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Lymphatic Tissue Bioengineering for the Treatment of Postsurgical Lymphedema

Lymphedema is characterized by progressive and chronic tissue swelling and inflammation from local accumulation of interstitial fluid due to lymphatic injury or dysfunction. It is a debilitating condition that significantly impacts a patient’s quality of life, and has limited treatment options. With...

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Detalles Bibliográficos
Autores principales: Sung, Cynthia J., Gupta, Kshitij, Wang, Jin, Wong, Alex K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025804/
https://www.ncbi.nlm.nih.gov/pubmed/35447722
http://dx.doi.org/10.3390/bioengineering9040162
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author Sung, Cynthia J.
Gupta, Kshitij
Wang, Jin
Wong, Alex K.
author_facet Sung, Cynthia J.
Gupta, Kshitij
Wang, Jin
Wong, Alex K.
author_sort Sung, Cynthia J.
collection PubMed
description Lymphedema is characterized by progressive and chronic tissue swelling and inflammation from local accumulation of interstitial fluid due to lymphatic injury or dysfunction. It is a debilitating condition that significantly impacts a patient’s quality of life, and has limited treatment options. With better understanding of the molecular mechanisms and pathophysiology of lymphedema and advances in tissue engineering technologies, lymphatic tissue bioengineering and regeneration have emerged as a potential therapeutic option for postsurgical lymphedema. Various strategies involving stem cells, lymphangiogenic factors, bioengineered matrices and mechanical stimuli allow more precisely controlled regeneration of lymphatic tissue at the site of lymphedema without subjecting patients to complications or iatrogenic injuries associated with surgeries. This review provides an overview of current innovative approaches of lymphatic tissue bioengineering that represent a promising treatment option for postsurgical lymphedema.
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spelling pubmed-90258042022-04-23 Lymphatic Tissue Bioengineering for the Treatment of Postsurgical Lymphedema Sung, Cynthia J. Gupta, Kshitij Wang, Jin Wong, Alex K. Bioengineering (Basel) Review Lymphedema is characterized by progressive and chronic tissue swelling and inflammation from local accumulation of interstitial fluid due to lymphatic injury or dysfunction. It is a debilitating condition that significantly impacts a patient’s quality of life, and has limited treatment options. With better understanding of the molecular mechanisms and pathophysiology of lymphedema and advances in tissue engineering technologies, lymphatic tissue bioengineering and regeneration have emerged as a potential therapeutic option for postsurgical lymphedema. Various strategies involving stem cells, lymphangiogenic factors, bioengineered matrices and mechanical stimuli allow more precisely controlled regeneration of lymphatic tissue at the site of lymphedema without subjecting patients to complications or iatrogenic injuries associated with surgeries. This review provides an overview of current innovative approaches of lymphatic tissue bioengineering that represent a promising treatment option for postsurgical lymphedema. MDPI 2022-04-06 /pmc/articles/PMC9025804/ /pubmed/35447722 http://dx.doi.org/10.3390/bioengineering9040162 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sung, Cynthia J.
Gupta, Kshitij
Wang, Jin
Wong, Alex K.
Lymphatic Tissue Bioengineering for the Treatment of Postsurgical Lymphedema
title Lymphatic Tissue Bioengineering for the Treatment of Postsurgical Lymphedema
title_full Lymphatic Tissue Bioengineering for the Treatment of Postsurgical Lymphedema
title_fullStr Lymphatic Tissue Bioengineering for the Treatment of Postsurgical Lymphedema
title_full_unstemmed Lymphatic Tissue Bioengineering for the Treatment of Postsurgical Lymphedema
title_short Lymphatic Tissue Bioengineering for the Treatment of Postsurgical Lymphedema
title_sort lymphatic tissue bioengineering for the treatment of postsurgical lymphedema
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025804/
https://www.ncbi.nlm.nih.gov/pubmed/35447722
http://dx.doi.org/10.3390/bioengineering9040162
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