Crystal structure of SARS-CoV 3C-like protease with baicalein

The 3C-like protease (M(pro), 3CL(pro)) plays a key role in the replication process in coronaviruses (CoVs). The M(pro) is an essential enzyme mediates CoVs replication and is a promising target for development of antiviral drugs. Until now, baicalein has been shown the specific activity for SARS-Co...

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Detalles Bibliográficos
Autores principales: Feng, Jingwen, Li, Dongyang, Zhang, Jin, Yin, Xiushan, Li, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027212/
https://www.ncbi.nlm.nih.gov/pubmed/35490659
http://dx.doi.org/10.1016/j.bbrc.2022.04.086
Descripción
Sumario:The 3C-like protease (M(pro), 3CL(pro)) plays a key role in the replication process in coronaviruses (CoVs). The M(pro) is an essential enzyme mediates CoVs replication and is a promising target for development of antiviral drugs. Until now, baicalein has been shown the specific activity for SARS-CoV M(pro) in vitro experiments. In this study, we resolved the SARS-CoV M(pro) with baicalein by X-ray diffraction at 2.25 Å (PDB code 7XAX), which provided a structural basis for the research and development of baicalein as an anti-CoVs drug.

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