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Compassionate Treatment of Brainstem Tumors with Boron Neutron Capture Therapy: A Case Series

Brainstem tumors are heterogenous and cancerous glioma tumors arising from the midbrain, pons, and the medulla that are relatively common in children, accounting for 10% to 20% of all pediatric brain tumors. However, the prognosis of aggressive brainstem gliomas remains extremely poor despite aggres...

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Autores principales: Chen, Yi-Wei, Lee, Yi-Yen, Lin, Chun-Fu, Huang, Ting-Yu, Ke, Shih-Hung, Mu, Pei-Fan, Pan, Po-Shen, Chen, Jen-Kun, Lan, Tien-Li, Hsu, Ping-Chuan, Liang, Muh-Lii, Chen, Hsin-Hung, Chang, Feng-Chi, Wu, Chih-Chun, Lin, Shih-Chieh, Lee, Jia-Cheng, Chen, Shih-Kuan, Liu, Hong-Ming, Peir, Jinn-Jer, Tsai, Hui-Yu, Lin, Ko-Han, Peng, Nan-Jing, Chen, Kuan-Hsuan, Wu, Yuan-Hung, Kang, Yu-Mei, Yang, Wan-Chin, Liou, Shueh-Chun, Huang, Wei-Hsuan, Tanaka, Hiroki, Wong, Tai-Tong, Chao, Yee, Chou, Fong-In
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025803/
https://www.ncbi.nlm.nih.gov/pubmed/35455057
http://dx.doi.org/10.3390/life12040566
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author Chen, Yi-Wei
Lee, Yi-Yen
Lin, Chun-Fu
Huang, Ting-Yu
Ke, Shih-Hung
Mu, Pei-Fan
Pan, Po-Shen
Chen, Jen-Kun
Lan, Tien-Li
Hsu, Ping-Chuan
Liang, Muh-Lii
Chen, Hsin-Hung
Chang, Feng-Chi
Wu, Chih-Chun
Lin, Shih-Chieh
Lee, Jia-Cheng
Chen, Shih-Kuan
Liu, Hong-Ming
Peir, Jinn-Jer
Tsai, Hui-Yu
Lin, Ko-Han
Peng, Nan-Jing
Chen, Kuan-Hsuan
Wu, Yuan-Hung
Kang, Yu-Mei
Yang, Wan-Chin
Liou, Shueh-Chun
Huang, Wei-Hsuan
Tanaka, Hiroki
Wong, Tai-Tong
Chao, Yee
Chou, Fong-In
author_facet Chen, Yi-Wei
Lee, Yi-Yen
Lin, Chun-Fu
Huang, Ting-Yu
Ke, Shih-Hung
Mu, Pei-Fan
Pan, Po-Shen
Chen, Jen-Kun
Lan, Tien-Li
Hsu, Ping-Chuan
Liang, Muh-Lii
Chen, Hsin-Hung
Chang, Feng-Chi
Wu, Chih-Chun
Lin, Shih-Chieh
Lee, Jia-Cheng
Chen, Shih-Kuan
Liu, Hong-Ming
Peir, Jinn-Jer
Tsai, Hui-Yu
Lin, Ko-Han
Peng, Nan-Jing
Chen, Kuan-Hsuan
Wu, Yuan-Hung
Kang, Yu-Mei
Yang, Wan-Chin
Liou, Shueh-Chun
Huang, Wei-Hsuan
Tanaka, Hiroki
Wong, Tai-Tong
Chao, Yee
Chou, Fong-In
author_sort Chen, Yi-Wei
collection PubMed
description Brainstem tumors are heterogenous and cancerous glioma tumors arising from the midbrain, pons, and the medulla that are relatively common in children, accounting for 10% to 20% of all pediatric brain tumors. However, the prognosis of aggressive brainstem gliomas remains extremely poor despite aggressive treatment with chemotherapy and radiotherapy. That means there are many life-threatening patients who have exhausted all available treatment options and are beginning to face end-of-life stage. Therefore, the unique properties of highly selective heavy particle irradiation with boron neutron capture therapy (BNCT) may be well suited to prolong the lives of patients with end-stage brainstem gliomas. Herein, we report a case series of life-threatening patients with end-stage brainstem glioma who eligible for Emergency and Compassionate Use, in whom we performed a scheduled two fractions of salvage BNCT strategy with low treatment dosage each time. No patients experienced acute or late adverse events related to BNCT. There were 3 patients who relapsed after two fractionated BNCT treatment, characterized by younger age, lower T/N ratio, and receiving lower treatment dose. Therefore, two fractionated low-dose BNCT may be a promising treatment for end-stage brainstem tumors. For younger patients with low T/N ratios, more fractionated low-dose BNCT should be considered.
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spelling pubmed-90258032022-04-23 Compassionate Treatment of Brainstem Tumors with Boron Neutron Capture Therapy: A Case Series Chen, Yi-Wei Lee, Yi-Yen Lin, Chun-Fu Huang, Ting-Yu Ke, Shih-Hung Mu, Pei-Fan Pan, Po-Shen Chen, Jen-Kun Lan, Tien-Li Hsu, Ping-Chuan Liang, Muh-Lii Chen, Hsin-Hung Chang, Feng-Chi Wu, Chih-Chun Lin, Shih-Chieh Lee, Jia-Cheng Chen, Shih-Kuan Liu, Hong-Ming Peir, Jinn-Jer Tsai, Hui-Yu Lin, Ko-Han Peng, Nan-Jing Chen, Kuan-Hsuan Wu, Yuan-Hung Kang, Yu-Mei Yang, Wan-Chin Liou, Shueh-Chun Huang, Wei-Hsuan Tanaka, Hiroki Wong, Tai-Tong Chao, Yee Chou, Fong-In Life (Basel) Case Report Brainstem tumors are heterogenous and cancerous glioma tumors arising from the midbrain, pons, and the medulla that are relatively common in children, accounting for 10% to 20% of all pediatric brain tumors. However, the prognosis of aggressive brainstem gliomas remains extremely poor despite aggressive treatment with chemotherapy and radiotherapy. That means there are many life-threatening patients who have exhausted all available treatment options and are beginning to face end-of-life stage. Therefore, the unique properties of highly selective heavy particle irradiation with boron neutron capture therapy (BNCT) may be well suited to prolong the lives of patients with end-stage brainstem gliomas. Herein, we report a case series of life-threatening patients with end-stage brainstem glioma who eligible for Emergency and Compassionate Use, in whom we performed a scheduled two fractions of salvage BNCT strategy with low treatment dosage each time. No patients experienced acute or late adverse events related to BNCT. There were 3 patients who relapsed after two fractionated BNCT treatment, characterized by younger age, lower T/N ratio, and receiving lower treatment dose. Therefore, two fractionated low-dose BNCT may be a promising treatment for end-stage brainstem tumors. For younger patients with low T/N ratios, more fractionated low-dose BNCT should be considered. MDPI 2022-04-10 /pmc/articles/PMC9025803/ /pubmed/35455057 http://dx.doi.org/10.3390/life12040566 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Chen, Yi-Wei
Lee, Yi-Yen
Lin, Chun-Fu
Huang, Ting-Yu
Ke, Shih-Hung
Mu, Pei-Fan
Pan, Po-Shen
Chen, Jen-Kun
Lan, Tien-Li
Hsu, Ping-Chuan
Liang, Muh-Lii
Chen, Hsin-Hung
Chang, Feng-Chi
Wu, Chih-Chun
Lin, Shih-Chieh
Lee, Jia-Cheng
Chen, Shih-Kuan
Liu, Hong-Ming
Peir, Jinn-Jer
Tsai, Hui-Yu
Lin, Ko-Han
Peng, Nan-Jing
Chen, Kuan-Hsuan
Wu, Yuan-Hung
Kang, Yu-Mei
Yang, Wan-Chin
Liou, Shueh-Chun
Huang, Wei-Hsuan
Tanaka, Hiroki
Wong, Tai-Tong
Chao, Yee
Chou, Fong-In
Compassionate Treatment of Brainstem Tumors with Boron Neutron Capture Therapy: A Case Series
title Compassionate Treatment of Brainstem Tumors with Boron Neutron Capture Therapy: A Case Series
title_full Compassionate Treatment of Brainstem Tumors with Boron Neutron Capture Therapy: A Case Series
title_fullStr Compassionate Treatment of Brainstem Tumors with Boron Neutron Capture Therapy: A Case Series
title_full_unstemmed Compassionate Treatment of Brainstem Tumors with Boron Neutron Capture Therapy: A Case Series
title_short Compassionate Treatment of Brainstem Tumors with Boron Neutron Capture Therapy: A Case Series
title_sort compassionate treatment of brainstem tumors with boron neutron capture therapy: a case series
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025803/
https://www.ncbi.nlm.nih.gov/pubmed/35455057
http://dx.doi.org/10.3390/life12040566
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