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What Are the Potential Benefits of Using Bacteriophages in Periodontal Therapy?

Periodontitis, which may result in tooth loss, constitutes both a serious medical and social problem. This pathology, if not treated, can contribute to the development of, among others, pancreatic cancer, cardiovascular diseases or Alzheimer’s disease. The available treatment methods are expensive b...

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Autores principales: Kowalski, Jan, Górska, Renata, Cieślik, Martyna, Górski, Andrzej, Jończyk-Matysiak, Ewa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027636/
https://www.ncbi.nlm.nih.gov/pubmed/35453197
http://dx.doi.org/10.3390/antibiotics11040446
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author Kowalski, Jan
Górska, Renata
Cieślik, Martyna
Górski, Andrzej
Jończyk-Matysiak, Ewa
author_facet Kowalski, Jan
Górska, Renata
Cieślik, Martyna
Górski, Andrzej
Jończyk-Matysiak, Ewa
author_sort Kowalski, Jan
collection PubMed
description Periodontitis, which may result in tooth loss, constitutes both a serious medical and social problem. This pathology, if not treated, can contribute to the development of, among others, pancreatic cancer, cardiovascular diseases or Alzheimer’s disease. The available treatment methods are expensive but not always fully effective. For this reason, the search for and isolation of bacteriophages specific to bacterial strains causing periodontitis seems to be a great opportunity to target persistent colonization by bacterial pathogens and lower the use of antibiotics consequently limiting further development of antibiotic resistance. Furthermore, antimicrobial resistance (AMR) constitutes a growing challenge in periodontal therapy as resistant pathogens may be isolated from more than 70% of patients with periodontitis. The aim of this review is to present the perspective of phage application in the prevention and/or treatment of periodontitis alongside its complicated multifactorial aetiology and emphasize the challenges connecting composition and application of effective phage preparation.
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spelling pubmed-90276362022-04-23 What Are the Potential Benefits of Using Bacteriophages in Periodontal Therapy? Kowalski, Jan Górska, Renata Cieślik, Martyna Górski, Andrzej Jończyk-Matysiak, Ewa Antibiotics (Basel) Review Periodontitis, which may result in tooth loss, constitutes both a serious medical and social problem. This pathology, if not treated, can contribute to the development of, among others, pancreatic cancer, cardiovascular diseases or Alzheimer’s disease. The available treatment methods are expensive but not always fully effective. For this reason, the search for and isolation of bacteriophages specific to bacterial strains causing periodontitis seems to be a great opportunity to target persistent colonization by bacterial pathogens and lower the use of antibiotics consequently limiting further development of antibiotic resistance. Furthermore, antimicrobial resistance (AMR) constitutes a growing challenge in periodontal therapy as resistant pathogens may be isolated from more than 70% of patients with periodontitis. The aim of this review is to present the perspective of phage application in the prevention and/or treatment of periodontitis alongside its complicated multifactorial aetiology and emphasize the challenges connecting composition and application of effective phage preparation. MDPI 2022-03-25 /pmc/articles/PMC9027636/ /pubmed/35453197 http://dx.doi.org/10.3390/antibiotics11040446 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kowalski, Jan
Górska, Renata
Cieślik, Martyna
Górski, Andrzej
Jończyk-Matysiak, Ewa
What Are the Potential Benefits of Using Bacteriophages in Periodontal Therapy?
title What Are the Potential Benefits of Using Bacteriophages in Periodontal Therapy?
title_full What Are the Potential Benefits of Using Bacteriophages in Periodontal Therapy?
title_fullStr What Are the Potential Benefits of Using Bacteriophages in Periodontal Therapy?
title_full_unstemmed What Are the Potential Benefits of Using Bacteriophages in Periodontal Therapy?
title_short What Are the Potential Benefits of Using Bacteriophages in Periodontal Therapy?
title_sort what are the potential benefits of using bacteriophages in periodontal therapy?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027636/
https://www.ncbi.nlm.nih.gov/pubmed/35453197
http://dx.doi.org/10.3390/antibiotics11040446
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