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Dissecting Fc signatures of protection in neonates following maternal influenza vaccination in a placebo-controlled trial
Influenza is an important cause of illness and morbidity for infants. Seasonal influenza vaccination during pregnancy aims to provide protection to mothers, but it can also provide immunity to infants. The precise influence of maternal vaccination on immunity in infants and how vaccine-elicited anti...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9026287/ https://www.ncbi.nlm.nih.gov/pubmed/35139373 http://dx.doi.org/10.1016/j.celrep.2022.110337 |
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author | Boudreau, Carolyn M. Burke, John S. Shuey, Kiel D. Wolf, Caitlin Katz, Joanne Tielsch, James Khatry, Subarna LeClerq, Steven C. Englund, Janet A. Chu, Helen Y. Alter, Galit |
author_facet | Boudreau, Carolyn M. Burke, John S. Shuey, Kiel D. Wolf, Caitlin Katz, Joanne Tielsch, James Khatry, Subarna LeClerq, Steven C. Englund, Janet A. Chu, Helen Y. Alter, Galit |
author_sort | Boudreau, Carolyn M. |
collection | PubMed |
description | Influenza is an important cause of illness and morbidity for infants. Seasonal influenza vaccination during pregnancy aims to provide protection to mothers, but it can also provide immunity to infants. The precise influence of maternal vaccination on immunity in infants and how vaccine-elicited antibodies provide protection in some but not all infants is incompletely understood. We comprehensively profiled the transfer of functional antibodies and defined humoral factors contributing to immunity against influenza in a clinical trial of maternal influenza vaccination. Influenza-specific antibody subclass levels, Fc ɣ receptor (FCGR) binding levels, and antibody-dependent innate immune functions were all profiled in the mothers during pregnancy and at birth, as well as in cord blood. Vaccination increased influenza-specific antibody levels, antibody binding to FCGR, and specific antibody-dependent innate immune functions in both maternal and cord blood, with FCGR binding most enhanced via vaccination. Influenza-specific FCGR binding levels were lower in cord blood of infants who subsequently developed influenza infection. Collectively these data suggest that in addition to increased antibody amounts, the selective transfer of FCGR-binding antibodies contributes to the protective immune response in infants against influenza. |
format | Online Article Text |
id | pubmed-9026287 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Cell Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-90262872022-05-24 Dissecting Fc signatures of protection in neonates following maternal influenza vaccination in a placebo-controlled trial Boudreau, Carolyn M. Burke, John S. Shuey, Kiel D. Wolf, Caitlin Katz, Joanne Tielsch, James Khatry, Subarna LeClerq, Steven C. Englund, Janet A. Chu, Helen Y. Alter, Galit Cell Rep Article Influenza is an important cause of illness and morbidity for infants. Seasonal influenza vaccination during pregnancy aims to provide protection to mothers, but it can also provide immunity to infants. The precise influence of maternal vaccination on immunity in infants and how vaccine-elicited antibodies provide protection in some but not all infants is incompletely understood. We comprehensively profiled the transfer of functional antibodies and defined humoral factors contributing to immunity against influenza in a clinical trial of maternal influenza vaccination. Influenza-specific antibody subclass levels, Fc ɣ receptor (FCGR) binding levels, and antibody-dependent innate immune functions were all profiled in the mothers during pregnancy and at birth, as well as in cord blood. Vaccination increased influenza-specific antibody levels, antibody binding to FCGR, and specific antibody-dependent innate immune functions in both maternal and cord blood, with FCGR binding most enhanced via vaccination. Influenza-specific FCGR binding levels were lower in cord blood of infants who subsequently developed influenza infection. Collectively these data suggest that in addition to increased antibody amounts, the selective transfer of FCGR-binding antibodies contributes to the protective immune response in infants against influenza. Cell Press 2022-02-08 /pmc/articles/PMC9026287/ /pubmed/35139373 http://dx.doi.org/10.1016/j.celrep.2022.110337 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Boudreau, Carolyn M. Burke, John S. Shuey, Kiel D. Wolf, Caitlin Katz, Joanne Tielsch, James Khatry, Subarna LeClerq, Steven C. Englund, Janet A. Chu, Helen Y. Alter, Galit Dissecting Fc signatures of protection in neonates following maternal influenza vaccination in a placebo-controlled trial |
title | Dissecting Fc signatures of protection in neonates following maternal influenza vaccination in a placebo-controlled trial |
title_full | Dissecting Fc signatures of protection in neonates following maternal influenza vaccination in a placebo-controlled trial |
title_fullStr | Dissecting Fc signatures of protection in neonates following maternal influenza vaccination in a placebo-controlled trial |
title_full_unstemmed | Dissecting Fc signatures of protection in neonates following maternal influenza vaccination in a placebo-controlled trial |
title_short | Dissecting Fc signatures of protection in neonates following maternal influenza vaccination in a placebo-controlled trial |
title_sort | dissecting fc signatures of protection in neonates following maternal influenza vaccination in a placebo-controlled trial |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9026287/ https://www.ncbi.nlm.nih.gov/pubmed/35139373 http://dx.doi.org/10.1016/j.celrep.2022.110337 |
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