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Validation of Intrinsic Left Ventricular Assist Device Data Tracking Algorithm for Early Recognition of Centrifugal Flow Pump Thrombosis

Advanced stage heart failure patients can benefit from the unloading effects of an implantable left ventricular assist device. Despite best clinical practice, LVADs are associated with adverse events, such as pump thrombosis (PT). An adaptive algorithm alerting when an individual’s appropriate level...

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Autores principales: Gross, Christoph, Dimitrov, Kamen, Riebandt, Julia, Wiedemann, Dominik, Laufer, Günther, Schima, Heinrich, Moscato, Francesco, Brown, Michael C., Kadrolkar, Abhijit, Stadler, Robert W., Zimpfer, Daniel, Schlöglhofer, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027619/
https://www.ncbi.nlm.nih.gov/pubmed/35455054
http://dx.doi.org/10.3390/life12040563
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author Gross, Christoph
Dimitrov, Kamen
Riebandt, Julia
Wiedemann, Dominik
Laufer, Günther
Schima, Heinrich
Moscato, Francesco
Brown, Michael C.
Kadrolkar, Abhijit
Stadler, Robert W.
Zimpfer, Daniel
Schlöglhofer, Thomas
author_facet Gross, Christoph
Dimitrov, Kamen
Riebandt, Julia
Wiedemann, Dominik
Laufer, Günther
Schima, Heinrich
Moscato, Francesco
Brown, Michael C.
Kadrolkar, Abhijit
Stadler, Robert W.
Zimpfer, Daniel
Schlöglhofer, Thomas
author_sort Gross, Christoph
collection PubMed
description Advanced stage heart failure patients can benefit from the unloading effects of an implantable left ventricular assist device. Despite best clinical practice, LVADs are associated with adverse events, such as pump thrombosis (PT). An adaptive algorithm alerting when an individual’s appropriate levels in pump power uptake are exceeded, such as in the case of PT, can improve therapy of patients implanted with a centrifugal LVAD. We retrospectively studied 75 patients implanted with a centrifugal LVAD in a single center. A previously optimized adaptive pump power-tracking algorithm was compared to clinical best practice and clinically available constant threshold algorithms. Algorithm performances were analyzed in a PT group (n = 16 patients with 30 PT events) and a thoroughly selected control group (n = 59 patients, 34.7 patient years of LVAD data). Comparison of the adaptive power-tracking algorithm with the best performing constant threshold algorithm resulted in sensitivity of 83.3% vs. 86.7% and specificity of 98.9% vs. 95.3%, respectively. The power-tracking algorithm produced one false positive detection every 11.6 patient years and early warnings with a median of 3.6 days prior to PT diagnosis. In conclusion, a retrospective single-center validation study with real-world patient data demonstrated advantageous application of a power-tracking algorithm into LVAD systems and clinical practice.
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spelling pubmed-90276192022-04-23 Validation of Intrinsic Left Ventricular Assist Device Data Tracking Algorithm for Early Recognition of Centrifugal Flow Pump Thrombosis Gross, Christoph Dimitrov, Kamen Riebandt, Julia Wiedemann, Dominik Laufer, Günther Schima, Heinrich Moscato, Francesco Brown, Michael C. Kadrolkar, Abhijit Stadler, Robert W. Zimpfer, Daniel Schlöglhofer, Thomas Life (Basel) Article Advanced stage heart failure patients can benefit from the unloading effects of an implantable left ventricular assist device. Despite best clinical practice, LVADs are associated with adverse events, such as pump thrombosis (PT). An adaptive algorithm alerting when an individual’s appropriate levels in pump power uptake are exceeded, such as in the case of PT, can improve therapy of patients implanted with a centrifugal LVAD. We retrospectively studied 75 patients implanted with a centrifugal LVAD in a single center. A previously optimized adaptive pump power-tracking algorithm was compared to clinical best practice and clinically available constant threshold algorithms. Algorithm performances were analyzed in a PT group (n = 16 patients with 30 PT events) and a thoroughly selected control group (n = 59 patients, 34.7 patient years of LVAD data). Comparison of the adaptive power-tracking algorithm with the best performing constant threshold algorithm resulted in sensitivity of 83.3% vs. 86.7% and specificity of 98.9% vs. 95.3%, respectively. The power-tracking algorithm produced one false positive detection every 11.6 patient years and early warnings with a median of 3.6 days prior to PT diagnosis. In conclusion, a retrospective single-center validation study with real-world patient data demonstrated advantageous application of a power-tracking algorithm into LVAD systems and clinical practice. MDPI 2022-04-09 /pmc/articles/PMC9027619/ /pubmed/35455054 http://dx.doi.org/10.3390/life12040563 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gross, Christoph
Dimitrov, Kamen
Riebandt, Julia
Wiedemann, Dominik
Laufer, Günther
Schima, Heinrich
Moscato, Francesco
Brown, Michael C.
Kadrolkar, Abhijit
Stadler, Robert W.
Zimpfer, Daniel
Schlöglhofer, Thomas
Validation of Intrinsic Left Ventricular Assist Device Data Tracking Algorithm for Early Recognition of Centrifugal Flow Pump Thrombosis
title Validation of Intrinsic Left Ventricular Assist Device Data Tracking Algorithm for Early Recognition of Centrifugal Flow Pump Thrombosis
title_full Validation of Intrinsic Left Ventricular Assist Device Data Tracking Algorithm for Early Recognition of Centrifugal Flow Pump Thrombosis
title_fullStr Validation of Intrinsic Left Ventricular Assist Device Data Tracking Algorithm for Early Recognition of Centrifugal Flow Pump Thrombosis
title_full_unstemmed Validation of Intrinsic Left Ventricular Assist Device Data Tracking Algorithm for Early Recognition of Centrifugal Flow Pump Thrombosis
title_short Validation of Intrinsic Left Ventricular Assist Device Data Tracking Algorithm for Early Recognition of Centrifugal Flow Pump Thrombosis
title_sort validation of intrinsic left ventricular assist device data tracking algorithm for early recognition of centrifugal flow pump thrombosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027619/
https://www.ncbi.nlm.nih.gov/pubmed/35455054
http://dx.doi.org/10.3390/life12040563
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