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Compassionate Treatment of Brainstem Tumors with Boron Neutron Capture Therapy: A Case Series
Brainstem tumors are heterogenous and cancerous glioma tumors arising from the midbrain, pons, and the medulla that are relatively common in children, accounting for 10% to 20% of all pediatric brain tumors. However, the prognosis of aggressive brainstem gliomas remains extremely poor despite aggres...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025803/ https://www.ncbi.nlm.nih.gov/pubmed/35455057 http://dx.doi.org/10.3390/life12040566 |
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author | Chen, Yi-Wei Lee, Yi-Yen Lin, Chun-Fu Huang, Ting-Yu Ke, Shih-Hung Mu, Pei-Fan Pan, Po-Shen Chen, Jen-Kun Lan, Tien-Li Hsu, Ping-Chuan Liang, Muh-Lii Chen, Hsin-Hung Chang, Feng-Chi Wu, Chih-Chun Lin, Shih-Chieh Lee, Jia-Cheng Chen, Shih-Kuan Liu, Hong-Ming Peir, Jinn-Jer Tsai, Hui-Yu Lin, Ko-Han Peng, Nan-Jing Chen, Kuan-Hsuan Wu, Yuan-Hung Kang, Yu-Mei Yang, Wan-Chin Liou, Shueh-Chun Huang, Wei-Hsuan Tanaka, Hiroki Wong, Tai-Tong Chao, Yee Chou, Fong-In |
author_facet | Chen, Yi-Wei Lee, Yi-Yen Lin, Chun-Fu Huang, Ting-Yu Ke, Shih-Hung Mu, Pei-Fan Pan, Po-Shen Chen, Jen-Kun Lan, Tien-Li Hsu, Ping-Chuan Liang, Muh-Lii Chen, Hsin-Hung Chang, Feng-Chi Wu, Chih-Chun Lin, Shih-Chieh Lee, Jia-Cheng Chen, Shih-Kuan Liu, Hong-Ming Peir, Jinn-Jer Tsai, Hui-Yu Lin, Ko-Han Peng, Nan-Jing Chen, Kuan-Hsuan Wu, Yuan-Hung Kang, Yu-Mei Yang, Wan-Chin Liou, Shueh-Chun Huang, Wei-Hsuan Tanaka, Hiroki Wong, Tai-Tong Chao, Yee Chou, Fong-In |
author_sort | Chen, Yi-Wei |
collection | PubMed |
description | Brainstem tumors are heterogenous and cancerous glioma tumors arising from the midbrain, pons, and the medulla that are relatively common in children, accounting for 10% to 20% of all pediatric brain tumors. However, the prognosis of aggressive brainstem gliomas remains extremely poor despite aggressive treatment with chemotherapy and radiotherapy. That means there are many life-threatening patients who have exhausted all available treatment options and are beginning to face end-of-life stage. Therefore, the unique properties of highly selective heavy particle irradiation with boron neutron capture therapy (BNCT) may be well suited to prolong the lives of patients with end-stage brainstem gliomas. Herein, we report a case series of life-threatening patients with end-stage brainstem glioma who eligible for Emergency and Compassionate Use, in whom we performed a scheduled two fractions of salvage BNCT strategy with low treatment dosage each time. No patients experienced acute or late adverse events related to BNCT. There were 3 patients who relapsed after two fractionated BNCT treatment, characterized by younger age, lower T/N ratio, and receiving lower treatment dose. Therefore, two fractionated low-dose BNCT may be a promising treatment for end-stage brainstem tumors. For younger patients with low T/N ratios, more fractionated low-dose BNCT should be considered. |
format | Online Article Text |
id | pubmed-9025803 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90258032022-04-23 Compassionate Treatment of Brainstem Tumors with Boron Neutron Capture Therapy: A Case Series Chen, Yi-Wei Lee, Yi-Yen Lin, Chun-Fu Huang, Ting-Yu Ke, Shih-Hung Mu, Pei-Fan Pan, Po-Shen Chen, Jen-Kun Lan, Tien-Li Hsu, Ping-Chuan Liang, Muh-Lii Chen, Hsin-Hung Chang, Feng-Chi Wu, Chih-Chun Lin, Shih-Chieh Lee, Jia-Cheng Chen, Shih-Kuan Liu, Hong-Ming Peir, Jinn-Jer Tsai, Hui-Yu Lin, Ko-Han Peng, Nan-Jing Chen, Kuan-Hsuan Wu, Yuan-Hung Kang, Yu-Mei Yang, Wan-Chin Liou, Shueh-Chun Huang, Wei-Hsuan Tanaka, Hiroki Wong, Tai-Tong Chao, Yee Chou, Fong-In Life (Basel) Case Report Brainstem tumors are heterogenous and cancerous glioma tumors arising from the midbrain, pons, and the medulla that are relatively common in children, accounting for 10% to 20% of all pediatric brain tumors. However, the prognosis of aggressive brainstem gliomas remains extremely poor despite aggressive treatment with chemotherapy and radiotherapy. That means there are many life-threatening patients who have exhausted all available treatment options and are beginning to face end-of-life stage. Therefore, the unique properties of highly selective heavy particle irradiation with boron neutron capture therapy (BNCT) may be well suited to prolong the lives of patients with end-stage brainstem gliomas. Herein, we report a case series of life-threatening patients with end-stage brainstem glioma who eligible for Emergency and Compassionate Use, in whom we performed a scheduled two fractions of salvage BNCT strategy with low treatment dosage each time. No patients experienced acute or late adverse events related to BNCT. There were 3 patients who relapsed after two fractionated BNCT treatment, characterized by younger age, lower T/N ratio, and receiving lower treatment dose. Therefore, two fractionated low-dose BNCT may be a promising treatment for end-stage brainstem tumors. For younger patients with low T/N ratios, more fractionated low-dose BNCT should be considered. MDPI 2022-04-10 /pmc/articles/PMC9025803/ /pubmed/35455057 http://dx.doi.org/10.3390/life12040566 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Chen, Yi-Wei Lee, Yi-Yen Lin, Chun-Fu Huang, Ting-Yu Ke, Shih-Hung Mu, Pei-Fan Pan, Po-Shen Chen, Jen-Kun Lan, Tien-Li Hsu, Ping-Chuan Liang, Muh-Lii Chen, Hsin-Hung Chang, Feng-Chi Wu, Chih-Chun Lin, Shih-Chieh Lee, Jia-Cheng Chen, Shih-Kuan Liu, Hong-Ming Peir, Jinn-Jer Tsai, Hui-Yu Lin, Ko-Han Peng, Nan-Jing Chen, Kuan-Hsuan Wu, Yuan-Hung Kang, Yu-Mei Yang, Wan-Chin Liou, Shueh-Chun Huang, Wei-Hsuan Tanaka, Hiroki Wong, Tai-Tong Chao, Yee Chou, Fong-In Compassionate Treatment of Brainstem Tumors with Boron Neutron Capture Therapy: A Case Series |
title | Compassionate Treatment of Brainstem Tumors with Boron Neutron Capture Therapy: A Case Series |
title_full | Compassionate Treatment of Brainstem Tumors with Boron Neutron Capture Therapy: A Case Series |
title_fullStr | Compassionate Treatment of Brainstem Tumors with Boron Neutron Capture Therapy: A Case Series |
title_full_unstemmed | Compassionate Treatment of Brainstem Tumors with Boron Neutron Capture Therapy: A Case Series |
title_short | Compassionate Treatment of Brainstem Tumors with Boron Neutron Capture Therapy: A Case Series |
title_sort | compassionate treatment of brainstem tumors with boron neutron capture therapy: a case series |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025803/ https://www.ncbi.nlm.nih.gov/pubmed/35455057 http://dx.doi.org/10.3390/life12040566 |
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