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Updated Review of the Evidence Supporting the Medical and Legal Use of NeuroQuant(®) and NeuroGage(®) in Patients With Traumatic Brain Injury

Over 40 years of research have shown that traumatic brain injury affects brain volume. However, technical and practical limitations made it difficult to detect brain volume abnormalities in patients suffering from chronic effects of mild or moderate traumatic brain injury. This situation improved in...

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Autores principales: Ross, David E., Seabaugh, John, Seabaugh, Jan M., Barcelona, Justis, Seabaugh, Daniel, Wright, Katherine, Norwind, Lee, King, Zachary, Graham, Travis J., Baker, Joseph, Lewis, Tanner
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027332/
https://www.ncbi.nlm.nih.gov/pubmed/35463926
http://dx.doi.org/10.3389/fnhum.2022.715807
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author Ross, David E.
Seabaugh, John
Seabaugh, Jan M.
Barcelona, Justis
Seabaugh, Daniel
Wright, Katherine
Norwind, Lee
King, Zachary
Graham, Travis J.
Baker, Joseph
Lewis, Tanner
author_facet Ross, David E.
Seabaugh, John
Seabaugh, Jan M.
Barcelona, Justis
Seabaugh, Daniel
Wright, Katherine
Norwind, Lee
King, Zachary
Graham, Travis J.
Baker, Joseph
Lewis, Tanner
author_sort Ross, David E.
collection PubMed
description Over 40 years of research have shown that traumatic brain injury affects brain volume. However, technical and practical limitations made it difficult to detect brain volume abnormalities in patients suffering from chronic effects of mild or moderate traumatic brain injury. This situation improved in 2006 with the FDA clearance of NeuroQuant(®), a commercially available, computer-automated software program for measuring MRI brain volume in human subjects. More recent strides were made with the introduction of NeuroGage(®), commercially available software that is based on NeuroQuant(®) and extends its utility in several ways. Studies using these and similar methods have found that most patients with chronic mild or moderate traumatic brain injury have brain volume abnormalities, and several of these studies found—surprisingly—more abnormal enlargement than atrophy. More generally, 102 peer-reviewed studies have supported the reliability and validity of NeuroQuant(®) and NeuroGage(®). Furthermore, this updated version of a previous review addresses whether NeuroQuant(®) and NeuroGage(®) meet the Daubert standard for admissibility in court. It concludes that NeuroQuant(®) and NeuroGage(®) meet the Daubert standard based on their reliability, validity, and objectivity. Due to the improvements in technology over the years, these brain volumetric techniques are practical and readily available for clinical or forensic use, and thus they are important tools for detecting signs of brain injury.
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spelling pubmed-90273322022-04-23 Updated Review of the Evidence Supporting the Medical and Legal Use of NeuroQuant(®) and NeuroGage(®) in Patients With Traumatic Brain Injury Ross, David E. Seabaugh, John Seabaugh, Jan M. Barcelona, Justis Seabaugh, Daniel Wright, Katherine Norwind, Lee King, Zachary Graham, Travis J. Baker, Joseph Lewis, Tanner Front Hum Neurosci Neuroscience Over 40 years of research have shown that traumatic brain injury affects brain volume. However, technical and practical limitations made it difficult to detect brain volume abnormalities in patients suffering from chronic effects of mild or moderate traumatic brain injury. This situation improved in 2006 with the FDA clearance of NeuroQuant(®), a commercially available, computer-automated software program for measuring MRI brain volume in human subjects. More recent strides were made with the introduction of NeuroGage(®), commercially available software that is based on NeuroQuant(®) and extends its utility in several ways. Studies using these and similar methods have found that most patients with chronic mild or moderate traumatic brain injury have brain volume abnormalities, and several of these studies found—surprisingly—more abnormal enlargement than atrophy. More generally, 102 peer-reviewed studies have supported the reliability and validity of NeuroQuant(®) and NeuroGage(®). Furthermore, this updated version of a previous review addresses whether NeuroQuant(®) and NeuroGage(®) meet the Daubert standard for admissibility in court. It concludes that NeuroQuant(®) and NeuroGage(®) meet the Daubert standard based on their reliability, validity, and objectivity. Due to the improvements in technology over the years, these brain volumetric techniques are practical and readily available for clinical or forensic use, and thus they are important tools for detecting signs of brain injury. Frontiers Media S.A. 2022-04-08 /pmc/articles/PMC9027332/ /pubmed/35463926 http://dx.doi.org/10.3389/fnhum.2022.715807 Text en Copyright © 2022 Ross, Seabaugh, Seabaugh, Barcelona, Seabaugh, Wright, Norwind, King, Graham, Baker and Lewis. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Ross, David E.
Seabaugh, John
Seabaugh, Jan M.
Barcelona, Justis
Seabaugh, Daniel
Wright, Katherine
Norwind, Lee
King, Zachary
Graham, Travis J.
Baker, Joseph
Lewis, Tanner
Updated Review of the Evidence Supporting the Medical and Legal Use of NeuroQuant(®) and NeuroGage(®) in Patients With Traumatic Brain Injury
title Updated Review of the Evidence Supporting the Medical and Legal Use of NeuroQuant(®) and NeuroGage(®) in Patients With Traumatic Brain Injury
title_full Updated Review of the Evidence Supporting the Medical and Legal Use of NeuroQuant(®) and NeuroGage(®) in Patients With Traumatic Brain Injury
title_fullStr Updated Review of the Evidence Supporting the Medical and Legal Use of NeuroQuant(®) and NeuroGage(®) in Patients With Traumatic Brain Injury
title_full_unstemmed Updated Review of the Evidence Supporting the Medical and Legal Use of NeuroQuant(®) and NeuroGage(®) in Patients With Traumatic Brain Injury
title_short Updated Review of the Evidence Supporting the Medical and Legal Use of NeuroQuant(®) and NeuroGage(®) in Patients With Traumatic Brain Injury
title_sort updated review of the evidence supporting the medical and legal use of neuroquant(®) and neurogage(®) in patients with traumatic brain injury
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027332/
https://www.ncbi.nlm.nih.gov/pubmed/35463926
http://dx.doi.org/10.3389/fnhum.2022.715807
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