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Biocompatibility of Surface-Modified Membranes for Chronic Hemodialysis Therapy
Hemodialysis is a life-sustaining therapy for millions of people worldwide. However, despite considerable technical and scientific improvements, results are still not fully satisfactory in terms of morbidity and mortality. The membrane contained in the hemodialyzer is undoubtedly the main determinan...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025662/ https://www.ncbi.nlm.nih.gov/pubmed/35453594 http://dx.doi.org/10.3390/biomedicines10040844 |
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author | Bonomini, Mario Piscitani, Luca Di Liberato, Lorenzo Sirolli, Vittorio |
author_facet | Bonomini, Mario Piscitani, Luca Di Liberato, Lorenzo Sirolli, Vittorio |
author_sort | Bonomini, Mario |
collection | PubMed |
description | Hemodialysis is a life-sustaining therapy for millions of people worldwide. However, despite considerable technical and scientific improvements, results are still not fully satisfactory in terms of morbidity and mortality. The membrane contained in the hemodialyzer is undoubtedly the main determinant of the success and quality of hemodialysis therapy. Membrane properties influence solute removal and the interactions with blood components that define the membrane’s biocompatibility. Bioincompatibility is considered a potential contributor to several uremic complications. Thus, the development of more biocompatible polymers used as hemodialyzer membrane is of utmost importance for improving results and clinical patient outcomes. Many different surface-modified membranes for hemodialysis have been manufactured over recent years by varying approaches in the attempt to minimize blood incompatibility. Their main characteristics and clinical results in hemodialysis patients were reviewed in the present article. |
format | Online Article Text |
id | pubmed-9025662 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90256622022-04-23 Biocompatibility of Surface-Modified Membranes for Chronic Hemodialysis Therapy Bonomini, Mario Piscitani, Luca Di Liberato, Lorenzo Sirolli, Vittorio Biomedicines Review Hemodialysis is a life-sustaining therapy for millions of people worldwide. However, despite considerable technical and scientific improvements, results are still not fully satisfactory in terms of morbidity and mortality. The membrane contained in the hemodialyzer is undoubtedly the main determinant of the success and quality of hemodialysis therapy. Membrane properties influence solute removal and the interactions with blood components that define the membrane’s biocompatibility. Bioincompatibility is considered a potential contributor to several uremic complications. Thus, the development of more biocompatible polymers used as hemodialyzer membrane is of utmost importance for improving results and clinical patient outcomes. Many different surface-modified membranes for hemodialysis have been manufactured over recent years by varying approaches in the attempt to minimize blood incompatibility. Their main characteristics and clinical results in hemodialysis patients were reviewed in the present article. MDPI 2022-04-03 /pmc/articles/PMC9025662/ /pubmed/35453594 http://dx.doi.org/10.3390/biomedicines10040844 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Bonomini, Mario Piscitani, Luca Di Liberato, Lorenzo Sirolli, Vittorio Biocompatibility of Surface-Modified Membranes for Chronic Hemodialysis Therapy |
title | Biocompatibility of Surface-Modified Membranes for Chronic Hemodialysis Therapy |
title_full | Biocompatibility of Surface-Modified Membranes for Chronic Hemodialysis Therapy |
title_fullStr | Biocompatibility of Surface-Modified Membranes for Chronic Hemodialysis Therapy |
title_full_unstemmed | Biocompatibility of Surface-Modified Membranes for Chronic Hemodialysis Therapy |
title_short | Biocompatibility of Surface-Modified Membranes for Chronic Hemodialysis Therapy |
title_sort | biocompatibility of surface-modified membranes for chronic hemodialysis therapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025662/ https://www.ncbi.nlm.nih.gov/pubmed/35453594 http://dx.doi.org/10.3390/biomedicines10040844 |
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