Cargando…

Association between Stress Hyperglycemia and Adverse Outcomes in Children Visiting the Pediatric Emergency Department

Stress hyperglycemia (SH) is often identified in patients visiting the pediatric emergency department (PED), and SH in adults has been associated with adverse outcomes, including mortality. In this retrospective study, we determined the adverse outcomes according to blood glucose (BG) levels of chil...

Descripción completa

Detalles Bibliográficos
Autores principales: Bae, Woori, Ahn, Moon Bae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9026823/
https://www.ncbi.nlm.nih.gov/pubmed/35455548
http://dx.doi.org/10.3390/children9040505
_version_ 1784691207572553728
author Bae, Woori
Ahn, Moon Bae
author_facet Bae, Woori
Ahn, Moon Bae
author_sort Bae, Woori
collection PubMed
description Stress hyperglycemia (SH) is often identified in patients visiting the pediatric emergency department (PED), and SH in adults has been associated with adverse outcomes, including mortality. In this retrospective study, we determined the adverse outcomes according to blood glucose (BG) levels of children visiting the PED of tertiary hospitals. Data were collected from the electronic medical records of children aged <18 years between 1 January 2011 and 31 December 2020. A total of 44,905 visits were included in the analysis. SH was identified in 1506 patients, with an incidence rate of 3.4%. Compared to those without SH, patients with SH had significantly higher ward admission rates (52.6% vs. 35.9%, p < 0.001), intensive care unit admission rates (2.6% vs. 0.7%, p < 0.001), and mortality rates (2.7% vs. 0.3%, p < 0.001). Compared to the normoglycemic group of 45 ≤ BG < 150 mg/dL, the odds ratios (95% CI) for mortality were 5.61 (3.35–9.37), 27.96 (14.95–52.26), 44.22 (17.03–114.82), and 39.94 (16.31–97.81) for levels 150 ≤ BG < 200, 200 ≤ BG < 250, 250 ≤ BG < 300 and ≥300 mg/dL, respectively. This suggests that SH is common in children visiting the PED and is associated with higher adverse outcomes. Thus, there is a need to quickly identify its cause and take prompt intervention to resolve it.
format Online
Article
Text
id pubmed-9026823
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-90268232022-04-23 Association between Stress Hyperglycemia and Adverse Outcomes in Children Visiting the Pediatric Emergency Department Bae, Woori Ahn, Moon Bae Children (Basel) Article Stress hyperglycemia (SH) is often identified in patients visiting the pediatric emergency department (PED), and SH in adults has been associated with adverse outcomes, including mortality. In this retrospective study, we determined the adverse outcomes according to blood glucose (BG) levels of children visiting the PED of tertiary hospitals. Data were collected from the electronic medical records of children aged <18 years between 1 January 2011 and 31 December 2020. A total of 44,905 visits were included in the analysis. SH was identified in 1506 patients, with an incidence rate of 3.4%. Compared to those without SH, patients with SH had significantly higher ward admission rates (52.6% vs. 35.9%, p < 0.001), intensive care unit admission rates (2.6% vs. 0.7%, p < 0.001), and mortality rates (2.7% vs. 0.3%, p < 0.001). Compared to the normoglycemic group of 45 ≤ BG < 150 mg/dL, the odds ratios (95% CI) for mortality were 5.61 (3.35–9.37), 27.96 (14.95–52.26), 44.22 (17.03–114.82), and 39.94 (16.31–97.81) for levels 150 ≤ BG < 200, 200 ≤ BG < 250, 250 ≤ BG < 300 and ≥300 mg/dL, respectively. This suggests that SH is common in children visiting the PED and is associated with higher adverse outcomes. Thus, there is a need to quickly identify its cause and take prompt intervention to resolve it. MDPI 2022-04-02 /pmc/articles/PMC9026823/ /pubmed/35455548 http://dx.doi.org/10.3390/children9040505 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bae, Woori
Ahn, Moon Bae
Association between Stress Hyperglycemia and Adverse Outcomes in Children Visiting the Pediatric Emergency Department
title Association between Stress Hyperglycemia and Adverse Outcomes in Children Visiting the Pediatric Emergency Department
title_full Association between Stress Hyperglycemia and Adverse Outcomes in Children Visiting the Pediatric Emergency Department
title_fullStr Association between Stress Hyperglycemia and Adverse Outcomes in Children Visiting the Pediatric Emergency Department
title_full_unstemmed Association between Stress Hyperglycemia and Adverse Outcomes in Children Visiting the Pediatric Emergency Department
title_short Association between Stress Hyperglycemia and Adverse Outcomes in Children Visiting the Pediatric Emergency Department
title_sort association between stress hyperglycemia and adverse outcomes in children visiting the pediatric emergency department
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9026823/
https://www.ncbi.nlm.nih.gov/pubmed/35455548
http://dx.doi.org/10.3390/children9040505
work_keys_str_mv AT baewoori associationbetweenstresshyperglycemiaandadverseoutcomesinchildrenvisitingthepediatricemergencydepartment
AT ahnmoonbae associationbetweenstresshyperglycemiaandadverseoutcomesinchildrenvisitingthepediatricemergencydepartment