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The Relaxin-3 Receptor, RXFP3, Is a Modulator of Aging-Related Disease
During the aging process our body becomes less well equipped to deal with cellular stress, resulting in an increase in unrepaired damage. This causes varying degrees of impaired functionality and an increased risk of mortality. One of the most effective anti-aging strategies involves interventions t...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027355/ https://www.ncbi.nlm.nih.gov/pubmed/35457203 http://dx.doi.org/10.3390/ijms23084387 |
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author | Leysen, Hanne Walter, Deborah Clauwaert, Lore Hellemans, Lieselot van Gastel, Jaana Vasudevan, Lakshmi Martin, Bronwen Maudsley, Stuart |
author_facet | Leysen, Hanne Walter, Deborah Clauwaert, Lore Hellemans, Lieselot van Gastel, Jaana Vasudevan, Lakshmi Martin, Bronwen Maudsley, Stuart |
author_sort | Leysen, Hanne |
collection | PubMed |
description | During the aging process our body becomes less well equipped to deal with cellular stress, resulting in an increase in unrepaired damage. This causes varying degrees of impaired functionality and an increased risk of mortality. One of the most effective anti-aging strategies involves interventions that combine simultaneous glucometabolic support with augmented DNA damage protection/repair. Thus, it seems prudent to develop therapeutic strategies that target this combinatorial approach. Studies have shown that the ADP-ribosylation factor (ARF) GTPase activating protein GIT2 (GIT2) acts as a keystone protein in the aging process. GIT2 can control both DNA repair and glucose metabolism. Through in vivo co-regulation analyses it was found that GIT2 forms a close coexpression-based relationship with the relaxin-3 receptor (RXFP3). Cellular RXFP3 expression is directly affected by DNA damage and oxidative stress. Overexpression or stimulation of this receptor, by its endogenous ligand relaxin 3 (RLN3), can regulate the DNA damage response and repair processes. Interestingly, RLN3 is an insulin-like peptide and has been shown to control multiple disease processes linked to aging mechanisms, e.g., anxiety, depression, memory dysfunction, appetite, and anti-apoptotic mechanisms. Here we discuss the molecular mechanisms underlying the various roles of RXFP3/RLN3 signaling in aging and age-related disorders. |
format | Online Article Text |
id | pubmed-9027355 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90273552022-04-23 The Relaxin-3 Receptor, RXFP3, Is a Modulator of Aging-Related Disease Leysen, Hanne Walter, Deborah Clauwaert, Lore Hellemans, Lieselot van Gastel, Jaana Vasudevan, Lakshmi Martin, Bronwen Maudsley, Stuart Int J Mol Sci Review During the aging process our body becomes less well equipped to deal with cellular stress, resulting in an increase in unrepaired damage. This causes varying degrees of impaired functionality and an increased risk of mortality. One of the most effective anti-aging strategies involves interventions that combine simultaneous glucometabolic support with augmented DNA damage protection/repair. Thus, it seems prudent to develop therapeutic strategies that target this combinatorial approach. Studies have shown that the ADP-ribosylation factor (ARF) GTPase activating protein GIT2 (GIT2) acts as a keystone protein in the aging process. GIT2 can control both DNA repair and glucose metabolism. Through in vivo co-regulation analyses it was found that GIT2 forms a close coexpression-based relationship with the relaxin-3 receptor (RXFP3). Cellular RXFP3 expression is directly affected by DNA damage and oxidative stress. Overexpression or stimulation of this receptor, by its endogenous ligand relaxin 3 (RLN3), can regulate the DNA damage response and repair processes. Interestingly, RLN3 is an insulin-like peptide and has been shown to control multiple disease processes linked to aging mechanisms, e.g., anxiety, depression, memory dysfunction, appetite, and anti-apoptotic mechanisms. Here we discuss the molecular mechanisms underlying the various roles of RXFP3/RLN3 signaling in aging and age-related disorders. MDPI 2022-04-15 /pmc/articles/PMC9027355/ /pubmed/35457203 http://dx.doi.org/10.3390/ijms23084387 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Leysen, Hanne Walter, Deborah Clauwaert, Lore Hellemans, Lieselot van Gastel, Jaana Vasudevan, Lakshmi Martin, Bronwen Maudsley, Stuart The Relaxin-3 Receptor, RXFP3, Is a Modulator of Aging-Related Disease |
title | The Relaxin-3 Receptor, RXFP3, Is a Modulator of Aging-Related Disease |
title_full | The Relaxin-3 Receptor, RXFP3, Is a Modulator of Aging-Related Disease |
title_fullStr | The Relaxin-3 Receptor, RXFP3, Is a Modulator of Aging-Related Disease |
title_full_unstemmed | The Relaxin-3 Receptor, RXFP3, Is a Modulator of Aging-Related Disease |
title_short | The Relaxin-3 Receptor, RXFP3, Is a Modulator of Aging-Related Disease |
title_sort | relaxin-3 receptor, rxfp3, is a modulator of aging-related disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027355/ https://www.ncbi.nlm.nih.gov/pubmed/35457203 http://dx.doi.org/10.3390/ijms23084387 |
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