Mechanochemical Dimerization of Aldoximes to Furoxans

Solvent-free mechanical milling is a new, environmentally friendly and cost-effective technology that is now widely used in the field of organic synthesis. The mechanochemical solvent-free synthesis of furoxans from aldoximes was achieved through dimerization of the in situ generated nitrile oxides...

Descripción completa

Detalles Bibliográficos
Autores principales: Fang, Run-Kai, Chen, Kuan, Niu, Chuang, Wang, Guan-Wu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027020/
https://www.ncbi.nlm.nih.gov/pubmed/35458802
http://dx.doi.org/10.3390/molecules27082604
_version_ 1784691255950704640
author Fang, Run-Kai
Chen, Kuan
Niu, Chuang
Wang, Guan-Wu
author_facet Fang, Run-Kai
Chen, Kuan
Niu, Chuang
Wang, Guan-Wu
author_sort Fang, Run-Kai
collection PubMed
description Solvent-free mechanical milling is a new, environmentally friendly and cost-effective technology that is now widely used in the field of organic synthesis. The mechanochemical solvent-free synthesis of furoxans from aldoximes was achieved through dimerization of the in situ generated nitrile oxides in the presence of sodium chloride, Oxone and a base. A variety of furoxans was obtained with up to a 92% yield. The present protocol has the advantages of high reaction efficiency and mild reaction conditions.
format Online
Article
Text
id pubmed-9027020
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-90270202022-04-23 Mechanochemical Dimerization of Aldoximes to Furoxans Fang, Run-Kai Chen, Kuan Niu, Chuang Wang, Guan-Wu Molecules Article Solvent-free mechanical milling is a new, environmentally friendly and cost-effective technology that is now widely used in the field of organic synthesis. The mechanochemical solvent-free synthesis of furoxans from aldoximes was achieved through dimerization of the in situ generated nitrile oxides in the presence of sodium chloride, Oxone and a base. A variety of furoxans was obtained with up to a 92% yield. The present protocol has the advantages of high reaction efficiency and mild reaction conditions. MDPI 2022-04-18 /pmc/articles/PMC9027020/ /pubmed/35458802 http://dx.doi.org/10.3390/molecules27082604 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fang, Run-Kai
Chen, Kuan
Niu, Chuang
Wang, Guan-Wu
Mechanochemical Dimerization of Aldoximes to Furoxans
title Mechanochemical Dimerization of Aldoximes to Furoxans
title_full Mechanochemical Dimerization of Aldoximes to Furoxans
title_fullStr Mechanochemical Dimerization of Aldoximes to Furoxans
title_full_unstemmed Mechanochemical Dimerization of Aldoximes to Furoxans
title_short Mechanochemical Dimerization of Aldoximes to Furoxans
title_sort mechanochemical dimerization of aldoximes to furoxans
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027020/
https://www.ncbi.nlm.nih.gov/pubmed/35458802
http://dx.doi.org/10.3390/molecules27082604
work_keys_str_mv AT fangrunkai mechanochemicaldimerizationofaldoximestofuroxans
AT chenkuan mechanochemicaldimerizationofaldoximestofuroxans
AT niuchuang mechanochemicaldimerizationofaldoximestofuroxans
AT wangguanwu mechanochemicaldimerizationofaldoximestofuroxans

Ejemplares similares