Cargando…

Message in a Bottle: Endothelial Cell Regulation by Extracellular Vesicles

SIMPLE SUMMARY: Elucidating the role of extracellular vesicles (EVs) in the communication mechanisms between cancer and endothelial cells (ECs) within the tumor microenvironment is an exciting challenge. At the same time, due to their ability to convey bioactive molecules, EVs may be potentially rel...

Descripción completa

Detalles Bibliográficos
Autores principales: Palazzo, Claudia, D’Alessio, Alessio, Tamagnone, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9026533/
https://www.ncbi.nlm.nih.gov/pubmed/35454874
http://dx.doi.org/10.3390/cancers14081969
_version_ 1784691145638412288
author Palazzo, Claudia
D’Alessio, Alessio
Tamagnone, Luca
author_facet Palazzo, Claudia
D’Alessio, Alessio
Tamagnone, Luca
author_sort Palazzo, Claudia
collection PubMed
description SIMPLE SUMMARY: Elucidating the role of extracellular vesicles (EVs) in the communication mechanisms between cancer and endothelial cells (ECs) within the tumor microenvironment is an exciting challenge. At the same time, due to their ability to convey bioactive molecules, EVs may be potentially relevant from a therapeutic perspective for diverse vascular pathologies. ABSTRACT: Intercellular communication is a key biological mechanism that is fundamental to maintain tissue homeostasis. Extracellular vesicles (EVs) have emerged as critical regulators of cell–cell communication in both physiological and pathological conditions, due to their ability to shuttle a variety of cell constituents, such as DNA, RNA, lipids, active metabolites, cytosolic, and cell surface proteins. In particular, endothelial cells (ECs) are prominently regulated by EVs released by neighboring cell types. The discovery that cancer cell-derived EVs can control the functions of ECs has prompted the investigation of their roles in tumor angiogenesis and cancer progression. In particular, here, we discuss evidence that supports the roles of exosomes in EC regulation within the tumor microenvironment and in vascular dysfunction leading to atherosclerosis. Moreover, we survey the molecular mechanisms and exosomal cargoes that have been implicated in explanations of these regulatory effects.
format Online
Article
Text
id pubmed-9026533
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-90265332022-04-23 Message in a Bottle: Endothelial Cell Regulation by Extracellular Vesicles Palazzo, Claudia D’Alessio, Alessio Tamagnone, Luca Cancers (Basel) Review SIMPLE SUMMARY: Elucidating the role of extracellular vesicles (EVs) in the communication mechanisms between cancer and endothelial cells (ECs) within the tumor microenvironment is an exciting challenge. At the same time, due to their ability to convey bioactive molecules, EVs may be potentially relevant from a therapeutic perspective for diverse vascular pathologies. ABSTRACT: Intercellular communication is a key biological mechanism that is fundamental to maintain tissue homeostasis. Extracellular vesicles (EVs) have emerged as critical regulators of cell–cell communication in both physiological and pathological conditions, due to their ability to shuttle a variety of cell constituents, such as DNA, RNA, lipids, active metabolites, cytosolic, and cell surface proteins. In particular, endothelial cells (ECs) are prominently regulated by EVs released by neighboring cell types. The discovery that cancer cell-derived EVs can control the functions of ECs has prompted the investigation of their roles in tumor angiogenesis and cancer progression. In particular, here, we discuss evidence that supports the roles of exosomes in EC regulation within the tumor microenvironment and in vascular dysfunction leading to atherosclerosis. Moreover, we survey the molecular mechanisms and exosomal cargoes that have been implicated in explanations of these regulatory effects. MDPI 2022-04-13 /pmc/articles/PMC9026533/ /pubmed/35454874 http://dx.doi.org/10.3390/cancers14081969 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Palazzo, Claudia
D’Alessio, Alessio
Tamagnone, Luca
Message in a Bottle: Endothelial Cell Regulation by Extracellular Vesicles
title Message in a Bottle: Endothelial Cell Regulation by Extracellular Vesicles
title_full Message in a Bottle: Endothelial Cell Regulation by Extracellular Vesicles
title_fullStr Message in a Bottle: Endothelial Cell Regulation by Extracellular Vesicles
title_full_unstemmed Message in a Bottle: Endothelial Cell Regulation by Extracellular Vesicles
title_short Message in a Bottle: Endothelial Cell Regulation by Extracellular Vesicles
title_sort message in a bottle: endothelial cell regulation by extracellular vesicles
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9026533/
https://www.ncbi.nlm.nih.gov/pubmed/35454874
http://dx.doi.org/10.3390/cancers14081969
work_keys_str_mv AT palazzoclaudia messageinabottleendothelialcellregulationbyextracellularvesicles
AT dalessioalessio messageinabottleendothelialcellregulationbyextracellularvesicles
AT tamagnoneluca messageinabottleendothelialcellregulationbyextracellularvesicles