Cargando…

A Computational Study of the Promiscuity of the SAM-Dependent Methyltransferase AtHTMT1

[Image: see text] A two-pronged computational approach was taken to study the promiscuity of the SAM(+)-dependent methyl transferase AtHTMT1 from thale cress with several nucleophiles (Cl(–), Br(–), I(–), NCO(–), NCS(–)). First, enzyme-free methyl transfer reactions were studied with M05/6-311+G(2d,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lankau, Timm, Ken, Hao Chun, Chang, Hsiang Ming, Yu, Chin Hui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9026064/ https://www.ncbi.nlm.nih.gov/pubmed/35474790 http://dx.doi.org/10.1021/acsomega.1c07327

Ejemplares similares

Involvement of S-adenosylmethionine-dependent halide/thiol methyltransferase (HTMT) in methyl halide emissions from agricultural plants: isolation and characterization of an HTMT-coding gene from Raphanus sativus (daikon radish)
por: Itoh, Nobuya, et al.
Publicado: (2009)

Zn(2+)-Induced Conformational Change Affects the SAM Binding in a Mycobacterial SAM-Dependent Methyltransferase
por: Majumdar, Soneya, et al.
Publicado: (2022)

Crystallographic snapshots of a B(12)-dependent radical SAM methyltransferase
por: Fyfe, Cameron D., et al.
Publicado: (2022)

Hydrogen Peroxide-Based Fluorometric Assay for Real-Time Monitoring of SAM-Dependent Methyltransferases
por: Akhtar, M. Kalim, et al.
Publicado: (2018)

Structural and functional characterization of the TYW3/Taw3 class of SAM-dependent methyltransferases
por: Currie, Mark A., et al.
Publicado: (2017)

Expression and analysis of the SAM-dependent RNA methyltransferase Rsm22 from Saccharomyces cerevisiae
por: Alam, Jahangir, et al.
Publicado: (2021)

S-Adenosylmethionine (SAM)-Dependent Methyltransferase MftM is Responsible for Methylation of the Redox Cofactor Mycofactocin
por: Ellerhorst, Mark, et al.
Publicado: (2022)

Expanding the Structural Diversity of Drimentines by Exploring the Promiscuity of Two N-methyltransferases
por: Yao, Tingting, et al.
Publicado: (2020)

Substrate Profiling of Anion Methyltransferases for Promiscuous Synthesis of S‐Adenosylmethionine Analogs from Haloalkanes
por: Schülke, Kai H., et al.
Publicado: (2022)

The conformational changes of Zika virus methyltransferase upon converting SAM to SAH
por: Zhou, Han, et al.
Publicado: (2017)

Class C Radical SAM Methyltransferases Involved in Anaerobic Heme Degradation
por: Mathew, Liju G., et al.
Publicado: (2021)

Deep Neural Network Classifier for Virtual Screening Inhibitors of (S)-Adenosyl-L-Methionine (SAM)-Dependent Methyltransferase Family
por: Li, Fei, et al.
Publicado: (2019)

Catalytic promiscuity of O-methyltransferases from Corydalis yanhusuo leading to the structural diversity of benzylisoquinoline alkaloids
por: Bu, Junling, et al.
Publicado: (2022)

Correction to “Class C Radical SAM Methyltransferases Involved in Anaerobic Heme Degradation”
por: Mathew, Liju G., et al.
Publicado: (2022)

Female Economic Dependence and the Morality of Promiscuity
por: Price, Michael E., et al.
Publicado: (2014)

Inactivation of SAM-Methyltransferase is the Mechanism of Attenuation of a Historic Louse Borne Typhus Vaccine Strain
por: Liu, Yan, et al.
Publicado: (2014)

Computational Analysis of SAM Analogs as Methyltransferase Inhibitors of nsp16/nsp10 Complex from SARS-CoV-2
por: Balieiro, Alessandra M., et al.
Publicado: (2022)

Directed Evolution of a Halide Methyltransferase Enables Biocatalytic Synthesis of Diverse SAM Analogs
por: Tang, Qingyun, et al.
Publicado: (2020)

Machine learning reveals that structural features distinguishing promiscuous and non-promiscuous compounds depend on target combinations
por: Feldmann, Christian, et al.
Publicado: (2021)

The Role of the m(6)A RNA Methyltransferase METTL16 in Gene Expression and SAM Homeostasis
por: Mermoud, Jacqueline E.
Publicado: (2022)

Structure of the Caenorhabditis elegans m(6)A methyltransferase METT10 that regulates SAM homeostasis
por: Ju, Jue, et al.
Publicado: (2023)

DØ Computing Experience and Plans for SAM-Grid
Publicado: (2003)

Promiscuous words
por: Elgar, Mark A, et al.
Publicado: (2013)

Promiscuous Ligands
por: McGovern, S.L.
Publicado: (2007)

Are PARPs promiscuous?
por: Feijs, Karla L.H., et al.
Publicado: (2022)

Computational Investigation of Structural Dynamics of SARS-CoV-2 Methyltransferase-Stimulatory Factor Heterodimer nsp16/nsp10 Bound to the Cofactor SAM
por: Sk, Md Fulbabu, et al.
Publicado: (2020)

Data structures for compound promiscuity analysis: promiscuity cliffs, pathways and promiscuity hubs formed by inhibitors of the human kinome
por: Miljković, Filip, et al.
Publicado: (2019)

Diversity of the reaction mechanisms of SAM-dependent enzymes
por: Sun, Qiu, et al.
Publicado: (2021)

Restricting Promiscuity of Plant Flavonoid 3′-Hydroxylase and 4′-O-Methyltransferase Improves the Biosynthesis of (2S)-Hesperetin in E. coli
por: Liu, Juan, et al.
Publicado: (2023)

Promiscuous drugs compared to selective drugs (promiscuity can be a virtue)
por: Mencher, Simon K, et al.
Publicado: (2005)

Sams teach yourself Windows XP computer basics
por: Perry, Greg M, et al.
Publicado: (2003)

Exploiting the promiscuity of imatinib
por: Lee, Shun J, et al.
Publicado: (2009)

Radical SAM-dependent ether crosslink in daropeptide biosynthesis
por: Guo, Sijia, et al.
Publicado: (2022)

Insights into the structure, function and evolution of the radical-SAM 23S rRNA methyltransferase Cfr that confers antibiotic resistance in bacteria
por: Kaminska, Katarzyna H., et al.
Publicado: (2010)

Potent SARS-CoV-2 mRNA Cap Methyltransferase Inhibitors by Bioisosteric Replacement of Methionine in SAM Cosubstrate
por: Bobiļeva, Olga, et al.
Publicado: (2021)

MULTIPRED: a computational system for prediction of promiscuous HLA binding peptides
por: Zhang, Guang Lan, et al.
Publicado: (2005)

Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum
por: Wang, Jigang, et al.
Publicado: (2015)

Crystallographic and Computational Characterization of Methyl Tetrel Bonding in S-Adenosylmethionine-Dependent Methyltransferases
por: Trievel, Raymond C., et al.
Publicado: (2018)

Achieving Peptide Binding Specificity and Promiscuity by Loops: Case of the Forkhead-Associated Domain
por: Huang, Yu-ming M., et al.
Publicado: (2014)

Sam Peckinpah /
por: Urkijo, Francisco Javier
Publicado: (1995)

Cannot write session to /tmp/vufind_sessions/sess_5ppv4omkiiupbfdcc4kbimnmi8