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Fundamental Aspects of Lipid-Based Excipients in Lipid-Based Product Development

Poor aqueous solubility of drugs is still a foremost challenge in pharmaceutical product development. The use of lipids in designing formulations provides an opportunity to enhance the aqueous solubility and consequently bioavailability of drugs. Pre-dissolution of drugs in lipids, surfactants, or m...

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Autores principales: Nakmode, Deepa, Bhavana, Valamla, Thakor, Pradip, Madan, Jitender, Singh, Pankaj Kumar, Singh, Shashi Bala, Rosenholm, Jessica M., Bansal, Kuldeep K., Mehra, Neelesh Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025782/
https://www.ncbi.nlm.nih.gov/pubmed/35456665
http://dx.doi.org/10.3390/pharmaceutics14040831
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author Nakmode, Deepa
Bhavana, Valamla
Thakor, Pradip
Madan, Jitender
Singh, Pankaj Kumar
Singh, Shashi Bala
Rosenholm, Jessica M.
Bansal, Kuldeep K.
Mehra, Neelesh Kumar
author_facet Nakmode, Deepa
Bhavana, Valamla
Thakor, Pradip
Madan, Jitender
Singh, Pankaj Kumar
Singh, Shashi Bala
Rosenholm, Jessica M.
Bansal, Kuldeep K.
Mehra, Neelesh Kumar
author_sort Nakmode, Deepa
collection PubMed
description Poor aqueous solubility of drugs is still a foremost challenge in pharmaceutical product development. The use of lipids in designing formulations provides an opportunity to enhance the aqueous solubility and consequently bioavailability of drugs. Pre-dissolution of drugs in lipids, surfactants, or mixtures of lipid excipients and surfactants eliminate the dissolution/dissolving step, which is likely to be the rate-limiting factor for oral absorption of poorly water-soluble drugs. In this review, we exhaustively summarize the lipids excipients in relation to their classification, absorption mechanisms, and lipid-based product development. Methodologies utilized for the preparation of solid and semi-solid lipid formulations, applications, phase behaviour, and regulatory perspective of lipid excipients are discussed.
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spelling pubmed-90257822022-04-23 Fundamental Aspects of Lipid-Based Excipients in Lipid-Based Product Development Nakmode, Deepa Bhavana, Valamla Thakor, Pradip Madan, Jitender Singh, Pankaj Kumar Singh, Shashi Bala Rosenholm, Jessica M. Bansal, Kuldeep K. Mehra, Neelesh Kumar Pharmaceutics Review Poor aqueous solubility of drugs is still a foremost challenge in pharmaceutical product development. The use of lipids in designing formulations provides an opportunity to enhance the aqueous solubility and consequently bioavailability of drugs. Pre-dissolution of drugs in lipids, surfactants, or mixtures of lipid excipients and surfactants eliminate the dissolution/dissolving step, which is likely to be the rate-limiting factor for oral absorption of poorly water-soluble drugs. In this review, we exhaustively summarize the lipids excipients in relation to their classification, absorption mechanisms, and lipid-based product development. Methodologies utilized for the preparation of solid and semi-solid lipid formulations, applications, phase behaviour, and regulatory perspective of lipid excipients are discussed. MDPI 2022-04-11 /pmc/articles/PMC9025782/ /pubmed/35456665 http://dx.doi.org/10.3390/pharmaceutics14040831 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Nakmode, Deepa
Bhavana, Valamla
Thakor, Pradip
Madan, Jitender
Singh, Pankaj Kumar
Singh, Shashi Bala
Rosenholm, Jessica M.
Bansal, Kuldeep K.
Mehra, Neelesh Kumar
Fundamental Aspects of Lipid-Based Excipients in Lipid-Based Product Development
title Fundamental Aspects of Lipid-Based Excipients in Lipid-Based Product Development
title_full Fundamental Aspects of Lipid-Based Excipients in Lipid-Based Product Development
title_fullStr Fundamental Aspects of Lipid-Based Excipients in Lipid-Based Product Development
title_full_unstemmed Fundamental Aspects of Lipid-Based Excipients in Lipid-Based Product Development
title_short Fundamental Aspects of Lipid-Based Excipients in Lipid-Based Product Development
title_sort fundamental aspects of lipid-based excipients in lipid-based product development
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025782/
https://www.ncbi.nlm.nih.gov/pubmed/35456665
http://dx.doi.org/10.3390/pharmaceutics14040831
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