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Low-coverage whole-genome sequencing of cerebrospinal-fluid-derived cell-free DNA in brain tumor patients

This protocol summarizes the pipeline for analysis of tumor-derived cell-free DNA (cfDNA) from cerebrospinal fluid (CSF) using low-coverage whole-genome sequencing (lcWGS). This approach enables resolution of chromosomal and focal copy-number variations (CNVs) as oncologic signatures, particularly f...

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Detalles Bibliográficos
Autores principales:	Liu, Anthony P.Y., Smith, Kyle S., Kumar, Rahul, Robinson, Giles W., Northcott, Paul A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Protocol
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9026582/ https://www.ncbi.nlm.nih.gov/pubmed/35463474 http://dx.doi.org/10.1016/j.xpro.2022.101292

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