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Possible Interactions between Malaria, Helminthiases and the Gut Microbiota: A Short Review

Malaria, caused by the Plasmodium species, is an infectious disease responsible for more than 600 thousand deaths and more than 200 million morbidity cases annually. With above 90% of those deaths and cases, sub-Saharan Africa is affected disproportionately. Malaria clinical manifestations range fro...

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Autores principales: Mutoni, Jean d’Amour, Coutelier, Jean-Paul, Rujeni, Nadine, Mutesa, Leon, Cani, Patrice D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025727/
https://www.ncbi.nlm.nih.gov/pubmed/35456772
http://dx.doi.org/10.3390/microorganisms10040721
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author Mutoni, Jean d’Amour
Coutelier, Jean-Paul
Rujeni, Nadine
Mutesa, Leon
Cani, Patrice D.
author_facet Mutoni, Jean d’Amour
Coutelier, Jean-Paul
Rujeni, Nadine
Mutesa, Leon
Cani, Patrice D.
author_sort Mutoni, Jean d’Amour
collection PubMed
description Malaria, caused by the Plasmodium species, is an infectious disease responsible for more than 600 thousand deaths and more than 200 million morbidity cases annually. With above 90% of those deaths and cases, sub-Saharan Africa is affected disproportionately. Malaria clinical manifestations range from asymptomatic to simple, mild, and severe disease. External factors such as the gut microbiota and helminthiases have been shown to affect malaria clinical manifestations. However, little is known about whether the gut microbiota has the potential to influence malaria clinical manifestations in humans. Similarly, many previous studies have shown divergent results on the effects of helminths on malaria clinical manifestations. To date, a few studies, mainly murine, have shown the gut microbiota’s capacity to modulate malaria’s prospective risk of infection, transmission, and severity. This short review seeks to summarize recent literature about possible interactions between malaria, helminthiases, and the gut microbiota. The knowledge from this exercise will inform innovation possibilities for future tools, technologies, approaches, and policies around the prevention and management of malaria in endemic countries.
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spelling pubmed-90257272022-04-23 Possible Interactions between Malaria, Helminthiases and the Gut Microbiota: A Short Review Mutoni, Jean d’Amour Coutelier, Jean-Paul Rujeni, Nadine Mutesa, Leon Cani, Patrice D. Microorganisms Review Malaria, caused by the Plasmodium species, is an infectious disease responsible for more than 600 thousand deaths and more than 200 million morbidity cases annually. With above 90% of those deaths and cases, sub-Saharan Africa is affected disproportionately. Malaria clinical manifestations range from asymptomatic to simple, mild, and severe disease. External factors such as the gut microbiota and helminthiases have been shown to affect malaria clinical manifestations. However, little is known about whether the gut microbiota has the potential to influence malaria clinical manifestations in humans. Similarly, many previous studies have shown divergent results on the effects of helminths on malaria clinical manifestations. To date, a few studies, mainly murine, have shown the gut microbiota’s capacity to modulate malaria’s prospective risk of infection, transmission, and severity. This short review seeks to summarize recent literature about possible interactions between malaria, helminthiases, and the gut microbiota. The knowledge from this exercise will inform innovation possibilities for future tools, technologies, approaches, and policies around the prevention and management of malaria in endemic countries. MDPI 2022-03-27 /pmc/articles/PMC9025727/ /pubmed/35456772 http://dx.doi.org/10.3390/microorganisms10040721 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mutoni, Jean d’Amour
Coutelier, Jean-Paul
Rujeni, Nadine
Mutesa, Leon
Cani, Patrice D.
Possible Interactions between Malaria, Helminthiases and the Gut Microbiota: A Short Review
title Possible Interactions between Malaria, Helminthiases and the Gut Microbiota: A Short Review
title_full Possible Interactions between Malaria, Helminthiases and the Gut Microbiota: A Short Review
title_fullStr Possible Interactions between Malaria, Helminthiases and the Gut Microbiota: A Short Review
title_full_unstemmed Possible Interactions between Malaria, Helminthiases and the Gut Microbiota: A Short Review
title_short Possible Interactions between Malaria, Helminthiases and the Gut Microbiota: A Short Review
title_sort possible interactions between malaria, helminthiases and the gut microbiota: a short review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025727/
https://www.ncbi.nlm.nih.gov/pubmed/35456772
http://dx.doi.org/10.3390/microorganisms10040721
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