Intestinal Alkaline Phosphatase: A Review of This Enzyme Role in the Intestinal Barrier Function

Intestinal alkaline phosphatase (IALP) has recently assumed a special relevance, being the subject of study in the prevention and treatment of certain diseases related to leaky gut. This brush border enzyme (ecto-enzyme) plays an important role in the maintenance of intestinal microbial homeostasis...

Descripción completa

Detalles Bibliográficos
Autores principales: Santos, Gilberto Maia, Ismael, Shámila, Morais, Juliana, Araújo, João R., Faria, Ana, Calhau, Conceição, Marques, Cláudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9026380/
https://www.ncbi.nlm.nih.gov/pubmed/35456797
http://dx.doi.org/10.3390/microorganisms10040746
_version_ 1784691106539110400
author Santos, Gilberto Maia
Ismael, Shámila
Morais, Juliana
Araújo, João R.
Faria, Ana
Calhau, Conceição
Marques, Cláudia
author_facet Santos, Gilberto Maia
Ismael, Shámila
Morais, Juliana
Araújo, João R.
Faria, Ana
Calhau, Conceição
Marques, Cláudia
author_sort Santos, Gilberto Maia
collection PubMed
description Intestinal alkaline phosphatase (IALP) has recently assumed a special relevance, being the subject of study in the prevention and treatment of certain diseases related to leaky gut. This brush border enzyme (ecto-enzyme) plays an important role in the maintenance of intestinal microbial homeostasis and intestinal barrier function through its ability to dephosphorylate lipopolysaccharide (LPS). This review addresses how IALP and intestinal barrier dysfunction may be implicated in the pathophysiology of specific diseases such as inflammatory bowel disease, necrotizing enterocolitis, and metabolic syndrome. The use of IALP as a possible biomarker to assess intestinal barrier function and strategies to modulate IALP activity are also discussed.
format Online
Article
Text
id pubmed-9026380
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-90263802022-04-23 Intestinal Alkaline Phosphatase: A Review of This Enzyme Role in the Intestinal Barrier Function Santos, Gilberto Maia Ismael, Shámila Morais, Juliana Araújo, João R. Faria, Ana Calhau, Conceição Marques, Cláudia Microorganisms Review Intestinal alkaline phosphatase (IALP) has recently assumed a special relevance, being the subject of study in the prevention and treatment of certain diseases related to leaky gut. This brush border enzyme (ecto-enzyme) plays an important role in the maintenance of intestinal microbial homeostasis and intestinal barrier function through its ability to dephosphorylate lipopolysaccharide (LPS). This review addresses how IALP and intestinal barrier dysfunction may be implicated in the pathophysiology of specific diseases such as inflammatory bowel disease, necrotizing enterocolitis, and metabolic syndrome. The use of IALP as a possible biomarker to assess intestinal barrier function and strategies to modulate IALP activity are also discussed. MDPI 2022-03-30 /pmc/articles/PMC9026380/ /pubmed/35456797 http://dx.doi.org/10.3390/microorganisms10040746 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Santos, Gilberto Maia
Ismael, Shámila
Morais, Juliana
Araújo, João R.
Faria, Ana
Calhau, Conceição
Marques, Cláudia
Intestinal Alkaline Phosphatase: A Review of This Enzyme Role in the Intestinal Barrier Function
title Intestinal Alkaline Phosphatase: A Review of This Enzyme Role in the Intestinal Barrier Function
title_full Intestinal Alkaline Phosphatase: A Review of This Enzyme Role in the Intestinal Barrier Function
title_fullStr Intestinal Alkaline Phosphatase: A Review of This Enzyme Role in the Intestinal Barrier Function
title_full_unstemmed Intestinal Alkaline Phosphatase: A Review of This Enzyme Role in the Intestinal Barrier Function
title_short Intestinal Alkaline Phosphatase: A Review of This Enzyme Role in the Intestinal Barrier Function
title_sort intestinal alkaline phosphatase: a review of this enzyme role in the intestinal barrier function
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9026380/
https://www.ncbi.nlm.nih.gov/pubmed/35456797
http://dx.doi.org/10.3390/microorganisms10040746
work_keys_str_mv AT santosgilbertomaia intestinalalkalinephosphataseareviewofthisenzymeroleintheintestinalbarrierfunction
AT ismaelshamila intestinalalkalinephosphataseareviewofthisenzymeroleintheintestinalbarrierfunction
AT moraisjuliana intestinalalkalinephosphataseareviewofthisenzymeroleintheintestinalbarrierfunction
AT araujojoaor intestinalalkalinephosphataseareviewofthisenzymeroleintheintestinalbarrierfunction
AT fariaana intestinalalkalinephosphataseareviewofthisenzymeroleintheintestinalbarrierfunction
AT calhauconceicao intestinalalkalinephosphataseareviewofthisenzymeroleintheintestinalbarrierfunction
AT marquesclaudia intestinalalkalinephosphataseareviewofthisenzymeroleintheintestinalbarrierfunction

Ejemplares similares