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Aromatic Acids and Leucine Derivatives Produced from the Deep-Sea Actinomycetes Streptomyces chumphonensis SCSIO15079 with Antihyperlipidemic Activities
Six new aromatic acids (1–6) and three new leucine derivatives containing an unusual oxime moiety (7–9) were isolated and identified from the deep-sea-derived actinomycetes strain Streptomyces chumphonensis SCSIO15079, together with two known compounds (10–11). The structures of 1–9 including absolu...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9026450/ https://www.ncbi.nlm.nih.gov/pubmed/35447932 http://dx.doi.org/10.3390/md20040259 |
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author | Su, Ziqi Li, Kunlong Luo, Xiaowei Zhu, Yongyan Mai, Shao-Yu Zhu, Quanhong Yang, Bin Zhou, Xuefeng Tao, Huaming |
author_facet | Su, Ziqi Li, Kunlong Luo, Xiaowei Zhu, Yongyan Mai, Shao-Yu Zhu, Quanhong Yang, Bin Zhou, Xuefeng Tao, Huaming |
author_sort | Su, Ziqi |
collection | PubMed |
description | Six new aromatic acids (1–6) and three new leucine derivatives containing an unusual oxime moiety (7–9) were isolated and identified from the deep-sea-derived actinomycetes strain Streptomyces chumphonensis SCSIO15079, together with two known compounds (10–11). The structures of 1–9 including absolute configurations were determined by detailed NMR, MS, and experimental and calculated electronic circular dichroism spectroscopic analyses. Compounds 1–9 were evaluated for their antimicrobial and cytotoxicity activities, as well as their effects on intracellular lipid accumulation in HepG2 cells. Compounds 3 and 4, with the most potent inhibitory activity on intracellular lipid accumulation at 10 μM, were revealed with potential antihyperlipidemic effects, although the mechanism needs to be further studied. |
format | Online Article Text |
id | pubmed-9026450 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90264502022-04-23 Aromatic Acids and Leucine Derivatives Produced from the Deep-Sea Actinomycetes Streptomyces chumphonensis SCSIO15079 with Antihyperlipidemic Activities Su, Ziqi Li, Kunlong Luo, Xiaowei Zhu, Yongyan Mai, Shao-Yu Zhu, Quanhong Yang, Bin Zhou, Xuefeng Tao, Huaming Mar Drugs Article Six new aromatic acids (1–6) and three new leucine derivatives containing an unusual oxime moiety (7–9) were isolated and identified from the deep-sea-derived actinomycetes strain Streptomyces chumphonensis SCSIO15079, together with two known compounds (10–11). The structures of 1–9 including absolute configurations were determined by detailed NMR, MS, and experimental and calculated electronic circular dichroism spectroscopic analyses. Compounds 1–9 were evaluated for their antimicrobial and cytotoxicity activities, as well as their effects on intracellular lipid accumulation in HepG2 cells. Compounds 3 and 4, with the most potent inhibitory activity on intracellular lipid accumulation at 10 μM, were revealed with potential antihyperlipidemic effects, although the mechanism needs to be further studied. MDPI 2022-04-07 /pmc/articles/PMC9026450/ /pubmed/35447932 http://dx.doi.org/10.3390/md20040259 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Su, Ziqi Li, Kunlong Luo, Xiaowei Zhu, Yongyan Mai, Shao-Yu Zhu, Quanhong Yang, Bin Zhou, Xuefeng Tao, Huaming Aromatic Acids and Leucine Derivatives Produced from the Deep-Sea Actinomycetes Streptomyces chumphonensis SCSIO15079 with Antihyperlipidemic Activities |
title | Aromatic Acids and Leucine Derivatives Produced from the Deep-Sea Actinomycetes Streptomyces
chumphonensis SCSIO15079 with Antihyperlipidemic Activities |
title_full | Aromatic Acids and Leucine Derivatives Produced from the Deep-Sea Actinomycetes Streptomyces
chumphonensis SCSIO15079 with Antihyperlipidemic Activities |
title_fullStr | Aromatic Acids and Leucine Derivatives Produced from the Deep-Sea Actinomycetes Streptomyces
chumphonensis SCSIO15079 with Antihyperlipidemic Activities |
title_full_unstemmed | Aromatic Acids and Leucine Derivatives Produced from the Deep-Sea Actinomycetes Streptomyces
chumphonensis SCSIO15079 with Antihyperlipidemic Activities |
title_short | Aromatic Acids and Leucine Derivatives Produced from the Deep-Sea Actinomycetes Streptomyces
chumphonensis SCSIO15079 with Antihyperlipidemic Activities |
title_sort | aromatic acids and leucine derivatives produced from the deep-sea actinomycetes streptomyces
chumphonensis scsio15079 with antihyperlipidemic activities |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9026450/ https://www.ncbi.nlm.nih.gov/pubmed/35447932 http://dx.doi.org/10.3390/md20040259 |
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