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Clinical Role of Serum miR107 in Type 2 Diabetes and Related Risk Factors

Background: As the diagnostic and treatment options for diabetes improve, more attention nowadays is being paid to the exact identification of the etiopathological mechanism of type 2 diabetes (T2DM). Insulin resistance (IR) is a pathogenetic background for T2DM. Several studies demonstrate that miR...

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Autores principales: Šimonienė, Diana, Stukas, Darius, Daukša, Albertas, Veličkienė, Džilda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027608/
https://www.ncbi.nlm.nih.gov/pubmed/35454146
http://dx.doi.org/10.3390/biom12040558
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author Šimonienė, Diana
Stukas, Darius
Daukša, Albertas
Veličkienė, Džilda
author_facet Šimonienė, Diana
Stukas, Darius
Daukša, Albertas
Veličkienė, Džilda
author_sort Šimonienė, Diana
collection PubMed
description Background: As the diagnostic and treatment options for diabetes improve, more attention nowadays is being paid to the exact identification of the etiopathological mechanism of type 2 diabetes (T2DM). Insulin resistance (IR) is a pathogenetic background for T2DM. Several studies demonstrate that miRNAs play an important role in systemic inflammation and thus in T2DM pathogenesis. Overexpression of miR-107 may cause an imbalance of glucose homeostasis, obesity, and dyslipidemia, by regulating insulin sensitivity through the insulin signaling pathway. Methods: 53 patients with T2DM and 54 nondiabetic patients were involved in the study. This study aimed to examine whether miR-107 expression in the serum of patients with diabetes was different from the control group (non-diabetic) and whether miR-107 expression correlated with lipid levels, BMI, and other factors, and finally, with insulin resistance in general. Results: miR-107 expression was higher in the T2DM group than in the control group (1.33 versus 0.63 (p = 0.016). In general, miR-107 expression was directly and positively associated with BMI (r = 0.3, p = 0.01), age (r = 0.3, p = 0.004), and male gender (p = 0.006). Moreover, miR-107 was related to dyslipidemia: Patients with higher miR-107 levels had lower HDL levels (in the control group: r = −0.262, p = 0.022 vs. diabetic group: r = −0.315, p = 0.007). Finally, the overexpression of miR-107 was associated with higher HOMA-IR in the diabetic group (r = 0.373, p = 0.035). Conclusion: MiR-107 expression is higher among diabetic patients than that of nondiabetic control subjects. Higher miR-107 levels are also related to dyslipidemia (lower HDL levels)—in the general cohort and non-diabetic subjects. Moreover, higher miR-107 expression is related to insulin resistance in the diabetic group. In general, higher miR-107 expression levels are related to a higher BMI, older age, and the male gender.
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spelling pubmed-90276082022-04-23 Clinical Role of Serum miR107 in Type 2 Diabetes and Related Risk Factors Šimonienė, Diana Stukas, Darius Daukša, Albertas Veličkienė, Džilda Biomolecules Article Background: As the diagnostic and treatment options for diabetes improve, more attention nowadays is being paid to the exact identification of the etiopathological mechanism of type 2 diabetes (T2DM). Insulin resistance (IR) is a pathogenetic background for T2DM. Several studies demonstrate that miRNAs play an important role in systemic inflammation and thus in T2DM pathogenesis. Overexpression of miR-107 may cause an imbalance of glucose homeostasis, obesity, and dyslipidemia, by regulating insulin sensitivity through the insulin signaling pathway. Methods: 53 patients with T2DM and 54 nondiabetic patients were involved in the study. This study aimed to examine whether miR-107 expression in the serum of patients with diabetes was different from the control group (non-diabetic) and whether miR-107 expression correlated with lipid levels, BMI, and other factors, and finally, with insulin resistance in general. Results: miR-107 expression was higher in the T2DM group than in the control group (1.33 versus 0.63 (p = 0.016). In general, miR-107 expression was directly and positively associated with BMI (r = 0.3, p = 0.01), age (r = 0.3, p = 0.004), and male gender (p = 0.006). Moreover, miR-107 was related to dyslipidemia: Patients with higher miR-107 levels had lower HDL levels (in the control group: r = −0.262, p = 0.022 vs. diabetic group: r = −0.315, p = 0.007). Finally, the overexpression of miR-107 was associated with higher HOMA-IR in the diabetic group (r = 0.373, p = 0.035). Conclusion: MiR-107 expression is higher among diabetic patients than that of nondiabetic control subjects. Higher miR-107 levels are also related to dyslipidemia (lower HDL levels)—in the general cohort and non-diabetic subjects. Moreover, higher miR-107 expression is related to insulin resistance in the diabetic group. In general, higher miR-107 expression levels are related to a higher BMI, older age, and the male gender. MDPI 2022-04-08 /pmc/articles/PMC9027608/ /pubmed/35454146 http://dx.doi.org/10.3390/biom12040558 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Šimonienė, Diana
Stukas, Darius
Daukša, Albertas
Veličkienė, Džilda
Clinical Role of Serum miR107 in Type 2 Diabetes and Related Risk Factors
title Clinical Role of Serum miR107 in Type 2 Diabetes and Related Risk Factors
title_full Clinical Role of Serum miR107 in Type 2 Diabetes and Related Risk Factors
title_fullStr Clinical Role of Serum miR107 in Type 2 Diabetes and Related Risk Factors
title_full_unstemmed Clinical Role of Serum miR107 in Type 2 Diabetes and Related Risk Factors
title_short Clinical Role of Serum miR107 in Type 2 Diabetes and Related Risk Factors
title_sort clinical role of serum mir107 in type 2 diabetes and related risk factors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027608/
https://www.ncbi.nlm.nih.gov/pubmed/35454146
http://dx.doi.org/10.3390/biom12040558
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