Cargando…
Interplay between Fatty Acid Binding Protein 4, Fetuin-A, Retinol Binding Protein 4 and Thyroid Function in Metabolic Dysregulation
Signalling between the tissues integrating synthesis, transformation and utilization of energy substrates and their regulatory hormonal axes play a substantial role in the development of metabolic disorders. Interactions between cytokines, particularly liver derived hepatokines and adipokines, secre...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9026429/ https://www.ncbi.nlm.nih.gov/pubmed/35448487 http://dx.doi.org/10.3390/metabo12040300 |
_version_ | 1784691120005971968 |
---|---|
author | Dadej, Daniela Szczepanek-Parulska, Ewelina Ruchała, Marek |
author_facet | Dadej, Daniela Szczepanek-Parulska, Ewelina Ruchała, Marek |
author_sort | Dadej, Daniela |
collection | PubMed |
description | Signalling between the tissues integrating synthesis, transformation and utilization of energy substrates and their regulatory hormonal axes play a substantial role in the development of metabolic disorders. Interactions between cytokines, particularly liver derived hepatokines and adipokines, secreted from adipose tissue, constitute one of major areas of current research devoted to metabolic dysregulation. The thyroid exerts crucial influence on the maintenance of basal metabolic rate, thermogenesis, carbohydrate and lipid metabolism, while its dysfunction promotes the development of metabolic disorders. In this review, we discuss the interplay between three adipokines: fatty acid binding protein type 4, fetuin-A, retinol binding protein type 4 and thyroid hormones, that shed a new light onto mechanisms underlying atherosclerosis, cardiovascular complications, obesity, insulin resistance and diabetes accompanying thyroid dysfunction. Furthermore, we summarize clinical findings on those cytokines in the course of thyroid disorders. |
format | Online Article Text |
id | pubmed-9026429 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90264292022-04-23 Interplay between Fatty Acid Binding Protein 4, Fetuin-A, Retinol Binding Protein 4 and Thyroid Function in Metabolic Dysregulation Dadej, Daniela Szczepanek-Parulska, Ewelina Ruchała, Marek Metabolites Review Signalling between the tissues integrating synthesis, transformation and utilization of energy substrates and their regulatory hormonal axes play a substantial role in the development of metabolic disorders. Interactions between cytokines, particularly liver derived hepatokines and adipokines, secreted from adipose tissue, constitute one of major areas of current research devoted to metabolic dysregulation. The thyroid exerts crucial influence on the maintenance of basal metabolic rate, thermogenesis, carbohydrate and lipid metabolism, while its dysfunction promotes the development of metabolic disorders. In this review, we discuss the interplay between three adipokines: fatty acid binding protein type 4, fetuin-A, retinol binding protein type 4 and thyroid hormones, that shed a new light onto mechanisms underlying atherosclerosis, cardiovascular complications, obesity, insulin resistance and diabetes accompanying thyroid dysfunction. Furthermore, we summarize clinical findings on those cytokines in the course of thyroid disorders. MDPI 2022-03-29 /pmc/articles/PMC9026429/ /pubmed/35448487 http://dx.doi.org/10.3390/metabo12040300 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Dadej, Daniela Szczepanek-Parulska, Ewelina Ruchała, Marek Interplay between Fatty Acid Binding Protein 4, Fetuin-A, Retinol Binding Protein 4 and Thyroid Function in Metabolic Dysregulation |
title | Interplay between Fatty Acid Binding Protein 4, Fetuin-A, Retinol Binding Protein 4 and Thyroid Function in Metabolic Dysregulation |
title_full | Interplay between Fatty Acid Binding Protein 4, Fetuin-A, Retinol Binding Protein 4 and Thyroid Function in Metabolic Dysregulation |
title_fullStr | Interplay between Fatty Acid Binding Protein 4, Fetuin-A, Retinol Binding Protein 4 and Thyroid Function in Metabolic Dysregulation |
title_full_unstemmed | Interplay between Fatty Acid Binding Protein 4, Fetuin-A, Retinol Binding Protein 4 and Thyroid Function in Metabolic Dysregulation |
title_short | Interplay between Fatty Acid Binding Protein 4, Fetuin-A, Retinol Binding Protein 4 and Thyroid Function in Metabolic Dysregulation |
title_sort | interplay between fatty acid binding protein 4, fetuin-a, retinol binding protein 4 and thyroid function in metabolic dysregulation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9026429/ https://www.ncbi.nlm.nih.gov/pubmed/35448487 http://dx.doi.org/10.3390/metabo12040300 |
work_keys_str_mv | AT dadejdaniela interplaybetweenfattyacidbindingprotein4fetuinaretinolbindingprotein4andthyroidfunctioninmetabolicdysregulation AT szczepanekparulskaewelina interplaybetweenfattyacidbindingprotein4fetuinaretinolbindingprotein4andthyroidfunctioninmetabolicdysregulation AT ruchałamarek interplaybetweenfattyacidbindingprotein4fetuinaretinolbindingprotein4andthyroidfunctioninmetabolicdysregulation |