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Implementing a Personalized Antimicrobial Stewardship Program for Women with Gynecological Cancers and Healthcare-Associated Infections

Healthcare-associated infections (HCAIs) represent a major cause of morbidity and mortality in gynecologic cancer patients, requiring personalized cures. A retrospective study on gynecologic patients with HCAIs, managed through an antimicrobial stewardship program, was performed, focusing on rates o...

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Autores principales: Di Giambenedetto, Simona, Borghetti, Alberto, Quagliozzi, Lorena, Gallucci, Valeria, Lombardi, Francesca, Ciccullo, Arturo, Fagotti, Anna, Tamburrini, Enrica, Scambia, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027292/
https://www.ncbi.nlm.nih.gov/pubmed/35455766
http://dx.doi.org/10.3390/jpm12040650
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author Di Giambenedetto, Simona
Borghetti, Alberto
Quagliozzi, Lorena
Gallucci, Valeria
Lombardi, Francesca
Ciccullo, Arturo
Fagotti, Anna
Tamburrini, Enrica
Scambia, Giovanni
author_facet Di Giambenedetto, Simona
Borghetti, Alberto
Quagliozzi, Lorena
Gallucci, Valeria
Lombardi, Francesca
Ciccullo, Arturo
Fagotti, Anna
Tamburrini, Enrica
Scambia, Giovanni
author_sort Di Giambenedetto, Simona
collection PubMed
description Healthcare-associated infections (HCAIs) represent a major cause of morbidity and mortality in gynecologic cancer patients, requiring personalized cures. A retrospective study on gynecologic patients with HCAIs, managed through an antimicrobial stewardship program, was performed, focusing on rates of clinical cure, breakthrough/relapse of infections, death, and time of hospital stay (THS). In total, 27 patients (median 60 years, mainly suffering from ovarian, cervical, and uterine cancer) were evaluated by a specialist in infectious diseases and were mainly diagnosed with complicated urinary tract (cUTIs, 12 cases, 44.4%) and bloodstream infections (BSIs, 9 cases, 33.3%). A total of 15 cases (11 cUTIs, 73.3%) were managed with no need for hospitalization and received a median of 11 days of outpatient parenteral antimicrobial therapy (OPAT). In the remaining 12 cases (BSIs in 8 cases, 66.7%), the median THS was 11 days, with 15 days median overall duration of antimicrobial therapy (median 5-day reduction in THS). The management of patients also included source control and wound care. All patients reached clinical cure, with no case of breakthrough infection, one case of relapse, and one death within 30 days (not attributable to the infection). HCAIs in patients with gynecologic tumors can be managed through a patient-centered, multidisciplinary antimicrobial stewardship program.
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spelling pubmed-90272922022-04-23 Implementing a Personalized Antimicrobial Stewardship Program for Women with Gynecological Cancers and Healthcare-Associated Infections Di Giambenedetto, Simona Borghetti, Alberto Quagliozzi, Lorena Gallucci, Valeria Lombardi, Francesca Ciccullo, Arturo Fagotti, Anna Tamburrini, Enrica Scambia, Giovanni J Pers Med Communication Healthcare-associated infections (HCAIs) represent a major cause of morbidity and mortality in gynecologic cancer patients, requiring personalized cures. A retrospective study on gynecologic patients with HCAIs, managed through an antimicrobial stewardship program, was performed, focusing on rates of clinical cure, breakthrough/relapse of infections, death, and time of hospital stay (THS). In total, 27 patients (median 60 years, mainly suffering from ovarian, cervical, and uterine cancer) were evaluated by a specialist in infectious diseases and were mainly diagnosed with complicated urinary tract (cUTIs, 12 cases, 44.4%) and bloodstream infections (BSIs, 9 cases, 33.3%). A total of 15 cases (11 cUTIs, 73.3%) were managed with no need for hospitalization and received a median of 11 days of outpatient parenteral antimicrobial therapy (OPAT). In the remaining 12 cases (BSIs in 8 cases, 66.7%), the median THS was 11 days, with 15 days median overall duration of antimicrobial therapy (median 5-day reduction in THS). The management of patients also included source control and wound care. All patients reached clinical cure, with no case of breakthrough infection, one case of relapse, and one death within 30 days (not attributable to the infection). HCAIs in patients with gynecologic tumors can be managed through a patient-centered, multidisciplinary antimicrobial stewardship program. MDPI 2022-04-18 /pmc/articles/PMC9027292/ /pubmed/35455766 http://dx.doi.org/10.3390/jpm12040650 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Di Giambenedetto, Simona
Borghetti, Alberto
Quagliozzi, Lorena
Gallucci, Valeria
Lombardi, Francesca
Ciccullo, Arturo
Fagotti, Anna
Tamburrini, Enrica
Scambia, Giovanni
Implementing a Personalized Antimicrobial Stewardship Program for Women with Gynecological Cancers and Healthcare-Associated Infections
title Implementing a Personalized Antimicrobial Stewardship Program for Women with Gynecological Cancers and Healthcare-Associated Infections
title_full Implementing a Personalized Antimicrobial Stewardship Program for Women with Gynecological Cancers and Healthcare-Associated Infections
title_fullStr Implementing a Personalized Antimicrobial Stewardship Program for Women with Gynecological Cancers and Healthcare-Associated Infections
title_full_unstemmed Implementing a Personalized Antimicrobial Stewardship Program for Women with Gynecological Cancers and Healthcare-Associated Infections
title_short Implementing a Personalized Antimicrobial Stewardship Program for Women with Gynecological Cancers and Healthcare-Associated Infections
title_sort implementing a personalized antimicrobial stewardship program for women with gynecological cancers and healthcare-associated infections
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027292/
https://www.ncbi.nlm.nih.gov/pubmed/35455766
http://dx.doi.org/10.3390/jpm12040650
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