New Genetic Bomb Trigger: Design, Synthesis, Molecular Dynamics Simulation, and Biological Evaluation of Novel BIBR1532-Related Analogs Targeting Telomerase against Non-Small Cell Lung Cancer

Telomeres serve a critical function in cell replication and proliferation at every stage of the cell cycle. Telomerase is a ribonucleoprotein, responsible for maintaining the telomere length and chromosomal integrity of frequently dividing cells. Although it is silenced in most human somatic cells,...

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Detalles Bibliográficos
Autores principales: Tawfik, Haytham O., El-Hamaky, Anwar A., El-Bastawissy, Eman A., Shcherbakov, Kirill A., Veselovsky, Alexander V., Gladilina, Yulia A., Zhdanov, Dmitry D., El-Hamamsy, Mervat H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025901/
https://www.ncbi.nlm.nih.gov/pubmed/35455478
http://dx.doi.org/10.3390/ph15040481

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