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Aromatic Acids and Leucine Derivatives Produced from the Deep-Sea Actinomycetes Streptomyces chumphonensis SCSIO15079 with Antihyperlipidemic Activities

Six new aromatic acids (1–6) and three new leucine derivatives containing an unusual oxime moiety (7–9) were isolated and identified from the deep-sea-derived actinomycetes strain Streptomyces chumphonensis SCSIO15079, together with two known compounds (10–11). The structures of 1–9 including absolu...

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Autores principales: Su, Ziqi, Li, Kunlong, Luo, Xiaowei, Zhu, Yongyan, Mai, Shao-Yu, Zhu, Quanhong, Yang, Bin, Zhou, Xuefeng, Tao, Huaming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9026450/
https://www.ncbi.nlm.nih.gov/pubmed/35447932
http://dx.doi.org/10.3390/md20040259
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author Su, Ziqi
Li, Kunlong
Luo, Xiaowei
Zhu, Yongyan
Mai, Shao-Yu
Zhu, Quanhong
Yang, Bin
Zhou, Xuefeng
Tao, Huaming
author_facet Su, Ziqi
Li, Kunlong
Luo, Xiaowei
Zhu, Yongyan
Mai, Shao-Yu
Zhu, Quanhong
Yang, Bin
Zhou, Xuefeng
Tao, Huaming
author_sort Su, Ziqi
collection PubMed
description Six new aromatic acids (1–6) and three new leucine derivatives containing an unusual oxime moiety (7–9) were isolated and identified from the deep-sea-derived actinomycetes strain Streptomyces chumphonensis SCSIO15079, together with two known compounds (10–11). The structures of 1–9 including absolute configurations were determined by detailed NMR, MS, and experimental and calculated electronic circular dichroism spectroscopic analyses. Compounds 1–9 were evaluated for their antimicrobial and cytotoxicity activities, as well as their effects on intracellular lipid accumulation in HepG2 cells. Compounds 3 and 4, with the most potent inhibitory activity on intracellular lipid accumulation at 10 μM, were revealed with potential antihyperlipidemic effects, although the mechanism needs to be further studied.
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spelling pubmed-90264502022-04-23 Aromatic Acids and Leucine Derivatives Produced from the Deep-Sea Actinomycetes Streptomyces chumphonensis SCSIO15079 with Antihyperlipidemic Activities Su, Ziqi Li, Kunlong Luo, Xiaowei Zhu, Yongyan Mai, Shao-Yu Zhu, Quanhong Yang, Bin Zhou, Xuefeng Tao, Huaming Mar Drugs Article Six new aromatic acids (1–6) and three new leucine derivatives containing an unusual oxime moiety (7–9) were isolated and identified from the deep-sea-derived actinomycetes strain Streptomyces chumphonensis SCSIO15079, together with two known compounds (10–11). The structures of 1–9 including absolute configurations were determined by detailed NMR, MS, and experimental and calculated electronic circular dichroism spectroscopic analyses. Compounds 1–9 were evaluated for their antimicrobial and cytotoxicity activities, as well as their effects on intracellular lipid accumulation in HepG2 cells. Compounds 3 and 4, with the most potent inhibitory activity on intracellular lipid accumulation at 10 μM, were revealed with potential antihyperlipidemic effects, although the mechanism needs to be further studied. MDPI 2022-04-07 /pmc/articles/PMC9026450/ /pubmed/35447932 http://dx.doi.org/10.3390/md20040259 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Su, Ziqi
Li, Kunlong
Luo, Xiaowei
Zhu, Yongyan
Mai, Shao-Yu
Zhu, Quanhong
Yang, Bin
Zhou, Xuefeng
Tao, Huaming
Aromatic Acids and Leucine Derivatives Produced from the Deep-Sea Actinomycetes Streptomyces chumphonensis SCSIO15079 with Antihyperlipidemic Activities
title Aromatic Acids and Leucine Derivatives Produced from the Deep-Sea Actinomycetes Streptomyces chumphonensis SCSIO15079 with Antihyperlipidemic Activities
title_full Aromatic Acids and Leucine Derivatives Produced from the Deep-Sea Actinomycetes Streptomyces chumphonensis SCSIO15079 with Antihyperlipidemic Activities
title_fullStr Aromatic Acids and Leucine Derivatives Produced from the Deep-Sea Actinomycetes Streptomyces chumphonensis SCSIO15079 with Antihyperlipidemic Activities
title_full_unstemmed Aromatic Acids and Leucine Derivatives Produced from the Deep-Sea Actinomycetes Streptomyces chumphonensis SCSIO15079 with Antihyperlipidemic Activities
title_short Aromatic Acids and Leucine Derivatives Produced from the Deep-Sea Actinomycetes Streptomyces chumphonensis SCSIO15079 with Antihyperlipidemic Activities
title_sort aromatic acids and leucine derivatives produced from the deep-sea actinomycetes streptomyces chumphonensis scsio15079 with antihyperlipidemic activities
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9026450/
https://www.ncbi.nlm.nih.gov/pubmed/35447932
http://dx.doi.org/10.3390/md20040259
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