GET pathway mediates transfer of mislocalized tail-anchored proteins from mitochondria to the ER

Tail-anchored (TA) membrane proteins have a potential risk to be mistargeted to the mitochondrial outer membrane (OM). Such mislocalized TA proteins can be extracted by the mitochondrial AAA-ATPase Msp1 from the OM and transferred to the ER for ER protein quality control involving ubiquitination by...

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Detalles Bibliográficos
Autores principales: Matsumoto, Shunsuke, Ono, Suzuka, Shinoda, Saori, Kakuta, Chika, Okada, Satoshi, Ito, Takashi, Numata, Tomoyuki, Endo, Toshiya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9026240/
https://www.ncbi.nlm.nih.gov/pubmed/35442388
http://dx.doi.org/10.1083/jcb.202104076

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