Cargando…

Madecassic Acid—A New Scaffold for Highly Cytotoxic Agents

Due to their manifold biological activities, natural products such as triterpenoids have advanced to represent excellent leading structures for the development of new drugs. For this reason, we focused on the syntheses and cytotoxic evaluation of derivatives obtained from gypsogenin, hederagenin, an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kraft, Oliver, Hartmann, Ann-Kathrin, Hoenke, Sophie, Serbian, Immo, Csuk, René
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9026082/ https://www.ncbi.nlm.nih.gov/pubmed/35457180 http://dx.doi.org/10.3390/ijms23084362

Ejemplares similares

Rhodamine 101 Conjugates of Triterpenoic Amides Are of Comparable Cytotoxicity as Their Rhodamine B Analogs
por: Heise, Niels V., et al.
Publicado: (2022)

Mitocanic Di- and Triterpenoid Rhodamine B Conjugates
por: Hoenke, Sophie, et al.
Publicado: (2020)

An Improved Scalable Synthesis of α- and β-Amyrin
por: Serbian, Immo, et al.
Publicado: (2018)

Small Structural Differences Govern the Carbonic Anhydrase II Inhibition Activity of Cytotoxic Triterpene Acetazolamide Conjugates
por: Denner, Toni C., et al.
Publicado: (2023)

Synthesis and Cytotoxicity Evaluation of DOTA-Conjugates of Ursolic Acid
por: Kahnt, Michael, et al.
Publicado: (2019)

In the Mists of a Fungal Metabolite: An Unexpected Reaction of 2,4,5-Trimethoxyphenylglyoxylic Acid
por: Serbian, Immo, et al.
Publicado: (2020)

Synthesis and In Silico Docking of New Pyrazolo[4,3-e]pyrido[1,2-a]pyrimidine-based Cytotoxic Agents
por: Horchani, Mabrouk, et al.
Publicado: (2021)

The Finally Rewarding Search for A Cytotoxic Isosteviol Derivative
por: Heisig, Julia, et al.
Publicado: (2023)

Anti-Diabetic Effects of Madecassic Acid and Rotundic Acid
por: Hsu, Yuan-Man, et al.
Publicado: (2015)

Triterpene-Based Carboxamides Act as Good Inhibitors of Butyrylcholinesterase
por: Loesche, Anne, et al.
Publicado: (2019)

n-Propyl 6-amino-2,6-dideoxy-2,2-difluoro-β-d-glucopyranoside is a good inhibitor for the β-galactosidase from E. coli
por: Serbian, Immo, et al.
Publicado: (2021)

Cytotoxic Potential of a-Azepano- and 3-Amino-3,4-SeCo-Triterpenoids
por: Kazakova, Oxana, et al.
Publicado: (2021)

Developing an Amide-Spacered Triterpenoid Rhodamine Hybrid of Nano-Molar Cytotoxicity Combined with Excellent Tumor Cell/Non-Tumor Cell Selectivity
por: Heise, Niels V., et al.
Publicado: (2023)

Antibacterial Activity and Mechanism of Madecassic Acid against Staphylococcus aureus
por: Wei, Chunling, et al.
Publicado: (2023)

Madecassic Acid Ameliorates the Progression of Osteoarthritis: An in vitro and in vivo Study
por: Fu, Xuejie, et al.
Publicado: (2022)

Synthesis and Biological Evaluation of New Madecassic Acid Derivatives Targeting ERK Cascade Signaling
por: Valdeira, Ana S. C., et al.
Publicado: (2018)

The Presence of a Cyclohexyldiamine Moiety Confers Cytotoxicity to Pentacyclic Triterpenoids
por: Hoenke, Sophie, et al.
Publicado: (2021)

Engineering of Yarrowia lipolytica for the production of plant triterpenoids: Asiatic, madecassic, and arjunolic acids
por: Arnesen, Jonathan Asmund, et al.
Publicado: (2022)

Ethylenediamine Derived Carboxamides of Betulinic and Ursolic Acid as Potential Cytotoxic Agents
por: Kahnt, Michael, et al.
Publicado: (2018)

Self-Nanoemulsifying Drug Delivery System for Enhanced Bioavailability of Madecassic Acid: In vitro and in vivo Evaluation
por: Lin, Li, et al.
Publicado: (2023)

Synthesis and Biological Evaluation of Structurally Varied 5′-/6′-Isonucleosides and Theobromine-Containing N-Isonucleosidyl Derivatives
por: Xavier, Nuno M., et al.
Publicado: (2019)

Structural Analysis of Metabolites of Asiatic Acid and Its Analogue Madecassic Acid in Zebrafish Using LC/IT-MS(n)
por: Xia, Binbin, et al.
Publicado: (2015)

Beneficial effects of murtilla extract and madecassic acid on insulin sensitivity and endothelial function in a model of diet-induced obesity
por: Arancibia-Radich, Jorge, et al.
Publicado: (2019)

Racemization-free synthesis of Nα-2-thiophenoyl-phenylalanine-2-morpholinoanilide enantiomers and their antimycobacterial activity
por: Mann, Lea, et al.
Publicado: (2021)

Madecassic acid, the contributor to the anti-colitis effect of madecassoside, enhances the shift of Th17 toward Treg cells via the PPARγ/AMPK/ACC1 pathway
por: Xu, Xiaotian, et al.
Publicado: (2017)

Inhibition of the activation of γδT17 cells through PPARγ–PTEN/Akt/GSK3β/NFAT pathway contributes to the anti-colitis effect of madecassic acid
por: Yun, Xinming, et al.
Publicado: (2020)

Amino Acid Derivatives of Ligustrazine-Oleanolic Acid as New Cytotoxic Agents
por: Chu, Fuhao, et al.
Publicado: (2014)

In Vitro Evaluation of the Antimicrobial Ability and Cytotoxicity on Two Melanoma Cell Lines of a Benzylamide Derivative of Maslinic Acid
por: Pavel, Ioana Zinuca, et al.
Publicado: (2016)

Searching for new cytotoxic agents based on chromen-4-one and chromane-2,4-dione scaffolds
por: Gaspar, Alexandra, et al.
Publicado: (2019)

Comparative study of the cytotoxicity, apoptotic, and epigenetic effects of Boswellic acid derivatives on breast cancer
por: Jamshidi-adegani, Fatemeh, et al.
Publicado: (2022)

Mitochondria-Targeting 1,5-Diazacyclooctane-Spacered Triterpene Rhodamine Conjugates Exhibit Cytotoxicity at Sub-Nanomolar Concentration against Breast Cancer Cells
por: Heise, Niels, et al.
Publicado: (2023)

Diterpenoids and Triterpenoids From Frankincense Are Excellent Anti-psoriatic Agents: An in silico Approach
por: Halim, Sobia Ahsan, et al.
Publicado: (2020)

An Understanding of Mechanism-Based Approaches for 1,3,4-Oxadiazole Scaffolds as Cytotoxic Agents and Enzyme Inhibitors
por: Kumar, Davinder, et al.
Publicado: (2023)

New pyridine and chromene scaffolds as potent vasorelaxant and anticancer agents
por: Dawood, Dina H., et al.
Publicado: (2021)

Challenges in Bone Tissue Regeneration: Stem Cell Therapy, Biofunctionality and Antimicrobial Properties of Novel Materials and Its Evolution
por: Riester, Oliver, et al.
Publicado: (2020)

Dimeric MHC-peptides inserted into an immunoglobulin scaffold as new immunotherapeutic agents
por: Goldberg, Burt, et al.
Publicado: (2011)

Synthesis of hydroxycinnamic acid derivatives as mitochondria-targeted antioxidants and cytotoxic agents
por: Li, Jiyu, et al.
Publicado: (2017)

Synthesis and bioactivity evaluation of pachymic acid derivatives as potential cytotoxic agents
por: Wang, Hezhen, et al.
Publicado: (2022)

COVID-19/SARS-CoV-2 Infection: Lysosomes and Lysosomotropism Implicate New Treatment Strategies and Personal Risks
por: Blaess, Markus, et al.
Publicado: (2020)

Drugs, Metabolites, and Lung Accumulating Small Lysosomotropic Molecules: Multiple Targeting Impedes SARS-CoV-2 Infection and Progress to COVID-19
por: Blaess, Markus, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_41bfg7o0uvstcu4k5aplngtmar