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Fundamental Aspects of Lipid-Based Excipients in Lipid-Based Product Development
Poor aqueous solubility of drugs is still a foremost challenge in pharmaceutical product development. The use of lipids in designing formulations provides an opportunity to enhance the aqueous solubility and consequently bioavailability of drugs. Pre-dissolution of drugs in lipids, surfactants, or m...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025782/ https://www.ncbi.nlm.nih.gov/pubmed/35456665 http://dx.doi.org/10.3390/pharmaceutics14040831 |
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author | Nakmode, Deepa Bhavana, Valamla Thakor, Pradip Madan, Jitender Singh, Pankaj Kumar Singh, Shashi Bala Rosenholm, Jessica M. Bansal, Kuldeep K. Mehra, Neelesh Kumar |
author_facet | Nakmode, Deepa Bhavana, Valamla Thakor, Pradip Madan, Jitender Singh, Pankaj Kumar Singh, Shashi Bala Rosenholm, Jessica M. Bansal, Kuldeep K. Mehra, Neelesh Kumar |
author_sort | Nakmode, Deepa |
collection | PubMed |
description | Poor aqueous solubility of drugs is still a foremost challenge in pharmaceutical product development. The use of lipids in designing formulations provides an opportunity to enhance the aqueous solubility and consequently bioavailability of drugs. Pre-dissolution of drugs in lipids, surfactants, or mixtures of lipid excipients and surfactants eliminate the dissolution/dissolving step, which is likely to be the rate-limiting factor for oral absorption of poorly water-soluble drugs. In this review, we exhaustively summarize the lipids excipients in relation to their classification, absorption mechanisms, and lipid-based product development. Methodologies utilized for the preparation of solid and semi-solid lipid formulations, applications, phase behaviour, and regulatory perspective of lipid excipients are discussed. |
format | Online Article Text |
id | pubmed-9025782 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90257822022-04-23 Fundamental Aspects of Lipid-Based Excipients in Lipid-Based Product Development Nakmode, Deepa Bhavana, Valamla Thakor, Pradip Madan, Jitender Singh, Pankaj Kumar Singh, Shashi Bala Rosenholm, Jessica M. Bansal, Kuldeep K. Mehra, Neelesh Kumar Pharmaceutics Review Poor aqueous solubility of drugs is still a foremost challenge in pharmaceutical product development. The use of lipids in designing formulations provides an opportunity to enhance the aqueous solubility and consequently bioavailability of drugs. Pre-dissolution of drugs in lipids, surfactants, or mixtures of lipid excipients and surfactants eliminate the dissolution/dissolving step, which is likely to be the rate-limiting factor for oral absorption of poorly water-soluble drugs. In this review, we exhaustively summarize the lipids excipients in relation to their classification, absorption mechanisms, and lipid-based product development. Methodologies utilized for the preparation of solid and semi-solid lipid formulations, applications, phase behaviour, and regulatory perspective of lipid excipients are discussed. MDPI 2022-04-11 /pmc/articles/PMC9025782/ /pubmed/35456665 http://dx.doi.org/10.3390/pharmaceutics14040831 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Nakmode, Deepa Bhavana, Valamla Thakor, Pradip Madan, Jitender Singh, Pankaj Kumar Singh, Shashi Bala Rosenholm, Jessica M. Bansal, Kuldeep K. Mehra, Neelesh Kumar Fundamental Aspects of Lipid-Based Excipients in Lipid-Based Product Development |
title | Fundamental Aspects of Lipid-Based Excipients in Lipid-Based Product Development |
title_full | Fundamental Aspects of Lipid-Based Excipients in Lipid-Based Product Development |
title_fullStr | Fundamental Aspects of Lipid-Based Excipients in Lipid-Based Product Development |
title_full_unstemmed | Fundamental Aspects of Lipid-Based Excipients in Lipid-Based Product Development |
title_short | Fundamental Aspects of Lipid-Based Excipients in Lipid-Based Product Development |
title_sort | fundamental aspects of lipid-based excipients in lipid-based product development |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025782/ https://www.ncbi.nlm.nih.gov/pubmed/35456665 http://dx.doi.org/10.3390/pharmaceutics14040831 |
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