Impact of Drug Conjugation on Thermal and Metabolic Stabilities of Aglycosylated and N-Glycosylated Antibodies

[Image: see text] N-linked glycosylation is one of the most common and complex posttranslational modifications that govern the biological functions and physicochemical properties of therapeutic antibodies. We evaluated thermal and metabolic stabilities of antibody–drug conjugates (ADCs) with payload...

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Detalles Bibliográficos
Autores principales: Yamazoe, Sayumi, Kotapati, Srikanth, Hogan, Jason M., West, Sean M., Deng, Xiaodi A., Diong, SJ, Arbanas, Jaren, Nguyen, Thien Anh, Jashnani, Aarti, Gupta, Diksha, Rajpal, Arvind, Dollinger, Gavin, Strop, Pavel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9026278/
https://www.ncbi.nlm.nih.gov/pubmed/35344340
http://dx.doi.org/10.1021/acs.bioconjchem.1c00572

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