Cargando…
Eye Movement Abnormalities in Amyotrophic Lateral Sclerosis
It is generally believed that eye movements are completely spared in amyotrophic lateral sclerosis (ALS). Although a series of eye movement abnormalities has been recognized in recent years, the findings are highly controversial, and bulbar disabilities should be considered in relation to eye moveme...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9026966/ https://www.ncbi.nlm.nih.gov/pubmed/35448020 http://dx.doi.org/10.3390/brainsci12040489 |
_version_ | 1784691243691802624 |
---|---|
author | Guo, Xintong Liu, Xiaoxuan Ye, Shan Liu, Xiangyi Yang, Xu Fan, Dongsheng |
author_facet | Guo, Xintong Liu, Xiaoxuan Ye, Shan Liu, Xiangyi Yang, Xu Fan, Dongsheng |
author_sort | Guo, Xintong |
collection | PubMed |
description | It is generally believed that eye movements are completely spared in amyotrophic lateral sclerosis (ALS). Although a series of eye movement abnormalities has been recognized in recent years, the findings are highly controversial, and bulbar disabilities should be considered in relation to eye movement abnormalities. The present study aimed to determine whether eye movement abnormalities are present in ALS and, if so, to investigate their characteristics and their association with bulbar disability in ALS patients. A total of 60 patients and 30 controls were recruited and underwent the standardized evaluations of the oculomotor system using videonystagmography. Square-wave jerks (OR: 16.20, 95% CI: 3.50–74.95, p < 0.001) and abnormal cogwheeling during smooth pursuit (OR: 14.04, 95% CI: 3.00–65.75, p = 0.001) were more frequently observed in ALS patients than in the control subjects. In subgroup analyses, square-wave jerks (OR: 26.51, 95% CI: 2.83–248.05, p = 0.004) and abnormal cogwheeling during smooth pursuit (OR: 6.56, 95% CI: 1.19–36.16, p = 0.031) were found to be more common in ALS patients with bulbar involvement (n = 44) than in those without bulbar involvement (n = 16). There were no significant differences in the investigated eye movement parameters between bulbar-onset (n = 12) and spinal-onset patients (n = 48). ALS patients showed a range of eye movement abnormalities, affecting mainly the ocular fixation and smooth pursuit systems. Our pioneering study indicates that the region of involvement could better indicate the pathophysiological essence of the abnormalities than the type of onset pattern in ALS. Eye movement abnormalities may be potential clinical markers for objectively evaluating upper brainstem or supratentorial cerebral lesion neurodegeneration in ALS. |
format | Online Article Text |
id | pubmed-9026966 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90269662022-04-23 Eye Movement Abnormalities in Amyotrophic Lateral Sclerosis Guo, Xintong Liu, Xiaoxuan Ye, Shan Liu, Xiangyi Yang, Xu Fan, Dongsheng Brain Sci Article It is generally believed that eye movements are completely spared in amyotrophic lateral sclerosis (ALS). Although a series of eye movement abnormalities has been recognized in recent years, the findings are highly controversial, and bulbar disabilities should be considered in relation to eye movement abnormalities. The present study aimed to determine whether eye movement abnormalities are present in ALS and, if so, to investigate their characteristics and their association with bulbar disability in ALS patients. A total of 60 patients and 30 controls were recruited and underwent the standardized evaluations of the oculomotor system using videonystagmography. Square-wave jerks (OR: 16.20, 95% CI: 3.50–74.95, p < 0.001) and abnormal cogwheeling during smooth pursuit (OR: 14.04, 95% CI: 3.00–65.75, p = 0.001) were more frequently observed in ALS patients than in the control subjects. In subgroup analyses, square-wave jerks (OR: 26.51, 95% CI: 2.83–248.05, p = 0.004) and abnormal cogwheeling during smooth pursuit (OR: 6.56, 95% CI: 1.19–36.16, p = 0.031) were found to be more common in ALS patients with bulbar involvement (n = 44) than in those without bulbar involvement (n = 16). There were no significant differences in the investigated eye movement parameters between bulbar-onset (n = 12) and spinal-onset patients (n = 48). ALS patients showed a range of eye movement abnormalities, affecting mainly the ocular fixation and smooth pursuit systems. Our pioneering study indicates that the region of involvement could better indicate the pathophysiological essence of the abnormalities than the type of onset pattern in ALS. Eye movement abnormalities may be potential clinical markers for objectively evaluating upper brainstem or supratentorial cerebral lesion neurodegeneration in ALS. MDPI 2022-04-11 /pmc/articles/PMC9026966/ /pubmed/35448020 http://dx.doi.org/10.3390/brainsci12040489 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Guo, Xintong Liu, Xiaoxuan Ye, Shan Liu, Xiangyi Yang, Xu Fan, Dongsheng Eye Movement Abnormalities in Amyotrophic Lateral Sclerosis |
title | Eye Movement Abnormalities in Amyotrophic Lateral Sclerosis |
title_full | Eye Movement Abnormalities in Amyotrophic Lateral Sclerosis |
title_fullStr | Eye Movement Abnormalities in Amyotrophic Lateral Sclerosis |
title_full_unstemmed | Eye Movement Abnormalities in Amyotrophic Lateral Sclerosis |
title_short | Eye Movement Abnormalities in Amyotrophic Lateral Sclerosis |
title_sort | eye movement abnormalities in amyotrophic lateral sclerosis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9026966/ https://www.ncbi.nlm.nih.gov/pubmed/35448020 http://dx.doi.org/10.3390/brainsci12040489 |
work_keys_str_mv | AT guoxintong eyemovementabnormalitiesinamyotrophiclateralsclerosis AT liuxiaoxuan eyemovementabnormalitiesinamyotrophiclateralsclerosis AT yeshan eyemovementabnormalitiesinamyotrophiclateralsclerosis AT liuxiangyi eyemovementabnormalitiesinamyotrophiclateralsclerosis AT yangxu eyemovementabnormalitiesinamyotrophiclateralsclerosis AT fandongsheng eyemovementabnormalitiesinamyotrophiclateralsclerosis |