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The Expanding Role of the Infectious Disease Expert in the Context of the MS Centre

Introduction: The complexity of the MS patient’s management is constantly growing. Consequently, the MS care unit requires a multidisciplinary approach, including an infectious disease specialist to minimise the risk of infectious complications related both to the disease and DMTs. Materials and met...

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Autores principales: Lucchini, Matteo, Del Giacomo, Paola, De Arcangelis, Valeria, Nociti, Viviana, Bianco, Assunta, De Fino, Chiara, Presicce, Giorgia, Cicia, Alessandra, Carlomagno, Vincenzo, Mirabella, Massimiliano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9026290/
https://www.ncbi.nlm.nih.gov/pubmed/35455707
http://dx.doi.org/10.3390/jpm12040591
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author Lucchini, Matteo
Del Giacomo, Paola
De Arcangelis, Valeria
Nociti, Viviana
Bianco, Assunta
De Fino, Chiara
Presicce, Giorgia
Cicia, Alessandra
Carlomagno, Vincenzo
Mirabella, Massimiliano
author_facet Lucchini, Matteo
Del Giacomo, Paola
De Arcangelis, Valeria
Nociti, Viviana
Bianco, Assunta
De Fino, Chiara
Presicce, Giorgia
Cicia, Alessandra
Carlomagno, Vincenzo
Mirabella, Massimiliano
author_sort Lucchini, Matteo
collection PubMed
description Introduction: The complexity of the MS patient’s management is constantly growing. Consequently, the MS care unit requires a multidisciplinary approach, including an infectious disease specialist to minimise the risk of infectious complications related both to the disease and DMTs. Materials and methods: We retrospectively evaluated the infectious disease consultations performed from 2015 to 2019 in our MS centre. Results: We identified 107 patients with at least one infectious disease consultation out of 1088 patients. We found a progressive increase in the number of consultations from 2015 to 2019. Nearly half of the consultations were requested at the time of starting MS treatment. The most frequent requests were represented by chronic or acute infections. The most prevalent infectious agents were Herpesviridae and Mycobacterium tuberculosis. Antibiotic or antiviral treatment and prophylactic treatment or vaccination represented together the most frequent outcomes of the consultations. Finally, a treatment delay was significantly associated with the advice of a prophylactic treatment or of a vaccination. Conclusion: There is an increasing awareness of the potential infectious complications of MS and of exposure to DMTs. The interaction between the MS neurologist and infectious disease specialist is fundamental to minimise the infectious risk related to the disease and to the DMTs, with a progressive shift from complication management to a broader prevention workup at the time of MS diagnosis, including both vaccination and prophylactic treatments.
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spelling pubmed-90262902022-04-23 The Expanding Role of the Infectious Disease Expert in the Context of the MS Centre Lucchini, Matteo Del Giacomo, Paola De Arcangelis, Valeria Nociti, Viviana Bianco, Assunta De Fino, Chiara Presicce, Giorgia Cicia, Alessandra Carlomagno, Vincenzo Mirabella, Massimiliano J Pers Med Article Introduction: The complexity of the MS patient’s management is constantly growing. Consequently, the MS care unit requires a multidisciplinary approach, including an infectious disease specialist to minimise the risk of infectious complications related both to the disease and DMTs. Materials and methods: We retrospectively evaluated the infectious disease consultations performed from 2015 to 2019 in our MS centre. Results: We identified 107 patients with at least one infectious disease consultation out of 1088 patients. We found a progressive increase in the number of consultations from 2015 to 2019. Nearly half of the consultations were requested at the time of starting MS treatment. The most frequent requests were represented by chronic or acute infections. The most prevalent infectious agents were Herpesviridae and Mycobacterium tuberculosis. Antibiotic or antiviral treatment and prophylactic treatment or vaccination represented together the most frequent outcomes of the consultations. Finally, a treatment delay was significantly associated with the advice of a prophylactic treatment or of a vaccination. Conclusion: There is an increasing awareness of the potential infectious complications of MS and of exposure to DMTs. The interaction between the MS neurologist and infectious disease specialist is fundamental to minimise the infectious risk related to the disease and to the DMTs, with a progressive shift from complication management to a broader prevention workup at the time of MS diagnosis, including both vaccination and prophylactic treatments. MDPI 2022-04-07 /pmc/articles/PMC9026290/ /pubmed/35455707 http://dx.doi.org/10.3390/jpm12040591 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lucchini, Matteo
Del Giacomo, Paola
De Arcangelis, Valeria
Nociti, Viviana
Bianco, Assunta
De Fino, Chiara
Presicce, Giorgia
Cicia, Alessandra
Carlomagno, Vincenzo
Mirabella, Massimiliano
The Expanding Role of the Infectious Disease Expert in the Context of the MS Centre
title The Expanding Role of the Infectious Disease Expert in the Context of the MS Centre
title_full The Expanding Role of the Infectious Disease Expert in the Context of the MS Centre
title_fullStr The Expanding Role of the Infectious Disease Expert in the Context of the MS Centre
title_full_unstemmed The Expanding Role of the Infectious Disease Expert in the Context of the MS Centre
title_short The Expanding Role of the Infectious Disease Expert in the Context of the MS Centre
title_sort expanding role of the infectious disease expert in the context of the ms centre
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9026290/
https://www.ncbi.nlm.nih.gov/pubmed/35455707
http://dx.doi.org/10.3390/jpm12040591
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