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Applications of Metal-Organic Frameworks as Drug Delivery Systems

In the last decade, metal organic frameworks (MOFs) have shown great prospective as new drug delivery systems (DDSs) due to their unique properties: these materials exhibit fascinating architectures, surfaces, composition, and a rich chemistry of these compounds. The DSSs allow the release of the ac...

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Detalles Bibliográficos
Autores principales: Maranescu, Bianca, Visa, Aurelia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9026733/
https://www.ncbi.nlm.nih.gov/pubmed/35457275
http://dx.doi.org/10.3390/ijms23084458
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author Maranescu, Bianca
Visa, Aurelia
author_facet Maranescu, Bianca
Visa, Aurelia
author_sort Maranescu, Bianca
collection PubMed
description In the last decade, metal organic frameworks (MOFs) have shown great prospective as new drug delivery systems (DDSs) due to their unique properties: these materials exhibit fascinating architectures, surfaces, composition, and a rich chemistry of these compounds. The DSSs allow the release of the active pharmaceutical ingredient to accomplish a desired therapeutic response. Over the past few decades, there has been exponential growth of many new classes of coordination polymers, and MOFs have gained popularity over other identified systems due to their higher biocompatibility and versatile loading capabilities. This review presents and assesses the most recent research, findings, and challenges associated with the use of MOFs as DDSs. Among the most commonly used MOFs for investigated-purpose MOFs, coordination polymers and metal complexes based on synthetic and natural polymers, are well known. Specific attention is given to the stimuli- and multistimuli-responsive MOFs-based DDSs. Of great interest in the COVID-19 pandemic is the use of MOFs for combination therapy and multimodal systems.
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spelling pubmed-90267332022-04-23 Applications of Metal-Organic Frameworks as Drug Delivery Systems Maranescu, Bianca Visa, Aurelia Int J Mol Sci Review In the last decade, metal organic frameworks (MOFs) have shown great prospective as new drug delivery systems (DDSs) due to their unique properties: these materials exhibit fascinating architectures, surfaces, composition, and a rich chemistry of these compounds. The DSSs allow the release of the active pharmaceutical ingredient to accomplish a desired therapeutic response. Over the past few decades, there has been exponential growth of many new classes of coordination polymers, and MOFs have gained popularity over other identified systems due to their higher biocompatibility and versatile loading capabilities. This review presents and assesses the most recent research, findings, and challenges associated with the use of MOFs as DDSs. Among the most commonly used MOFs for investigated-purpose MOFs, coordination polymers and metal complexes based on synthetic and natural polymers, are well known. Specific attention is given to the stimuli- and multistimuli-responsive MOFs-based DDSs. Of great interest in the COVID-19 pandemic is the use of MOFs for combination therapy and multimodal systems. MDPI 2022-04-18 /pmc/articles/PMC9026733/ /pubmed/35457275 http://dx.doi.org/10.3390/ijms23084458 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Maranescu, Bianca
Visa, Aurelia
Applications of Metal-Organic Frameworks as Drug Delivery Systems
title Applications of Metal-Organic Frameworks as Drug Delivery Systems
title_full Applications of Metal-Organic Frameworks as Drug Delivery Systems
title_fullStr Applications of Metal-Organic Frameworks as Drug Delivery Systems
title_full_unstemmed Applications of Metal-Organic Frameworks as Drug Delivery Systems
title_short Applications of Metal-Organic Frameworks as Drug Delivery Systems
title_sort applications of metal-organic frameworks as drug delivery systems
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9026733/
https://www.ncbi.nlm.nih.gov/pubmed/35457275
http://dx.doi.org/10.3390/ijms23084458
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