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Novel directions of precision oncology: circulating microbial DNA emerging in cancer-microbiome areas

Microbiome research has extended into the cancer area in the past decades. Microbes can affect oncogenesis, progression, and treatment response through various mechanisms, including direct regulation and indirect impacts. Microbiota-associated detection methods and agents have been developed to faci...

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Autores principales: You, Liting, Zhou, Juan, Xin, Zhaodan, Hauck, J Spencer, Na, Feifei, Tang, Jie, Zhou, Xiaohan, Lei, Zichen, Ying, Binwu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9026200/
https://www.ncbi.nlm.nih.gov/pubmed/35692444
http://dx.doi.org/10.1093/pcmedi/pbac005
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author You, Liting
Zhou, Juan
Xin, Zhaodan
Hauck, J Spencer
Na, Feifei
Tang, Jie
Zhou, Xiaohan
Lei, Zichen
Ying, Binwu
author_facet You, Liting
Zhou, Juan
Xin, Zhaodan
Hauck, J Spencer
Na, Feifei
Tang, Jie
Zhou, Xiaohan
Lei, Zichen
Ying, Binwu
author_sort You, Liting
collection PubMed
description Microbiome research has extended into the cancer area in the past decades. Microbes can affect oncogenesis, progression, and treatment response through various mechanisms, including direct regulation and indirect impacts. Microbiota-associated detection methods and agents have been developed to facilitate cancer diagnosis and therapy. Additionally, the cancer microbiome has recently been redefined. The identification of intra-tumoral microbes and cancer-related circulating microbial DNA (cmDNA) has promoted novel research in the cancer–microbiome area. In this review, we define the human system of commensal microbes and the cancer microbiome from a brand-new perspective and emphasize the potential value of cmDNA as a promising biomarker in cancer liquid biopsy. We outline all existing studies on the relationship between cmDNA and cancer and the outlook for potential preclinical and clinical applications of cmDNA in cancer precision medicine, as well as critical problems to be overcome in this burgeoning field.
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spelling pubmed-90262002022-06-10 Novel directions of precision oncology: circulating microbial DNA emerging in cancer-microbiome areas You, Liting Zhou, Juan Xin, Zhaodan Hauck, J Spencer Na, Feifei Tang, Jie Zhou, Xiaohan Lei, Zichen Ying, Binwu Precis Clin Med Review Microbiome research has extended into the cancer area in the past decades. Microbes can affect oncogenesis, progression, and treatment response through various mechanisms, including direct regulation and indirect impacts. Microbiota-associated detection methods and agents have been developed to facilitate cancer diagnosis and therapy. Additionally, the cancer microbiome has recently been redefined. The identification of intra-tumoral microbes and cancer-related circulating microbial DNA (cmDNA) has promoted novel research in the cancer–microbiome area. In this review, we define the human system of commensal microbes and the cancer microbiome from a brand-new perspective and emphasize the potential value of cmDNA as a promising biomarker in cancer liquid biopsy. We outline all existing studies on the relationship between cmDNA and cancer and the outlook for potential preclinical and clinical applications of cmDNA in cancer precision medicine, as well as critical problems to be overcome in this burgeoning field. Oxford University Press 2022-02-03 /pmc/articles/PMC9026200/ /pubmed/35692444 http://dx.doi.org/10.1093/pcmedi/pbac005 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of the West China School of Medicine & West China Hospital of Sichuan University. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
You, Liting
Zhou, Juan
Xin, Zhaodan
Hauck, J Spencer
Na, Feifei
Tang, Jie
Zhou, Xiaohan
Lei, Zichen
Ying, Binwu
Novel directions of precision oncology: circulating microbial DNA emerging in cancer-microbiome areas
title Novel directions of precision oncology: circulating microbial DNA emerging in cancer-microbiome areas
title_full Novel directions of precision oncology: circulating microbial DNA emerging in cancer-microbiome areas
title_fullStr Novel directions of precision oncology: circulating microbial DNA emerging in cancer-microbiome areas
title_full_unstemmed Novel directions of precision oncology: circulating microbial DNA emerging in cancer-microbiome areas
title_short Novel directions of precision oncology: circulating microbial DNA emerging in cancer-microbiome areas
title_sort novel directions of precision oncology: circulating microbial dna emerging in cancer-microbiome areas
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9026200/
https://www.ncbi.nlm.nih.gov/pubmed/35692444
http://dx.doi.org/10.1093/pcmedi/pbac005
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