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Endothelial Dysfunction and Cardiovascular Risk in Obstructive Sleep Apnea: A Review Article
Obstructive sleep apnea (OSA) is a respiratory condition during sleep caused by repeated pauses in breathing due to upper airway obstruction. It is estimated that OSA affects 30% of the population, but only 10% are well diagnosed due to the absence of a well-defined symptomatology and poor screening...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025914/ https://www.ncbi.nlm.nih.gov/pubmed/35455027 http://dx.doi.org/10.3390/life12040537 |
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author | Peracaula, Miriam Torres, Daniela Poyatos, Paula Luque, Neus Rojas, Eric Obrador, Anton Orriols, Ramon Tura-Ceide, Olga |
author_facet | Peracaula, Miriam Torres, Daniela Poyatos, Paula Luque, Neus Rojas, Eric Obrador, Anton Orriols, Ramon Tura-Ceide, Olga |
author_sort | Peracaula, Miriam |
collection | PubMed |
description | Obstructive sleep apnea (OSA) is a respiratory condition during sleep caused by repeated pauses in breathing due to upper airway obstruction. It is estimated that OSA affects 30% of the population, but only 10% are well diagnosed due to the absence of a well-defined symptomatology and poor screening tools for early diagnosis. OSA is associated to an endothelial dysfunction inducing several biological responses such as hypoxia, hypercapnia and oxidative stress, among others. OSA also triggers respiratory, nervous, metabolic, humoral and immunity system activations that increase the possibility of suffering a cardiovascular (CV) disease. In this review, we expose different studies that show the relationship between OSA and endothelial dysfunction and its association with CV pathologies like hypertension, and we define the most well-known treatments and their limitations. Additionally, we describe the potential future directions in OSA research, and we report clinical features such as endothelial progenitor cell alterations that could act as biomarkers for the development of new diagnostic tools and target therapies. |
format | Online Article Text |
id | pubmed-9025914 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90259142022-04-23 Endothelial Dysfunction and Cardiovascular Risk in Obstructive Sleep Apnea: A Review Article Peracaula, Miriam Torres, Daniela Poyatos, Paula Luque, Neus Rojas, Eric Obrador, Anton Orriols, Ramon Tura-Ceide, Olga Life (Basel) Review Obstructive sleep apnea (OSA) is a respiratory condition during sleep caused by repeated pauses in breathing due to upper airway obstruction. It is estimated that OSA affects 30% of the population, but only 10% are well diagnosed due to the absence of a well-defined symptomatology and poor screening tools for early diagnosis. OSA is associated to an endothelial dysfunction inducing several biological responses such as hypoxia, hypercapnia and oxidative stress, among others. OSA also triggers respiratory, nervous, metabolic, humoral and immunity system activations that increase the possibility of suffering a cardiovascular (CV) disease. In this review, we expose different studies that show the relationship between OSA and endothelial dysfunction and its association with CV pathologies like hypertension, and we define the most well-known treatments and their limitations. Additionally, we describe the potential future directions in OSA research, and we report clinical features such as endothelial progenitor cell alterations that could act as biomarkers for the development of new diagnostic tools and target therapies. MDPI 2022-04-05 /pmc/articles/PMC9025914/ /pubmed/35455027 http://dx.doi.org/10.3390/life12040537 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Peracaula, Miriam Torres, Daniela Poyatos, Paula Luque, Neus Rojas, Eric Obrador, Anton Orriols, Ramon Tura-Ceide, Olga Endothelial Dysfunction and Cardiovascular Risk in Obstructive Sleep Apnea: A Review Article |
title | Endothelial Dysfunction and Cardiovascular Risk in Obstructive Sleep Apnea: A Review Article |
title_full | Endothelial Dysfunction and Cardiovascular Risk in Obstructive Sleep Apnea: A Review Article |
title_fullStr | Endothelial Dysfunction and Cardiovascular Risk in Obstructive Sleep Apnea: A Review Article |
title_full_unstemmed | Endothelial Dysfunction and Cardiovascular Risk in Obstructive Sleep Apnea: A Review Article |
title_short | Endothelial Dysfunction and Cardiovascular Risk in Obstructive Sleep Apnea: A Review Article |
title_sort | endothelial dysfunction and cardiovascular risk in obstructive sleep apnea: a review article |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025914/ https://www.ncbi.nlm.nih.gov/pubmed/35455027 http://dx.doi.org/10.3390/life12040537 |
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