Elevated Gamma Connectivity in Nidopallium Caudolaterale of Pigeons during Spatial Path Adjustment

SIMPLE SUMMARY: Imagine that you need to reach a designated destination, but the familiar path you most often choose suddenly becomes impassable. Then, what will you do? Of course, you will try to adjust the path according to your cognition of the current environment and the goal. During this, how will be the spatial environment, especially the path adjustment process, be represented in your brain? That is a very interesting research topic. In this study, we attempted to explore the internal neural patterns within the brain, especially within the higher-order cognitive brain areas, by taking pigeons, a species with excellent navigation ability, as a model animal. The most classical detour paradigm was used to train pigeons in a task of spatial path adjustment, and the neural signals in pigeons’ nidopallium caudolaterale ((NCL) functionally similar to mammalian “prefrontal cortex”) were recorded. We found that the spatial path adjustment process is accompanied by modifications of the changes in spectral and connectivity properties of the neural activities in the NCL. The elevated gamma connectivity in the NCL found in this study supports the role of the NCL in spatial cognition and contributes to explaining the potential neural mechanism of path adjustment. ABSTRACT: Previous studies showed that spatial navigation depends on a local network including multiple brain regions with strong interactions. However, it is still not fully understood whether and how the neural patterns in avian nidopallium caudolaterale (NCL), which is suggested to play a key role in navigation as a higher cognitive structure, are modulated by the behaviors during spatial navigation, especially involved path adjustment needs. Hence, we examined neural activity in the NCL of pigeons and explored the local field potentials’ (LFPs) spectral and functional connectivity patterns in a goal-directed spatial cognitive task with the detour paradigm. We found the pigeons progressively learned to solve the path adjustment task when the learned path was blocked suddenly. Importantly, the behavioral changes during the adjustment were accompanied by the modifications in neural patterns in the NCL. Specifically, the spectral power in lower bands (1–4 Hz and 5–12 Hz) decreased as the pigeons were tested during the adjustment. Meanwhile, an elevated gamma (31–45 Hz and 55–80 Hz) connectivity in the NCL was also detected. These results and the partial least square discriminant analysis (PLS-DA) modeling analysis provide insights into the neural activities in the avian NCL during the spatial path adjustment, contributing to understanding the potential mechanism of avian spatial encoding. This study suggests the important role of the NCL in spatial learning, especially path adjustment in avian navigation.