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What is related to postoperative outcome of frail status in elective colorectal cancer surgery?

BACKGROUND: The population affected by colorectal cancer is growing, and there is an increasing need for prevention of functional decline following treatment. We proposed that the Kihon Checklist published by the Japanese Ministry of Health, Labor, and Welfare would be an appropriate means of frailt...

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Autores principales: Tamura, Koichi, Matsuda, Kenji, Fujita, Yoichi, Sakaguchi, Satoru, Kinoshita, Hiroyuki, Yamade, Naohisa, Hotta, Tsukasa, Iwamoto, Hiromitsu, Mizumoto, Yuki, Yamaue, Hiroki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027309/
https://www.ncbi.nlm.nih.gov/pubmed/35463847
http://dx.doi.org/10.1016/j.sopen.2022.03.004
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author Tamura, Koichi
Matsuda, Kenji
Fujita, Yoichi
Sakaguchi, Satoru
Kinoshita, Hiroyuki
Yamade, Naohisa
Hotta, Tsukasa
Iwamoto, Hiromitsu
Mizumoto, Yuki
Yamaue, Hiroki
author_facet Tamura, Koichi
Matsuda, Kenji
Fujita, Yoichi
Sakaguchi, Satoru
Kinoshita, Hiroyuki
Yamade, Naohisa
Hotta, Tsukasa
Iwamoto, Hiromitsu
Mizumoto, Yuki
Yamaue, Hiroki
author_sort Tamura, Koichi
collection PubMed
description BACKGROUND: The population affected by colorectal cancer is growing, and there is an increasing need for prevention of functional decline following treatment. We proposed that the Kihon Checklist published by the Japanese Ministry of Health, Labor, and Welfare would be an appropriate means of frailty assessment for prediction of postoperative complications in older patients with colorectal cancer. This prospective cohort study aims to identify the factors influencing postoperative frailty. METHODS: We prospectively enrolled consecutive patients with colorectal cancer and aged ≥ 65 year (N = 500) between May 2017 and December 2018. Eligible patients were assessed with the Kihon Checklist prior to surgery and 30 days after surgery. The main measures were variables related to postoperative change in view of frail status. RESULTS: According to the Kihon Checklist questionnaire, 164 patients were frail preoperatively and 172 patients were frail postoperatively, whereas 38 patients changed from "nonfrail" before surgery to postoperative "frail." Overall complications were counted in 97 patients (19.4%), and 5 patients died. Performance status ≥ 2, history of laparotomy, open surgery, complication, ostomy creation, and delirium were significantly associated with changing postoperative "frail" (P = .014, P = .023, P = .006, P < .001, P = .023, and P = .024, respectively). In multivariate analysis, independent related factors of changing postoperative "frail" were complication (odds ratio 2.69, 95% confidence interval 1.19–6.09, P = .018) and ostomy creation (odds ratio 2.32, 95% confidence interval 1.01–5.33, P = .047). CONCLUSION: The Kihon Checklist questionnaire could identify the factors related to postoperative change of frailty status in older patients with colorectal cancer. This cohort concluded that whether postoperative complication occurred or not was closely associated with perioperative change of frailty status.
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spelling pubmed-90273092022-04-23 What is related to postoperative outcome of frail status in elective colorectal cancer surgery? Tamura, Koichi Matsuda, Kenji Fujita, Yoichi Sakaguchi, Satoru Kinoshita, Hiroyuki Yamade, Naohisa Hotta, Tsukasa Iwamoto, Hiromitsu Mizumoto, Yuki Yamaue, Hiroki Surg Open Sci Research Article BACKGROUND: The population affected by colorectal cancer is growing, and there is an increasing need for prevention of functional decline following treatment. We proposed that the Kihon Checklist published by the Japanese Ministry of Health, Labor, and Welfare would be an appropriate means of frailty assessment for prediction of postoperative complications in older patients with colorectal cancer. This prospective cohort study aims to identify the factors influencing postoperative frailty. METHODS: We prospectively enrolled consecutive patients with colorectal cancer and aged ≥ 65 year (N = 500) between May 2017 and December 2018. Eligible patients were assessed with the Kihon Checklist prior to surgery and 30 days after surgery. The main measures were variables related to postoperative change in view of frail status. RESULTS: According to the Kihon Checklist questionnaire, 164 patients were frail preoperatively and 172 patients were frail postoperatively, whereas 38 patients changed from "nonfrail" before surgery to postoperative "frail." Overall complications were counted in 97 patients (19.4%), and 5 patients died. Performance status ≥ 2, history of laparotomy, open surgery, complication, ostomy creation, and delirium were significantly associated with changing postoperative "frail" (P = .014, P = .023, P = .006, P < .001, P = .023, and P = .024, respectively). In multivariate analysis, independent related factors of changing postoperative "frail" were complication (odds ratio 2.69, 95% confidence interval 1.19–6.09, P = .018) and ostomy creation (odds ratio 2.32, 95% confidence interval 1.01–5.33, P = .047). CONCLUSION: The Kihon Checklist questionnaire could identify the factors related to postoperative change of frailty status in older patients with colorectal cancer. This cohort concluded that whether postoperative complication occurred or not was closely associated with perioperative change of frailty status. Elsevier 2022-03-23 /pmc/articles/PMC9027309/ /pubmed/35463847 http://dx.doi.org/10.1016/j.sopen.2022.03.004 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Tamura, Koichi
Matsuda, Kenji
Fujita, Yoichi
Sakaguchi, Satoru
Kinoshita, Hiroyuki
Yamade, Naohisa
Hotta, Tsukasa
Iwamoto, Hiromitsu
Mizumoto, Yuki
Yamaue, Hiroki
What is related to postoperative outcome of frail status in elective colorectal cancer surgery?
title What is related to postoperative outcome of frail status in elective colorectal cancer surgery?
title_full What is related to postoperative outcome of frail status in elective colorectal cancer surgery?
title_fullStr What is related to postoperative outcome of frail status in elective colorectal cancer surgery?
title_full_unstemmed What is related to postoperative outcome of frail status in elective colorectal cancer surgery?
title_short What is related to postoperative outcome of frail status in elective colorectal cancer surgery?
title_sort what is related to postoperative outcome of frail status in elective colorectal cancer surgery?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027309/
https://www.ncbi.nlm.nih.gov/pubmed/35463847
http://dx.doi.org/10.1016/j.sopen.2022.03.004
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