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Surface Requirements for Optimal Biosensing with Disposable Gold Electrodes
[Image: see text] Electrochemical biosensors are promising technologies for detection and monitoring in low-resource settings due to their potential for easy use and low-cost instrumentation. Disposable gold screen-printed electrodes (SPEs) are popular substrates for these biosensors, but necessary...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9026247/ https://www.ncbi.nlm.nih.gov/pubmed/35479101 http://dx.doi.org/10.1021/acsmeasuresciau.1c00042 |
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author | Zamani, Marjon Yang, Victoria Maziashvili, Lizi Fan, Gang Klapperich, Catherine M. Furst, Ariel L. |
author_facet | Zamani, Marjon Yang, Victoria Maziashvili, Lizi Fan, Gang Klapperich, Catherine M. Furst, Ariel L. |
author_sort | Zamani, Marjon |
collection | PubMed |
description | [Image: see text] Electrochemical biosensors are promising technologies for detection and monitoring in low-resource settings due to their potential for easy use and low-cost instrumentation. Disposable gold screen-printed electrodes (SPEs) are popular substrates for these biosensors, but necessary dopants in the ink used for their production can interfere with biosensor function and contribute to the heterogeneity of these electrodes. We recently reported an alternative disposable gold electrode made from gold leaf generated using low-cost, equipment-free fabrication. We have directly compared the surface topology, biorecognition element deposition, and functional performance of three disposable gold electrodes: our gold leaf electrodes and two commercial SPEs. Our leaf electrodes significantly outperformed the SPEs for reproducible and effective biosensing in a DNase I assay and are nearly an order of magnitude less expensive than the SPEs. Therefore, these electrodes are promising for further development as point-of-care diagnostics, especially in low-resource settings. |
format | Online Article Text |
id | pubmed-9026247 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-90262472022-04-25 Surface Requirements for Optimal Biosensing with Disposable Gold Electrodes Zamani, Marjon Yang, Victoria Maziashvili, Lizi Fan, Gang Klapperich, Catherine M. Furst, Ariel L. ACS Meas Sci Au [Image: see text] Electrochemical biosensors are promising technologies for detection and monitoring in low-resource settings due to their potential for easy use and low-cost instrumentation. Disposable gold screen-printed electrodes (SPEs) are popular substrates for these biosensors, but necessary dopants in the ink used for their production can interfere with biosensor function and contribute to the heterogeneity of these electrodes. We recently reported an alternative disposable gold electrode made from gold leaf generated using low-cost, equipment-free fabrication. We have directly compared the surface topology, biorecognition element deposition, and functional performance of three disposable gold electrodes: our gold leaf electrodes and two commercial SPEs. Our leaf electrodes significantly outperformed the SPEs for reproducible and effective biosensing in a DNase I assay and are nearly an order of magnitude less expensive than the SPEs. Therefore, these electrodes are promising for further development as point-of-care diagnostics, especially in low-resource settings. American Chemical Society 2021-11-12 /pmc/articles/PMC9026247/ /pubmed/35479101 http://dx.doi.org/10.1021/acsmeasuresciau.1c00042 Text en © 2021 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Zamani, Marjon Yang, Victoria Maziashvili, Lizi Fan, Gang Klapperich, Catherine M. Furst, Ariel L. Surface Requirements for Optimal Biosensing with Disposable Gold Electrodes |
title | Surface Requirements for Optimal Biosensing with Disposable
Gold Electrodes |
title_full | Surface Requirements for Optimal Biosensing with Disposable
Gold Electrodes |
title_fullStr | Surface Requirements for Optimal Biosensing with Disposable
Gold Electrodes |
title_full_unstemmed | Surface Requirements for Optimal Biosensing with Disposable
Gold Electrodes |
title_short | Surface Requirements for Optimal Biosensing with Disposable
Gold Electrodes |
title_sort | surface requirements for optimal biosensing with disposable
gold electrodes |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9026247/ https://www.ncbi.nlm.nih.gov/pubmed/35479101 http://dx.doi.org/10.1021/acsmeasuresciau.1c00042 |
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