’s biocompatibility. Bioincompatibility is considered a potential contributor to several uremic complications. Thus, the development of more biocompatible polymers used as hemodialyzer membrane is of utmost importance for improving results and clinical patient outcomes. Many different surface-modified membranes for hemodialysis have been manufactured over recent years by varying approaches in the attempt to minimize blood incompatibility. Their main characteristics and clinical results in hemodialysis patients were reviewed in the present article.
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spelling pubmed-90256622022-04-23 Biocompatibility of Surface-Modified Membranes for Chronic Hemodialysis Therapy Bonomini, Mario Piscitani, Luca Di Liberato, Lorenzo Sirolli, Vittorio Biomedicines Review Hemodialysis is a life-sustaining therapy for millions of people worldwide. However, despite considerable technical and scientific improvements, results are still not fully satisfactory in terms of morbidity and mortality. The membrane contained in the hemodialyzer is undoubtedly the main determinant of the success and quality of hemodialysis therapy. Membrane properties influence solute removal and the interactions with blood components that define the membrane’s biocompatibility. Bioincompatibility is considered a potential contributor to several uremic complications. Thus, the development of more biocompatible polymers used as hemodialyzer membrane is of utmost importance for improving results and clinical patient outcomes. Many different surface-modified membranes for hemodialysis have been manufactured over recent years by varying approaches in the attempt to minimize blood incompatibility. Their main characteristics and clinical results in hemodialysis patients were reviewed in the present article. MDPI 2022-04-03 /pmc/articles/PMC9025662/ /pubmed/35453594 http://dx.doi.org/10.3390/biomedicines10040844 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bonomini, Mario
Piscitani, Luca
Di Liberato, Lorenzo
Sirolli, Vittorio
Biocompatibility of Surface-Modified Membranes for Chronic Hemodialysis Therapy
title Biocompatibility of Surface-Modified Membranes for Chronic Hemodialysis Therapy
title_full Biocompatibility of Surface-Modified Membranes for Chronic Hemodialysis Therapy
title_fullStr Biocompatibility of Surface-Modified Membranes for Chronic Hemodialysis Therapy
title_full_unstemmed Biocompatibility of Surface-Modified Membranes for Chronic Hemodialysis Therapy
title_short Biocompatibility of Surface-Modified Membranes for Chronic Hemodialysis Therapy
title_sort biocompatibility of surface-modified membranes for chronic hemodialysis therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025662/
https://www.ncbi.nlm.nih.gov/pubmed/35453594
http://dx.doi.org/10.3390/biomedicines10040844
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