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Methylenetetrahydrofolate Reductase Polymorphism (rs1801133) and the Risk of Hypertension among African Populations: A Narrative Synthesis of Literature

In this review, we have gathered and analyzed the available genetic evidence on the association between the methylenetetrahydrofolate reductase gene (MTHFR), rs1801133 and the risk of Hypertension (HTN) in African populations, which was further compared to the global data evidence. This review was r...

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Autores principales: Mabhida, Sihle E., Muhamed, Babu, Sharma, Jyoti R., Apalata, Teke, Nomatshila, Sibusiso, Mabasa, Lawrence, Benjeddou, Mongi, Masilela, Charity, Ziqubu, Khanyisani, Shabalala, Samukelisiwe, Johnson, Rabia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027465/
https://www.ncbi.nlm.nih.gov/pubmed/35456437
http://dx.doi.org/10.3390/genes13040631
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author Mabhida, Sihle E.
Muhamed, Babu
Sharma, Jyoti R.
Apalata, Teke
Nomatshila, Sibusiso
Mabasa, Lawrence
Benjeddou, Mongi
Masilela, Charity
Ziqubu, Khanyisani
Shabalala, Samukelisiwe
Johnson, Rabia
author_facet Mabhida, Sihle E.
Muhamed, Babu
Sharma, Jyoti R.
Apalata, Teke
Nomatshila, Sibusiso
Mabasa, Lawrence
Benjeddou, Mongi
Masilela, Charity
Ziqubu, Khanyisani
Shabalala, Samukelisiwe
Johnson, Rabia
author_sort Mabhida, Sihle E.
collection PubMed
description In this review, we have gathered and analyzed the available genetic evidence on the association between the methylenetetrahydrofolate reductase gene (MTHFR), rs1801133 and the risk of Hypertension (HTN) in African populations, which was further compared to the global data evidence. This review was reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol and Human Genome Epidemiology Network (HuGENet) guidelines. Literature was retrieved through major search databases, including PubMed, Scopus, Web of Science, and African Journal Online. We identified 64 potential studies, of which 4 studies were from the African continent and 60 studies were reported globally. Among the studies conducted in Africa, only two (n = 2) reported a significant association between the MTHFR (rs1801133) and the risk of developing HTN. Only one (n = 1) study population was purely composed of black Africans, while others were of other ethnicities. Among studies conducted in other continents (n = 60), forty-seven (n = 47) studies reported a positive association between MTHFR (rs1801133) and the risk of developing HTN, whereas the remaining studies (n = 14) did not show a significant association. Available literature suggests an apparent association between rs1801133 and HTN in global regions; however, such information is still scarce in Africa, especially in the black African population.
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spelling pubmed-90274652022-04-23 Methylenetetrahydrofolate Reductase Polymorphism (rs1801133) and the Risk of Hypertension among African Populations: A Narrative Synthesis of Literature Mabhida, Sihle E. Muhamed, Babu Sharma, Jyoti R. Apalata, Teke Nomatshila, Sibusiso Mabasa, Lawrence Benjeddou, Mongi Masilela, Charity Ziqubu, Khanyisani Shabalala, Samukelisiwe Johnson, Rabia Genes (Basel) Review In this review, we have gathered and analyzed the available genetic evidence on the association between the methylenetetrahydrofolate reductase gene (MTHFR), rs1801133 and the risk of Hypertension (HTN) in African populations, which was further compared to the global data evidence. This review was reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol and Human Genome Epidemiology Network (HuGENet) guidelines. Literature was retrieved through major search databases, including PubMed, Scopus, Web of Science, and African Journal Online. We identified 64 potential studies, of which 4 studies were from the African continent and 60 studies were reported globally. Among the studies conducted in Africa, only two (n = 2) reported a significant association between the MTHFR (rs1801133) and the risk of developing HTN. Only one (n = 1) study population was purely composed of black Africans, while others were of other ethnicities. Among studies conducted in other continents (n = 60), forty-seven (n = 47) studies reported a positive association between MTHFR (rs1801133) and the risk of developing HTN, whereas the remaining studies (n = 14) did not show a significant association. Available literature suggests an apparent association between rs1801133 and HTN in global regions; however, such information is still scarce in Africa, especially in the black African population. MDPI 2022-04-01 /pmc/articles/PMC9027465/ /pubmed/35456437 http://dx.doi.org/10.3390/genes13040631 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mabhida, Sihle E.
Muhamed, Babu
Sharma, Jyoti R.
Apalata, Teke
Nomatshila, Sibusiso
Mabasa, Lawrence
Benjeddou, Mongi
Masilela, Charity
Ziqubu, Khanyisani
Shabalala, Samukelisiwe
Johnson, Rabia
Methylenetetrahydrofolate Reductase Polymorphism (rs1801133) and the Risk of Hypertension among African Populations: A Narrative Synthesis of Literature
title Methylenetetrahydrofolate Reductase Polymorphism (rs1801133) and the Risk of Hypertension among African Populations: A Narrative Synthesis of Literature
title_full Methylenetetrahydrofolate Reductase Polymorphism (rs1801133) and the Risk of Hypertension among African Populations: A Narrative Synthesis of Literature
title_fullStr Methylenetetrahydrofolate Reductase Polymorphism (rs1801133) and the Risk of Hypertension among African Populations: A Narrative Synthesis of Literature
title_full_unstemmed Methylenetetrahydrofolate Reductase Polymorphism (rs1801133) and the Risk of Hypertension among African Populations: A Narrative Synthesis of Literature
title_short Methylenetetrahydrofolate Reductase Polymorphism (rs1801133) and the Risk of Hypertension among African Populations: A Narrative Synthesis of Literature
title_sort methylenetetrahydrofolate reductase polymorphism (rs1801133) and the risk of hypertension among african populations: a narrative synthesis of literature
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027465/
https://www.ncbi.nlm.nih.gov/pubmed/35456437
http://dx.doi.org/10.3390/genes13040631
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