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Staphylococcus schweitzeri—An Emerging One Health Pathogen?

The Staphylococcus aureus-related complex is formed by the Staphylococcus aureus, Staphylococcus schweitzeri, Staphylococcus argenteus, Staphylococcus roterodami and Staphylococcus singaporensis. Within this complex, S. schweitzeri is the only species mainly found in African wildlife, but it is rare...

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Autores principales: Akoua-Koffi, Chantal, Kacou N’Douba, Adèle, Djaman, Joseph Allico, Herrmann, Mathias, Schaumburg, Frieder, Niemann, Silke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9026344/
https://www.ncbi.nlm.nih.gov/pubmed/35456820
http://dx.doi.org/10.3390/microorganisms10040770
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author Akoua-Koffi, Chantal
Kacou N’Douba, Adèle
Djaman, Joseph Allico
Herrmann, Mathias
Schaumburg, Frieder
Niemann, Silke
author_facet Akoua-Koffi, Chantal
Kacou N’Douba, Adèle
Djaman, Joseph Allico
Herrmann, Mathias
Schaumburg, Frieder
Niemann, Silke
author_sort Akoua-Koffi, Chantal
collection PubMed
description The Staphylococcus aureus-related complex is formed by the Staphylococcus aureus, Staphylococcus schweitzeri, Staphylococcus argenteus, Staphylococcus roterodami and Staphylococcus singaporensis. Within this complex, S. schweitzeri is the only species mainly found in African wildlife, but it is rarely detected as a colonizer in humans or as a contaminant of fomites. The few detections in humans are most likely spillover events after contact with wildlife. However, since S. schweitzeri can be misidentified as S. aureus using culture-based routine techniques, it is likely that S. schweitzeri is under-reported in humans. The low number of isolates in humans, though, is consistent with the fact that the pathogen has typical animal adaptation characteristics (e.g., growth kinetics, lack of immune evasion cluster and antimicrobial resistance); however, evidence from selected in vitro assays (e.g., host cell invasion, cell activation, cytotoxicity) indicate that S. schweitzeri might be as virulent as S. aureus. In this case, contact with animals colonized with S. schweitzeri could constitute a risk for zoonotic infections. With respect to antimicrobial resistance, all described isolates were found to be susceptible to all antibiotics tested, and so far no data on the development of spontaneous resistance or the acquisition of resistance genes such the mecA/mecC cassette are available. In summary, general knowledge about this pathogen, specifically on the potential threat it may incur to human and animal health, is still very poor. In this review article, we compile the present state of scientific research, and identify the knowledge gaps that need to be filled in order to reliably assess S. schweitzeri as an organism with global One Health implications.
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spelling pubmed-90263442022-04-23 Staphylococcus schweitzeri—An Emerging One Health Pathogen? Akoua-Koffi, Chantal Kacou N’Douba, Adèle Djaman, Joseph Allico Herrmann, Mathias Schaumburg, Frieder Niemann, Silke Microorganisms Review The Staphylococcus aureus-related complex is formed by the Staphylococcus aureus, Staphylococcus schweitzeri, Staphylococcus argenteus, Staphylococcus roterodami and Staphylococcus singaporensis. Within this complex, S. schweitzeri is the only species mainly found in African wildlife, but it is rarely detected as a colonizer in humans or as a contaminant of fomites. The few detections in humans are most likely spillover events after contact with wildlife. However, since S. schweitzeri can be misidentified as S. aureus using culture-based routine techniques, it is likely that S. schweitzeri is under-reported in humans. The low number of isolates in humans, though, is consistent with the fact that the pathogen has typical animal adaptation characteristics (e.g., growth kinetics, lack of immune evasion cluster and antimicrobial resistance); however, evidence from selected in vitro assays (e.g., host cell invasion, cell activation, cytotoxicity) indicate that S. schweitzeri might be as virulent as S. aureus. In this case, contact with animals colonized with S. schweitzeri could constitute a risk for zoonotic infections. With respect to antimicrobial resistance, all described isolates were found to be susceptible to all antibiotics tested, and so far no data on the development of spontaneous resistance or the acquisition of resistance genes such the mecA/mecC cassette are available. In summary, general knowledge about this pathogen, specifically on the potential threat it may incur to human and animal health, is still very poor. In this review article, we compile the present state of scientific research, and identify the knowledge gaps that need to be filled in order to reliably assess S. schweitzeri as an organism with global One Health implications. MDPI 2022-04-02 /pmc/articles/PMC9026344/ /pubmed/35456820 http://dx.doi.org/10.3390/microorganisms10040770 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Akoua-Koffi, Chantal
Kacou N’Douba, Adèle
Djaman, Joseph Allico
Herrmann, Mathias
Schaumburg, Frieder
Niemann, Silke
Staphylococcus schweitzeri—An Emerging One Health Pathogen?
title Staphylococcus schweitzeri—An Emerging One Health Pathogen?
title_full Staphylococcus schweitzeri—An Emerging One Health Pathogen?
title_fullStr Staphylococcus schweitzeri—An Emerging One Health Pathogen?
title_full_unstemmed Staphylococcus schweitzeri—An Emerging One Health Pathogen?
title_short Staphylococcus schweitzeri—An Emerging One Health Pathogen?
title_sort staphylococcus schweitzeri—an emerging one health pathogen?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9026344/
https://www.ncbi.nlm.nih.gov/pubmed/35456820
http://dx.doi.org/10.3390/microorganisms10040770
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