Huaier Polysaccharide Interrupts PRV Infection via Reducing Virus Adsorption and Entry

A pseudorabies virus (PRV) novel virulent variant outbreak occurred in China in 2011. However, little is known about PRV prevention and treatment. Huaier polysaccharide has been used to treat some solid cancers, although its antiviral activity has not been reported. Our study confirmed that the poly...

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Autores principales: Huan, Changchao, Yao, Jingting, Xu, Weiyin, Zhang, Wei, Zhou, Ziyan, Pan, Haochun, Gao, Song
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9026689/
https://www.ncbi.nlm.nih.gov/pubmed/35458475
http://dx.doi.org/10.3390/v14040745
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author Huan, Changchao
Yao, Jingting
Xu, Weiyin
Zhang, Wei
Zhou, Ziyan
Pan, Haochun
Gao, Song
author_facet Huan, Changchao
Yao, Jingting
Xu, Weiyin
Zhang, Wei
Zhou, Ziyan
Pan, Haochun
Gao, Song
author_sort Huan, Changchao
collection PubMed
description A pseudorabies virus (PRV) novel virulent variant outbreak occurred in China in 2011. However, little is known about PRV prevention and treatment. Huaier polysaccharide has been used to treat some solid cancers, although its antiviral activity has not been reported. Our study confirmed that the polysaccharide can effectively inhibit infection of PRV XJ5 in PK15 cells. It acted in a dose-dependent manner when blocking virus adsorption and entry into PK15 cells. Moreover, it suppressed PRV replication in PK15 cells. In addition, the results suggest that Huaier polysaccharide plays a role in treating PRV XJ5 infection by directly inactivating PRV XJ5. In conclusion, Huaier polysaccharide might be a novel therapeutic agent for preventing and controlling PRV infection.
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spelling pubmed-90266892022-04-23 Huaier Polysaccharide Interrupts PRV Infection via Reducing Virus Adsorption and Entry Huan, Changchao Yao, Jingting Xu, Weiyin Zhang, Wei Zhou, Ziyan Pan, Haochun Gao, Song Viruses Article A pseudorabies virus (PRV) novel virulent variant outbreak occurred in China in 2011. However, little is known about PRV prevention and treatment. Huaier polysaccharide has been used to treat some solid cancers, although its antiviral activity has not been reported. Our study confirmed that the polysaccharide can effectively inhibit infection of PRV XJ5 in PK15 cells. It acted in a dose-dependent manner when blocking virus adsorption and entry into PK15 cells. Moreover, it suppressed PRV replication in PK15 cells. In addition, the results suggest that Huaier polysaccharide plays a role in treating PRV XJ5 infection by directly inactivating PRV XJ5. In conclusion, Huaier polysaccharide might be a novel therapeutic agent for preventing and controlling PRV infection. MDPI 2022-04-01 /pmc/articles/PMC9026689/ /pubmed/35458475 http://dx.doi.org/10.3390/v14040745 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Huan, Changchao
Yao, Jingting
Xu, Weiyin
Zhang, Wei
Zhou, Ziyan
Pan, Haochun
Gao, Song
Huaier Polysaccharide Interrupts PRV Infection via Reducing Virus Adsorption and Entry
title Huaier Polysaccharide Interrupts PRV Infection via Reducing Virus Adsorption and Entry
title_full Huaier Polysaccharide Interrupts PRV Infection via Reducing Virus Adsorption and Entry
title_fullStr Huaier Polysaccharide Interrupts PRV Infection via Reducing Virus Adsorption and Entry
title_full_unstemmed Huaier Polysaccharide Interrupts PRV Infection via Reducing Virus Adsorption and Entry
title_short Huaier Polysaccharide Interrupts PRV Infection via Reducing Virus Adsorption and Entry
title_sort huaier polysaccharide interrupts prv infection via reducing virus adsorption and entry
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9026689/
https://www.ncbi.nlm.nih.gov/pubmed/35458475
http://dx.doi.org/10.3390/v14040745
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