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Computational Analysis of the Inhibition Mechanism of NOTUM by the ONIOM Method
[Image: see text] Notum is a member of serine hydrolyses that cleaves the palmitoleate moiety from Wingless-related integration site (Wnt) ligands. This enzyme plays crucial functions through modulating the Wnt signaling pathway. Inhibition of Notum carries therapeutic effects against a number of ma...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9026088/ https://www.ncbi.nlm.nih.gov/pubmed/35474786 http://dx.doi.org/10.1021/acsomega.2c01044 |