Cargando…
Nonalcoholic Fatty Liver Disease and Endocrine Axes—A Scoping Review
Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease. NAFLD often occurs associated with endocrinopathies. Evidence suggests that endocrine dysfunction may play an important role in NAFLD development, progression, and severity. Our work aimed to explore and summariz...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9026925/ https://www.ncbi.nlm.nih.gov/pubmed/35448486 http://dx.doi.org/10.3390/metabo12040298 |
_version_ | 1784691233112719360 |
---|---|
author | Von-Hafe, Madalena Borges-Canha, Marta Vale, Catarina Leite, Ana Rita Sérgio Neves, João Carvalho, Davide Leite-Moreira, Adelino |
author_facet | Von-Hafe, Madalena Borges-Canha, Marta Vale, Catarina Leite, Ana Rita Sérgio Neves, João Carvalho, Davide Leite-Moreira, Adelino |
author_sort | Von-Hafe, Madalena |
collection | PubMed |
description | Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease. NAFLD often occurs associated with endocrinopathies. Evidence suggests that endocrine dysfunction may play an important role in NAFLD development, progression, and severity. Our work aimed to explore and summarize the crosstalk between the liver and different endocrine organs, their hormones, and dysfunctions. For instance, our results show that hyperprolactinemia, hypercortisolemia, and polycystic ovary syndrome seem to worsen NAFLD’s pathway. Hypothyroidism and low growth hormone levels also may contribute to NAFLD’s progression, and a bidirectional association between hypercortisolism and hypogonadism and the NAFLD pathway looks likely, given the current evidence. Therefore, we concluded that it appears likely that there is a link between several endocrine disorders and NAFLD other than the typically known type 2 diabetes mellitus and metabolic syndrome (MS). Nevertheless, there is controversial and insufficient evidence in this area of knowledge. |
format | Online Article Text |
id | pubmed-9026925 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90269252022-04-23 Nonalcoholic Fatty Liver Disease and Endocrine Axes—A Scoping Review Von-Hafe, Madalena Borges-Canha, Marta Vale, Catarina Leite, Ana Rita Sérgio Neves, João Carvalho, Davide Leite-Moreira, Adelino Metabolites Review Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease. NAFLD often occurs associated with endocrinopathies. Evidence suggests that endocrine dysfunction may play an important role in NAFLD development, progression, and severity. Our work aimed to explore and summarize the crosstalk between the liver and different endocrine organs, their hormones, and dysfunctions. For instance, our results show that hyperprolactinemia, hypercortisolemia, and polycystic ovary syndrome seem to worsen NAFLD’s pathway. Hypothyroidism and low growth hormone levels also may contribute to NAFLD’s progression, and a bidirectional association between hypercortisolism and hypogonadism and the NAFLD pathway looks likely, given the current evidence. Therefore, we concluded that it appears likely that there is a link between several endocrine disorders and NAFLD other than the typically known type 2 diabetes mellitus and metabolic syndrome (MS). Nevertheless, there is controversial and insufficient evidence in this area of knowledge. MDPI 2022-03-29 /pmc/articles/PMC9026925/ /pubmed/35448486 http://dx.doi.org/10.3390/metabo12040298 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Von-Hafe, Madalena Borges-Canha, Marta Vale, Catarina Leite, Ana Rita Sérgio Neves, João Carvalho, Davide Leite-Moreira, Adelino Nonalcoholic Fatty Liver Disease and Endocrine Axes—A Scoping Review |
title | Nonalcoholic Fatty Liver Disease and Endocrine Axes—A Scoping Review |
title_full | Nonalcoholic Fatty Liver Disease and Endocrine Axes—A Scoping Review |
title_fullStr | Nonalcoholic Fatty Liver Disease and Endocrine Axes—A Scoping Review |
title_full_unstemmed | Nonalcoholic Fatty Liver Disease and Endocrine Axes—A Scoping Review |
title_short | Nonalcoholic Fatty Liver Disease and Endocrine Axes—A Scoping Review |
title_sort | nonalcoholic fatty liver disease and endocrine axes—a scoping review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9026925/ https://www.ncbi.nlm.nih.gov/pubmed/35448486 http://dx.doi.org/10.3390/metabo12040298 |
work_keys_str_mv | AT vonhafemadalena nonalcoholicfattyliverdiseaseandendocrineaxesascopingreview AT borgescanhamarta nonalcoholicfattyliverdiseaseandendocrineaxesascopingreview AT valecatarina nonalcoholicfattyliverdiseaseandendocrineaxesascopingreview AT leiteanarita nonalcoholicfattyliverdiseaseandendocrineaxesascopingreview AT sergionevesjoao nonalcoholicfattyliverdiseaseandendocrineaxesascopingreview AT carvalhodavide nonalcoholicfattyliverdiseaseandendocrineaxesascopingreview AT leitemoreiraadelino nonalcoholicfattyliverdiseaseandendocrineaxesascopingreview |