Life-threatening viral disease in a novel form of autosomal recessive IFNAR2 deficiency in the Arctic

Type I interferons (IFN-I) play a critical role in human antiviral immunity, as demonstrated by the exceptionally rare deleterious variants of IFNAR1 or IFNAR2. We investigated five children from Greenland, Canada, and Alaska presenting with viral diseases, including life-threatening COVID-19 or inf...

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Detalles Bibliográficos
Autores principales: Duncan, Christopher J.A., Skouboe, Morten K., Howarth, Sophie, Hollensen, Anne K., Chen, Rui, Børresen, Malene L., Thompson, Benjamin J., Stremenova Spegarova, Jarmila, Hatton, Catherine F., Stæger, Frederik F., Andersen, Mette K., Whittaker, John, Paludan, Søren R., Jørgensen, Sofie E., Thomsen, Martin K., Mikkelsen, Jacob G., Heilmann, Carsten, Buhas, Daniela, Øbro, Nina F., Bay, Jakob T., Marquart, Hanne V., de la Morena, M. Teresa, Klejka, Joseph A., Hirschfeld, Matthew, Borgwardt, Line, Forss, Isabel, Masmas, Tania, Poulsen, Anja, Noya, Francisco, Rouleau, Guy, Hansen, Torben, Zhou, Sirui, Albrechtsen, Anders, Alizadehfar, Reza, Allenspach, Eric J., Hambleton, Sophie, Mogensen, Trine H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9026249/
https://www.ncbi.nlm.nih.gov/pubmed/35442417
http://dx.doi.org/10.1084/jem.20212427

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