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A Study on Biocompatible Polymer-Based Packaging of Neural Interface for Chronic Implantation
This paper proposed and verified the use of polymer-based packaging to implement the chronic implantation of neural interfaces using a combination of a commercial thermal epoxy and a thin parylene film. The packaging’s characteristics and the performance of the vulnerable interface between the therm...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027597/ https://www.ncbi.nlm.nih.gov/pubmed/35457821 http://dx.doi.org/10.3390/mi13040516 |
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author | Park, HyungDal Choi, Wonsuk Oh, Seonghwan Kim, Yong-Jun Seok, Seonho Kim, Jinseok |
author_facet | Park, HyungDal Choi, Wonsuk Oh, Seonghwan Kim, Yong-Jun Seok, Seonho Kim, Jinseok |
author_sort | Park, HyungDal |
collection | PubMed |
description | This paper proposed and verified the use of polymer-based packaging to implement the chronic implantation of neural interfaces using a combination of a commercial thermal epoxy and a thin parylene film. The packaging’s characteristics and the performance of the vulnerable interface between the thermal epoxy layer and polyimide layer, which is mainly used for neural electrodes and an FPCB, were evaluated through in vitro, in vivo, and acceleration experiments. The performance of neural interfaces—composed of the combination of the thermal epoxy and thin parylene film deposition as encapsulation packaging—was evaluated by using signal acquisition experiments based on artificial stimulation signal transmissions through in vitro and in vivo experiments. It has been found that, when commercial thermal epoxy normally cured at room temperature was cured at higher temperatures of 45 °C and 65 °C, not only is its lifetime increased with about twice the room-temperature-based curing conditions but also an interfacial adhesion is higher with more than twice the room-temperature-based curing conditions. In addition, through in vivo experiments using rats, it was confirmed that bodily fluids did not flow into the interface between the thermal epoxy and FPCB for up to 18 months, and it was verified that the rats maintained healthy conditions without occurring an immune response in the body to the thin parylene film deposition on the packaging’s surface. |
format | Online Article Text |
id | pubmed-9027597 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90275972022-04-23 A Study on Biocompatible Polymer-Based Packaging of Neural Interface for Chronic Implantation Park, HyungDal Choi, Wonsuk Oh, Seonghwan Kim, Yong-Jun Seok, Seonho Kim, Jinseok Micromachines (Basel) Article This paper proposed and verified the use of polymer-based packaging to implement the chronic implantation of neural interfaces using a combination of a commercial thermal epoxy and a thin parylene film. The packaging’s characteristics and the performance of the vulnerable interface between the thermal epoxy layer and polyimide layer, which is mainly used for neural electrodes and an FPCB, were evaluated through in vitro, in vivo, and acceleration experiments. The performance of neural interfaces—composed of the combination of the thermal epoxy and thin parylene film deposition as encapsulation packaging—was evaluated by using signal acquisition experiments based on artificial stimulation signal transmissions through in vitro and in vivo experiments. It has been found that, when commercial thermal epoxy normally cured at room temperature was cured at higher temperatures of 45 °C and 65 °C, not only is its lifetime increased with about twice the room-temperature-based curing conditions but also an interfacial adhesion is higher with more than twice the room-temperature-based curing conditions. In addition, through in vivo experiments using rats, it was confirmed that bodily fluids did not flow into the interface between the thermal epoxy and FPCB for up to 18 months, and it was verified that the rats maintained healthy conditions without occurring an immune response in the body to the thin parylene film deposition on the packaging’s surface. MDPI 2022-03-26 /pmc/articles/PMC9027597/ /pubmed/35457821 http://dx.doi.org/10.3390/mi13040516 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Park, HyungDal Choi, Wonsuk Oh, Seonghwan Kim, Yong-Jun Seok, Seonho Kim, Jinseok A Study on Biocompatible Polymer-Based Packaging of Neural Interface for Chronic Implantation |
title | A Study on Biocompatible Polymer-Based Packaging of Neural Interface for Chronic Implantation |
title_full | A Study on Biocompatible Polymer-Based Packaging of Neural Interface for Chronic Implantation |
title_fullStr | A Study on Biocompatible Polymer-Based Packaging of Neural Interface for Chronic Implantation |
title_full_unstemmed | A Study on Biocompatible Polymer-Based Packaging of Neural Interface for Chronic Implantation |
title_short | A Study on Biocompatible Polymer-Based Packaging of Neural Interface for Chronic Implantation |
title_sort | study on biocompatible polymer-based packaging of neural interface for chronic implantation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027597/ https://www.ncbi.nlm.nih.gov/pubmed/35457821 http://dx.doi.org/10.3390/mi13040516 |
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