CDK6-PI3K signaling axis is an efficient target for attenuating ABCB1/P-gp mediated multi-drug resistance (MDR) in cancer cells

BACKGROUND: Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1/P-gp) is a major cause of cancer chemotherapy failure, but the regulation mechanisms are largely unknown. METHODS: Based on single gene knockout, we studied the regulation of CDK6-PI3K axis on ABCB1-m...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Lei, Li, Yidong, Hu, Chaohua, Chen, Yangmin, Chen, Zhuo, Chen, Zhe-Sheng, Zhang, Jian-Ye, Fang, Shuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027122/
https://www.ncbi.nlm.nih.gov/pubmed/35459184
http://dx.doi.org/10.1186/s12943-022-01524-w

Ejemplares similares

Ejemplares similares