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Nonalcoholic Fatty Liver Disease and Endocrine Axes—A Scoping Review

Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease. NAFLD often occurs associated with endocrinopathies. Evidence suggests that endocrine dysfunction may play an important role in NAFLD development, progression, and severity. Our work aimed to explore and summariz...

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Autores principales: Von-Hafe, Madalena, Borges-Canha, Marta, Vale, Catarina, Leite, Ana Rita, Sérgio Neves, João, Carvalho, Davide, Leite-Moreira, Adelino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9026925/
https://www.ncbi.nlm.nih.gov/pubmed/35448486
http://dx.doi.org/10.3390/metabo12040298
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author Von-Hafe, Madalena
Borges-Canha, Marta
Vale, Catarina
Leite, Ana Rita
Sérgio Neves, João
Carvalho, Davide
Leite-Moreira, Adelino
author_facet Von-Hafe, Madalena
Borges-Canha, Marta
Vale, Catarina
Leite, Ana Rita
Sérgio Neves, João
Carvalho, Davide
Leite-Moreira, Adelino
author_sort Von-Hafe, Madalena
collection PubMed
description Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease. NAFLD often occurs associated with endocrinopathies. Evidence suggests that endocrine dysfunction may play an important role in NAFLD development, progression, and severity. Our work aimed to explore and summarize the crosstalk between the liver and different endocrine organs, their hormones, and dysfunctions. For instance, our results show that hyperprolactinemia, hypercortisolemia, and polycystic ovary syndrome seem to worsen NAFLD’s pathway. Hypothyroidism and low growth hormone levels also may contribute to NAFLD’s progression, and a bidirectional association between hypercortisolism and hypogonadism and the NAFLD pathway looks likely, given the current evidence. Therefore, we concluded that it appears likely that there is a link between several endocrine disorders and NAFLD other than the typically known type 2 diabetes mellitus and metabolic syndrome (MS). Nevertheless, there is controversial and insufficient evidence in this area of knowledge.
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spelling pubmed-90269252022-04-23 Nonalcoholic Fatty Liver Disease and Endocrine Axes—A Scoping Review Von-Hafe, Madalena Borges-Canha, Marta Vale, Catarina Leite, Ana Rita Sérgio Neves, João Carvalho, Davide Leite-Moreira, Adelino Metabolites Review Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease. NAFLD often occurs associated with endocrinopathies. Evidence suggests that endocrine dysfunction may play an important role in NAFLD development, progression, and severity. Our work aimed to explore and summarize the crosstalk between the liver and different endocrine organs, their hormones, and dysfunctions. For instance, our results show that hyperprolactinemia, hypercortisolemia, and polycystic ovary syndrome seem to worsen NAFLD’s pathway. Hypothyroidism and low growth hormone levels also may contribute to NAFLD’s progression, and a bidirectional association between hypercortisolism and hypogonadism and the NAFLD pathway looks likely, given the current evidence. Therefore, we concluded that it appears likely that there is a link between several endocrine disorders and NAFLD other than the typically known type 2 diabetes mellitus and metabolic syndrome (MS). Nevertheless, there is controversial and insufficient evidence in this area of knowledge. MDPI 2022-03-29 /pmc/articles/PMC9026925/ /pubmed/35448486 http://dx.doi.org/10.3390/metabo12040298 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Von-Hafe, Madalena
Borges-Canha, Marta
Vale, Catarina
Leite, Ana Rita
Sérgio Neves, João
Carvalho, Davide
Leite-Moreira, Adelino
Nonalcoholic Fatty Liver Disease and Endocrine Axes—A Scoping Review
title Nonalcoholic Fatty Liver Disease and Endocrine Axes—A Scoping Review
title_full Nonalcoholic Fatty Liver Disease and Endocrine Axes—A Scoping Review
title_fullStr Nonalcoholic Fatty Liver Disease and Endocrine Axes—A Scoping Review
title_full_unstemmed Nonalcoholic Fatty Liver Disease and Endocrine Axes—A Scoping Review
title_short Nonalcoholic Fatty Liver Disease and Endocrine Axes—A Scoping Review
title_sort nonalcoholic fatty liver disease and endocrine axes—a scoping review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9026925/
https://www.ncbi.nlm.nih.gov/pubmed/35448486
http://dx.doi.org/10.3390/metabo12040298
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