Cargando…

Eye Movement Abnormalities in Amyotrophic Lateral Sclerosis

It is generally believed that eye movements are completely spared in amyotrophic lateral sclerosis (ALS). Although a series of eye movement abnormalities has been recognized in recent years, the findings are highly controversial, and bulbar disabilities should be considered in relation to eye moveme...

Descripción completa

Detalles Bibliográficos
Autores principales: Guo, Xintong, Liu, Xiaoxuan, Ye, Shan, Liu, Xiangyi, Yang, Xu, Fan, Dongsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9026966/
https://www.ncbi.nlm.nih.gov/pubmed/35448020
http://dx.doi.org/10.3390/brainsci12040489
_version_ 1784691243691802624
author Guo, Xintong
Liu, Xiaoxuan
Ye, Shan
Liu, Xiangyi
Yang, Xu
Fan, Dongsheng
author_facet Guo, Xintong
Liu, Xiaoxuan
Ye, Shan
Liu, Xiangyi
Yang, Xu
Fan, Dongsheng
author_sort Guo, Xintong
collection PubMed
description It is generally believed that eye movements are completely spared in amyotrophic lateral sclerosis (ALS). Although a series of eye movement abnormalities has been recognized in recent years, the findings are highly controversial, and bulbar disabilities should be considered in relation to eye movement abnormalities. The present study aimed to determine whether eye movement abnormalities are present in ALS and, if so, to investigate their characteristics and their association with bulbar disability in ALS patients. A total of 60 patients and 30 controls were recruited and underwent the standardized evaluations of the oculomotor system using videonystagmography. Square-wave jerks (OR: 16.20, 95% CI: 3.50–74.95, p < 0.001) and abnormal cogwheeling during smooth pursuit (OR: 14.04, 95% CI: 3.00–65.75, p = 0.001) were more frequently observed in ALS patients than in the control subjects. In subgroup analyses, square-wave jerks (OR: 26.51, 95% CI: 2.83–248.05, p = 0.004) and abnormal cogwheeling during smooth pursuit (OR: 6.56, 95% CI: 1.19–36.16, p = 0.031) were found to be more common in ALS patients with bulbar involvement (n = 44) than in those without bulbar involvement (n = 16). There were no significant differences in the investigated eye movement parameters between bulbar-onset (n = 12) and spinal-onset patients (n = 48). ALS patients showed a range of eye movement abnormalities, affecting mainly the ocular fixation and smooth pursuit systems. Our pioneering study indicates that the region of involvement could better indicate the pathophysiological essence of the abnormalities than the type of onset pattern in ALS. Eye movement abnormalities may be potential clinical markers for objectively evaluating upper brainstem or supratentorial cerebral lesion neurodegeneration in ALS.
format Online
Article
Text
id pubmed-9026966
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-90269662022-04-23 Eye Movement Abnormalities in Amyotrophic Lateral Sclerosis Guo, Xintong Liu, Xiaoxuan Ye, Shan Liu, Xiangyi Yang, Xu Fan, Dongsheng Brain Sci Article It is generally believed that eye movements are completely spared in amyotrophic lateral sclerosis (ALS). Although a series of eye movement abnormalities has been recognized in recent years, the findings are highly controversial, and bulbar disabilities should be considered in relation to eye movement abnormalities. The present study aimed to determine whether eye movement abnormalities are present in ALS and, if so, to investigate their characteristics and their association with bulbar disability in ALS patients. A total of 60 patients and 30 controls were recruited and underwent the standardized evaluations of the oculomotor system using videonystagmography. Square-wave jerks (OR: 16.20, 95% CI: 3.50–74.95, p < 0.001) and abnormal cogwheeling during smooth pursuit (OR: 14.04, 95% CI: 3.00–65.75, p = 0.001) were more frequently observed in ALS patients than in the control subjects. In subgroup analyses, square-wave jerks (OR: 26.51, 95% CI: 2.83–248.05, p = 0.004) and abnormal cogwheeling during smooth pursuit (OR: 6.56, 95% CI: 1.19–36.16, p = 0.031) were found to be more common in ALS patients with bulbar involvement (n = 44) than in those without bulbar involvement (n = 16). There were no significant differences in the investigated eye movement parameters between bulbar-onset (n = 12) and spinal-onset patients (n = 48). ALS patients showed a range of eye movement abnormalities, affecting mainly the ocular fixation and smooth pursuit systems. Our pioneering study indicates that the region of involvement could better indicate the pathophysiological essence of the abnormalities than the type of onset pattern in ALS. Eye movement abnormalities may be potential clinical markers for objectively evaluating upper brainstem or supratentorial cerebral lesion neurodegeneration in ALS. MDPI 2022-04-11 /pmc/articles/PMC9026966/ /pubmed/35448020 http://dx.doi.org/10.3390/brainsci12040489 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Guo, Xintong
Liu, Xiaoxuan
Ye, Shan
Liu, Xiangyi
Yang, Xu
Fan, Dongsheng
Eye Movement Abnormalities in Amyotrophic Lateral Sclerosis
title Eye Movement Abnormalities in Amyotrophic Lateral Sclerosis
title_full Eye Movement Abnormalities in Amyotrophic Lateral Sclerosis
title_fullStr Eye Movement Abnormalities in Amyotrophic Lateral Sclerosis
title_full_unstemmed Eye Movement Abnormalities in Amyotrophic Lateral Sclerosis
title_short Eye Movement Abnormalities in Amyotrophic Lateral Sclerosis
title_sort eye movement abnormalities in amyotrophic lateral sclerosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9026966/
https://www.ncbi.nlm.nih.gov/pubmed/35448020
http://dx.doi.org/10.3390/brainsci12040489
work_keys_str_mv AT guoxintong eyemovementabnormalitiesinamyotrophiclateralsclerosis
AT liuxiaoxuan eyemovementabnormalitiesinamyotrophiclateralsclerosis
AT yeshan eyemovementabnormalitiesinamyotrophiclateralsclerosis
AT liuxiangyi eyemovementabnormalitiesinamyotrophiclateralsclerosis
AT yangxu eyemovementabnormalitiesinamyotrophiclateralsclerosis
AT fandongsheng eyemovementabnormalitiesinamyotrophiclateralsclerosis