miR-124-3p delivered by exosomes from heme oxygenase-1 modified bone marrow mesenchymal stem cells inhibits ferroptosis to attenuate ischemia–reperfusion injury in steatotic grafts

BACKGROUND: Steatotic livers tolerate ischemia–reperfusion injury (IRI) poorly, increasing the risk of organ dysfunction. Ferroptosis is considered the initiating factor of organ IRI. Heme oxygenase oxygen-1 (HO-1)-modified bone marrow mesenchymal stem cells (BMMSCs) (HO-1/BMMSCs) can reduce hepatic...

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Detalles Bibliográficos
Autores principales: Wu, Longlong, Tian, Xuan, Zuo, Huaiwen, Zheng, Weiping, Li, Xiang, Yuan, Mengshu, Tian, Xiaorong, Song, Hongli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9026664/
https://www.ncbi.nlm.nih.gov/pubmed/35459211
http://dx.doi.org/10.1186/s12951-022-01407-8

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